Toward the development of defined microbial therapeutics

Li, Youxian; Honda, Kenya

doi:10.1093/intimm/dxab038

Cited by 9 publications

(4 citation statements)

References 56 publications

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“…The choice of strains included in the mixture is based on replenishing the bacteria absent in the patient. In addition to safety, they are easier to manufacture and more consistent between batches [ 207 , 208 ].…”

Section: Safety Of An Fmt Alternatives and Future Perspectivesmentioning

confidence: 99%

Any Future for Faecal Microbiota Transplantation as a Novel Strategy for Gut Microbiota Modulation in Human and Veterinary Medicine?

Takáčová

Bomba²,

Tóthová

et al. 2022

Life

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Alterations in the composition of the intestinal microbiome, also known as dysbiosis, are the result of many factors such as diet, antibiotics, stress, diseases, etc. There are currently several ways to modulate intestinal microbiome such as dietary modulation, the use of antimicrobials, prebiotics, probiotics, postbiotics, and synbiotics. Faecal microbiota transplantation (FMT) represents one new method of gut microbiota modulation in humans with the aim of reconstructing the intestinal microbiome of the recipient. In human medicine, this form of bacteriotherapy is successfully used in cases of recurrent Clostridium difficile infection (CDI). FMT has been known in large animal medicine for several years. In small animal medicine, the use of FMT is not part of normal practice.

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Section: Safety Of An Fmt Alternatives and Future Perspectivesmentioning

confidence: 99%

Any Future for Faecal Microbiota Transplantation as a Novel Strategy for Gut Microbiota Modulation in Human and Veterinary Medicine?

Takáčová

Bomba²,

Tóthová

et al. 2022

Life

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“…Bacterial consortia and certain stool-derived microbial products that contain fewer taxa of bacteria, viruses, and fungi also seem to be promising approaches [ 203 ]. Although no such product is yet in the market, a number of them are in development phases.…”

Section: Discussionmentioning

confidence: 99%

Interplay of Gut Microbiota in Polycystic Ovarian Syndrome: Role of Gut Microbiota, Mechanistic Pathways and Potential Treatment Strategies

et al. 2023

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Polycystic Ovarian Syndrome (PCOS) comprises a set of symptoms that pose significant risk factors for various diseases, including type 2 diabetes, cardiovascular disease, and cancer. Effective and safe methods to treat all the pathological symptoms of PCOS are not available. The gut microbiota has been shown to play an essential role in PCOS incidence and progression. Many dietary plants, prebiotics, and probiotics have been reported to ameliorate PCOS. Gut microbiota shows its effects in PCOS via a number of mechanistic pathways including maintenance of homeostasis, regulation of lipid and blood glucose levels. The effect of gut microbiota on PCOS has been widely reported in animal models but there are only a few reports of human studies. Increasing the diversity of gut microbiota, and up-regulating PCOS ameliorating gut microbiota are some of the ways through which prebiotics, probiotics, and polyphenols work. We present a comprehensive review on polyphenols from natural origin, probiotics, and fecal microbiota therapy that may be used to treat PCOS by modifying the gut microbiota.

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“…Performing FMT is not without risk, and harmful microorganisms have been transferred via FMT to recipients ( 169 , 170 ). Therefore, it may be safer to use a defined microbial consortium, which also has the potential to elicit an effective and durable clinical response due to optimized symbiosis between the microbes ( 171 ). However, further studies are needed to determine if colonization of such a defined consortium could be a treatment option in metabolic disease.…”

Section: Therapeutic Potential Of the Microbiomementioning

confidence: 99%

The Metabolic Role and Therapeutic Potential of the Microbiome

Olofsson

Bäckhed

2022

Endocrine Reviews

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We are host to an assembly of microorganisms that vary in structure and function along the length of the gut and from the lumen to the mucosa. This ecosystem is collectively known as the gut microbiota and significant efforts have been spent during the past two decades to catalog and functionally describe the normal gut microbiota and how it varies during a wide spectrum of disease states. The gut microbiota is altered in several cardiometabolic diseases and recent work has established microbial signatures that may proceed disease. However, most research has focused on identifying associations between the gut microbiota and human diseases states and to investigate causality and potential mechanisms using cells and animals. Since the gut microbiota functions on the intersection between diet and host metabolism, and can contribute to inflammation, several microbially produced metabolites and molecules may modulate cardiometabolic diseases. Here we discuss how the gut bacterial composition is altered in, and can contribute to, cardiometabolic disease, as well as how the gut bacteria can be targeted to treat and prevent metabolic diseases.

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Toward the development of defined microbial therapeutics

Cited by 9 publications

References 56 publications

Any Future for Faecal Microbiota Transplantation as a Novel Strategy for Gut Microbiota Modulation in Human and Veterinary Medicine?

Any Future for Faecal Microbiota Transplantation as a Novel Strategy for Gut Microbiota Modulation in Human and Veterinary Medicine?

Interplay of Gut Microbiota in Polycystic Ovarian Syndrome: Role of Gut Microbiota, Mechanistic Pathways and Potential Treatment Strategies

The Metabolic Role and Therapeutic Potential of the Microbiome

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