Toward Ultrasensitive Surface Plasmon Resonance Sensors

Scherbahn, Vitali; Nizamov, Shavkat; Mirsky, Vladimir M.

doi:10.1007/5346_2017_21

Cited by 7 publications

(5 citation statements)

References 138 publications

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“…Past 30 minutes etching, inter-crystalline boundaries begins to appear simultaneously to change in texture, self-consistent with processes starting to take place on the surface of individual crystallites until the film is completely etched. The proposed protocol may help better reproducibility and stimulate further application of noble films in (bio)sensors, particularly architectures combining nanostructured functional subunits spatially arranged in a specific manner [112][113][114][115]. The results also indicate that native polycrystalline gold films are not suitable for direct applications in biosensors, even after chemical polishing.…”

Section: Discussionmentioning

confidence: 99%

Gold surface cleaning by etching polishing: Optimization of polycrystalline film topography and surface functionality for biosensing

Snopok

Laroussi

Cafolla

et al. 2021

Surfaces and Interfaces

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Section: Discussionmentioning

confidence: 99%

Gold surface cleaning by etching polishing: Optimization of polycrystalline film topography and surface functionality for biosensing

Snopok

Laroussi

Cafolla

et al. 2021

Surfaces and Interfaces

Self Cite

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“…At status year 2018, the companies offering SPR instrumentation are named with the designation of sold instruments. Discussion of ultrasensitive SPR [177,178] is another new topic. An interesting aspect in the monitoring of cell-based assays is the combination of impedance analysis and SPR.…”

Section: Fibers and Waveguides Without Structurementioning

confidence: 99%

Critical assessment of relevant methods in the field of biosensors with direct optical detection based on fibers and waveguides using plasmonic, resonance, and interference effects

Gauglitz

2020

Anal Bioanal Chem

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Direct optical detection has proven to be a highly interesting tool in biomolecular interaction analysis to be used in drug discovery, ligand/receptor interactions, environmental analysis, clinical diagnostics, screening of large data volumes in immunology, cancer therapy, or personalized medicine. In this review, the fundamental optical principles and applications are reviewed. Devices are based on concepts such as refractometry, evanescent field, waveguides modes, reflectometry, resonance and/or interference. They are realized in ring resonators; prism couplers; surface plasmon resonance; resonant mirror; Bragg grating; grating couplers; photonic crystals, Mach-Zehnder, Young, Hartman interferometers; backscattering; ellipsometry; or reflectance interferometry. The physical theories of various optical principles have already been reviewed in detail elsewhere and are therefore only cited. This review provides an overall survey on the application of these methods in direct optical biosensing. The "historical" development of the main principles is given to understand the various, and sometimes only slightly modified variations published as "new" methods or the use of a new acronym and commercialization by different companies. Improvement of optics is only one way to increase the quality of biosensors. Additional essential aspects are the surface modification of transducers, immobilization strategies, selection of recognition elements, the influence of non-specific interaction, selectivity, and sensitivity. Furthermore, papers use for reporting minimal amounts of detectable analyte terms such as value of mass, moles, grams, or mol/L which are difficult to compare. Both these essential aspects (i.e., biochemistry and the presentation of LOD values) can be discussed only in brief (but references are provided) in order to prevent the paper from becoming too long. The review will concentrate on a comparison of the optical methods, their application, and the resulting bioanalytical quality.

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“…This can be seen nicely by comparing the response in pg/mm 2 in Figures 2a and 3a for the same refractive index discontinuities. (As a side remark, a multitude of approaches have been developed to discriminate between the bulk refractive index changes and surface effects, for instance, by a penetration depth difference of two surface plasmon modes [57][58][59]. In essence, this is just a clever way to artificially reduce the penetration depth by postprocessing.…”

Section: Sensitivity Of Unreferenced Refractometric Biosensors To Covmentioning

confidence: 99%

Ultra Stable Molecular Sensors by Submicron Referencing and Why They Should Be Interrogated by Optical Diffraction—Part II. Experimental Demonstration

Frutiger

Gatterdam

Blickenstorfer

et al. 2020

Sensors

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Label-free optical biosensors are an invaluable tool for molecular interaction analysis. Over the past 30 years, refractometric biosensors and, in particular, surface plasmon resonance have matured to the de facto standard of this field despite a significant cross reactivity to environmental and experimental noise sources. In this paper, we demonstrate that sensors that apply the spatial affinity lock-in principle (part I) and perform readout by diffraction overcome the drawbacks of established refractometric biosensors. We show this with a direct comparison of the cover refractive index jump sensitivity as well as the surface mass resolution of an unstabilized diffractometric biosensor with a state-of-the-art Biacore 8k. A combined refractometric diffractometric biosensor demonstrates that a refractometric sensor requires a much higher measurement precision than the diffractometric to achieve the same resolution. In a conceptual and quantitative discussion, we elucidate the physical reasons behind and define the figure of merit of diffractometric biosensors. Because low-precision unstabilized diffractometric devices achieve the same resolution as bulky stabilized refractometric sensors, we believe that label-free optical sensors might soon move beyond the drug discovery lab as miniaturized, mass-produced environmental/medical sensors. In fact, combined with the right surface chemistry and recognition element, they might even bring the senses of smell/taste to our smart devices.

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Toward Ultrasensitive Surface Plasmon Resonance Sensors

Cited by 7 publications

References 138 publications

Gold surface cleaning by etching polishing: Optimization of polycrystalline film topography and surface functionality for biosensing

Gold surface cleaning by etching polishing: Optimization of polycrystalline film topography and surface functionality for biosensing

Critical assessment of relevant methods in the field of biosensors with direct optical detection based on fibers and waveguides using plasmonic, resonance, and interference effects

Ultra Stable Molecular Sensors by Submicron Referencing and Why They Should Be Interrogated by Optical Diffraction—Part II. Experimental Demonstration

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