Toward regeneration of articular cartilage

Iwamoto, Masahiro; Ohta, Yoshiji; Larmour, Colleen; Enomoto‐Iwamoto, Motomi

doi:10.1002/bdrc.21042

Cited by 78 publications

(59 citation statements)

References 109 publications

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“…Interactions between the extracellular matrix and mature chondrocytes increase with chondrogenesis progression. In fact, cell-to-cell interactions by adhesion molecules such as N-cadherin and N-CAM are involved in cellular condensation and subsequent chondrogenesis (18,19). The extracellular matrix is also involved in the regulation of chondrogenesis through binding, storage and release of soluble factors.…”

Section: The Extracellular Matrix: More Than a Simple Protein Bulkmentioning

confidence: 99%

Impact of Therapeutic Irradiation on Healthy Articular Cartilage

Saintigny¹,

Cruet-Hennequart²,

Hamdi³

et al. 2015

Radiation Research

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Radiation-induced complications in bone and cartilage are of increasing concern due to potential long-term effects in cancer survivors. Healthy articular cartilage may be exposed to radiation during either chondrosarcoma treatment or in-field radiotherapy of tumors located in close proximity to articulation. Cartilage exposed to radiation undergoes bone differentiation and senescence, which can lead to painful and disabling sequelae that can impair patient quality of life. An understanding of the biological processes involved in healthy cartilage response to radiotherapy may not only optimize the delivery of therapeutic radiation but also reduce the risk of long-term sequelae in irradiated cartilage. Over the last few decades, radiobiology studies have focused primarily on signaling and repair of DNA damage pathways induced by ionizing radiation in immortalized cells under conditions dramatically different from human homeostasis. This research needs to be continued and broadened, since the range of normal tissue responses to radiation exposure is still not fully understood, despite being recognized as the major limiting factor in the rupture of tissue homeostasis after radiotherapy. Human articular cartilage is an avascular tissue with low intracellular oxygen levels and is comprised of a single cell lineage of chondrocytes embedded in a highly dense and structured extracellular matrix. These relatively unique features may impact inherent cell radiation sensitivity and suggests that canonical cell responses to ionizing radiation may not be applicable to articular cartilage. Despite the number of studies in this field, radiation-induced modifications of chondrocyte proteome remain unclear because of the dramatic variability in reported experimental conditions. In this review, we propose to introduce cartilage tissue physiology and microenvironment concepts, and then present a comprehensive synthesis of cartilage radiation biology.

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Section: The Extracellular Matrix: More Than a Simple Protein Bulkmentioning

confidence: 99%

Impact of Therapeutic Irradiation on Healthy Articular Cartilage

Saintigny¹,

Cruet-Hennequart²,

Hamdi³

et al. 2015

Radiation Research

View full text Add to dashboard Cite

show abstract

“…), which possess a net negative charge attracting counteracting cations and high quantities of osmotically obliged water (approx. 70% of the net weight of ECM) [1]. Small leucine-rich proteoglycans (SLRPs) such as decorin, biglycan, and fibromodulin are specialised ECM molecules that contain multiple repeats of a leucine-rich structural motif, flanked by cysteine residues.…”

Section: Introductionmentioning

confidence: 99%

Voltage-Dependent Calcium Channels in Chondrocytes: Roles in Health and Disease

2015

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Chondrocytes, the single cell type in adult articular cartilage, have conventionally been considered to be non-excitable cells. However, recent evidence suggests that their resting membrane potential (RMP) is less negative than that of excitable cells, and they are fully equipped with channels that control ion, water, and osmolyte movement across the chondrocyte membrane. Among calcium-specific ion channels, members of the voltage-dependent calcium channel (VDCC) family are expressed in chondrocytes where they are functionally active. Ltype VDCC inhibitors such as nifedipine and verapamil have contributed to our understanding of the roles of these ion channels in chondrogenesis, chondrocyte signalling, and mechanotransduction. In this narrative review, we discuss published data indicating that VDCC function is vital for chondrocyte health, especially in regulating proliferation and maturation.We also highlight the fact that activation of VDCC function appears to accompany various inflammatory aspects of osteoarthritis (OA) and, based on in vitro data, the application of nifedipine and/or verapamil may be a promising approach for ameliorating OA severity.However, very few studies on clinical outcomes are available regarding the influence of calcium antagonists, which are used primarily for treating cardiovascular conditions in OA patients. This review is intended to stimulate further research on the chondrocyte 'channelome', contribute to the development of novel therapeutic strategies, and facilitate the retargeting and repositioning of existing pharmacological agents currently used for other comorbidities for the treatment of OA.

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“…Further, there is an utmost need to have new reagents that could activate recruiting of intrinsic and extrinsic factors to induce or inject or implant progenitor cells into the damaged sites for repairing [184]. Individual tailored stem cells can be used for therapeutic purposes will be new innovative areas of future research [185,186]. Thus, by using or recruitment of intrinsic stem/progenitor cells in to the damaged site suppression of regeneration activity can be improved and organs could make functional.…”

Section: Future Clinical Prospectsmentioning

confidence: 99%

Stem Cell Therapeutics of Acute Liver Diseases, Transplantation, and Regeneration

Upadhyay¹

2017

J Cell Sci Ther

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Present review article explains various causes of acute liver diseases and their therapeutics. This article describes major reasons of hepatic pathophysiological conditions and diseases including hepatitis, cholestasis, alcoholic and non-alcoholic steatohepatitis, jaundice, liver cirrhosis, carcinogenesis and many others. This article emphasizes use of proliferating hepatocytes, hepatic oval cells, adult human liver mesenchymal stem/progenitor cells, induced pluripotent stem cells (iPSCs) and hematopoietic stem cells in cell transplantation for restoration of liver structure and function. It also justified the therapeutic role of cell secreted growth factors and dietary factors required during natural healing and regeneration liver after surgery or liver transplantation. It sketches out regulatory roles of signaling pathways, expression of cell cycle regulators, growth factors, cytokines, and role of different mitogens in induction of liver stem/progenitor cells (LSPCs) after organ/stem cell transplantation. This article suggests a need for development of new advanced biomaterials, methods, technologies and stem cells for development of targeted therapies to combat and cure liver related diseases and disorders. This article also advice people for avoiding excessive use of alcohol, drugs, fats, salt, high energy diets, and iron as all are responsible of liver cirrhosis, damage and failure.

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Toward regeneration of articular cartilage

Cited by 78 publications

References 109 publications

Impact of Therapeutic Irradiation on Healthy Articular Cartilage

Impact of Therapeutic Irradiation on Healthy Articular Cartilage

Voltage-Dependent Calcium Channels in Chondrocytes: Roles in Health and Disease

Stem Cell Therapeutics of Acute Liver Diseases, Transplantation, and Regeneration

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