Toward Proton Computed Tomography

Sadrozinski, H. F-W.; Bashkirov, V.; Keeney, Brian A.; Johnson, Leah R.; Peggs, S.; Ross, Graham G.; Satogata, T.; Schulte, R.; Seiden, A.; Shanazi, K.; Williams, D.C.

doi:10.1109/tns.2003.823044

Cited by 44 publications

(14 citation statements)

References 21 publications

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“…the position of the small volume where most of energy is deposited in the body, strongly depends on the energy of the particle and on the density of the traversed tissues. As the particle energy can be controlled with a precision better than 0.5 % (2) , the precise knowledge of the tissue density along the particle path becomes the limiting factor in precisely aiming at the tumour cells and is hence critical for effectively exploiting the intrinsic hadron energy deposition resolution. Such knowledge is nowadays gathered by using standard X-ray computed tomography (X-ray CT), to generate a 3D image of the body target.…”

Section: Introductionmentioning

confidence: 99%

“…Among the many solutions proposed to overcome this limitation, the most promising one uses protons also for the 3D imaging of the target, actually realising a proton computed tomography, pCT (2,5) . By tracking protons of high energy (at least 200 MeV, so they do not stop inside the body), it is possible to generate a 3D view of the target, exactly as in an X-ray CT, by moving the proton source around the target (or by rotating the target itself ) and recording at each step the paths and energy loss of the particle.…”

Section: Introductionmentioning

confidence: 99%

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Advanced proton imaging in computed tomography

Mattiazzo

Bisello

Giubilato

et al. 2015

Radiat Prot Dosimetry

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In recent years the use of hadrons for cancer radiation treatment has grown in importance, and many facilities are currently operational or under construction worldwide. To fully exploit the therapeutic advantages offered by hadron therapy, precise body imaging for accurate beam delivery is decisive. Proton computed tomography ( pCT) scanners, currently in their R&D phase, provide the ultimate 3D imaging for hadrons treatment guidance. A key component of a pCT scanner is the detector used to track the protons, which has great impact on the scanner performances and ultimately limits its maximum speed. In this article, a novel proton-tracking detector was presented that would have higher scanning speed, better spatial resolution and lower material budget with respect to present state-of-the-art detectors, leading to enhanced performances. This advancement in performances is achieved by employing the very latest development in monolithic active pixel detectors (to build high granularity, low material budget, large area silicon detectors) and a completely new proprietary architecture (to effectively compress the data).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Advanced proton imaging in computed tomography

Mattiazzo

Bisello

Giubilato

et al. 2015

Radiat Prot Dosimetry

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“…by measuring the residual range of protons of higher energy than those stopping in the patient. We presented the requirements for pCT in 2002 [1], and proposed in 2003 a detector system [2], which incorporated the basic building blocks of a pCT system: a tracker to measure the proton path before and after the phantom, and allows to calculate the Most Likely Path (MLP) the proton has taken within the phantom [3], and an energy detector to measure the residual energy or range of the proton, which is used to calculate the Water Equivalent Path Length (WEPL) in the phantom.…”

Section: Introductionmentioning

confidence: 99%

Development of a head scanner for proton CT

Sadrozinski

Johnson

Macafee

et al. 2013

Nuclear Instruments and Methods in Physics Research Section A:

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We describe a new head scanner developed for Proton Computed Tomography (pCT) in support of proton therapy treatment planning, aiming at reconstructing an accurate map of the stopping power (S.P.) in a phantom and, in the future, in patients. The system consists of two silicon telescopes which track the proton before and after the phantom/patient, and an energy detector which measures the residual energy or range of the proton to reconstruct the Water Equivalent Path Length (WEPL) in the phantom. Based on the experience of the existing prototype and extensive Geant4 simulations and CT reconstructions, the new pCT scanner will support clinically useful proton fluxes.

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“…However the use of xCT images for proton treatment planning ignores the fundamental differences in physical process between proton and photons and is, therefore, potentially inaccurate [5].…”

Section: Introductionmentioning

confidence: 99%

Monte Carlo and Analytical Calculation of Lateral Deflection of Proton Beams in Homogeneous Targets

Pazianotto¹,

Inocente²,

Silva³

et al. 2010

AIP Conference Proceedings

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Abstract. Proton radiation therapy is a precise form of radiation therapy, but the avoidance of damage to critical normal tissues and the prevention of geographical tumor misses require accurate knowledge of the dose delivered to the patient and the verification of his position demand a precise imaging technique. In proton therapy facilities, the X-ray Computed Tomography (xCT) is the preferred technique for the planning treatment of patients. This situation has been changing nowadays with the development of proton accelerators for health care and the increase in the number of treated patients. In fact, protons could be more efficient than xCT for this task. One essential difficulty in pCT image reconstruction systems came from the scattering of the protons inside the target due to the numerous small-angle deflections by nuclear Coulomb fields. The purpose of this study is the comparison of an analytical formulation for the determination of beam lateral deflection, based on Molière's theory and Rutherford scattering with Monte Carlo calculations by SRIM 2008 and MCNPX codes.

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Toward Proton Computed Tomography

Cited by 44 publications

References 21 publications

Advanced proton imaging in computed tomography

Advanced proton imaging in computed tomography

Development of a head scanner for proton CT

Monte Carlo and Analytical Calculation of Lateral Deflection of Proton Beams in Homogeneous Targets

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