Toward Understanding Success and Failures in the Use of Selenium for Cancer Prevention

Steinbrenner, Holger; Speckmann, Bodo; Sies, Helmut

doi:10.1089/ars.2013.5246

Cited by 71 publications

(57 citation statements)

References 92 publications

(132 reference statements)

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“…This is particularly relevant to better understand the role of Se in the prevention and progression of certain diseases (e.g., prostate cancer and type 2 diabetes), which has become unclear after publication of diverging results from large-scale Se intervention trials. 18,[84][85][86] Another research priority is to gain more insight into the inhibition of DNMT and HDAC enzymes by Se, to identify the active Se species, their possible DNMT/HDAC isoform specificity, mechanism of inhibition and the required doses for inhibition in vitro and in vivo. Se-responsive signaling pathways that influence nuclear proteins linked to epigenetic mechanisms, e.g., through nucleosomal remodeling, transcription or DNA repair, as exemplified for GADD45A, also need to be examined closer.…”

Section: Discussionmentioning

confidence: 99%

“…36 VHL is frequently downregulated and mutated in renal cell carcinomas and also found to be deregulated during colorectal carcinogenesis, 37 wherein Se has been attributed protective functions based on epidemiological and animal studies. 18,38 A study with humans assessed the methylation status of colorectal cancer-related genes in healthy rectal mucosa specimens (84 males, 101 females) in relation to Se status. 39 An association was found for WIF1 (wnt inhibitory factor 1) methylation and plasma Se concentration.…”

Section: Influence Of Selenium On Epigenetic Modifications Of Dna Andmentioning

confidence: 99%

“…Moreover, humans with genetically impaired selenoprotein biosynthesis suffer from a severe multisystem disorder. 17 Biological outcomes of murine and human Se supplementation studies (e.g., disease incidences, effects on the transcriptome, epigenome, and on Se status, 18,19 (and references therein) are known to be affected not only by Se dosage, but also by its chemical form and the pre-supplemental Se status. We will therefore briefly present an overview of Se requirements and the metabolism of dietary Se compounds.…”

Section: Introductionmentioning

confidence: 99%

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Epigenetic effects of selenium and their implications for health

2015

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Section: Discussionmentioning

confidence: 99%

Section: Influence Of Selenium On Epigenetic Modifications Of Dna Andmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Epigenetic effects of selenium and their implications for health

2015

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“…It has chemopreventive, anti-inflammatory, antiviral properties and is related in enhancing immunity (Rayman, 2012;Steinbrenner et al, 2013). The health-related properties of Se include but are not limited to protection against cancer, proper function of thyroid gland, and protection against cardiovascular and muscle disorders (Mao and Teng, 2013;Rocourt and Cheng, 2013).…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis of selenium accumulation and expression of antioxidant enzymes in chicken tissues

Zoidis

Demiris

Kominakis

et al. 2014

Animal

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A meta-analysis integrating results of 40 selenium (Se) supplementation experiments that originated from 35 different controlled randomized trials was carried out in an attempt to identify significant factors that affect tissue Se accumulation in chicken. Examined factors included: Se source (12 different sources examined), type of chicken (laying hens or broilers), age of birds at the beginning of supplementation, duration of supplementation, year during which the study was conducted, sex of birds, number of chickens per treatment, method of analysis, tissue type, concentration of Se determined and Se added to feed. A correlation analysis was also carried out between tissue Se concentration and glutathione peroxidase activity. Data analysis showed that the factors significantly affecting tissue Se concentration include type of chicken ( P = 0.006), type of tissue ( P < 0.001) and the analytical method used ( P = 0.014). Although Se source was not found to affect tissue Se concentration (overall P > 0.05), certain inorganic (sodium selenite), calcium selenite, sodium selenate and organic sources (B-Traxim Se), Se-yeast, Se-malt, Se-enriched cabbage and Se-enriched garlic as well as background Se level from feed ingredients were found to significantly affect tissue Se concentration. The Se accumulation rate (estimated as linear regression coefficient of Se concentrations to Se added to feed) discriminated between the various tissues with highest values estimated in the leg muscle and lowest in blood plasma. Correlation analysis has also shown that tissue Se concentration (pooled data) was correlated to Se added to feed (r = 0.529, P < 0.01, log values) and to glutathione peroxidase activity (r = 0.332, P = 0.0478), with the latter not being correlated with Se added to feed. Although significant factors affecting Se concentration were reported in the present study, they do not necessarily indicate the in vivo function of the antioxidant system or the level of accumulated Se as other factors, not examined in the present study, may interact at the level of trace element absorption, distribution and retention.

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“…Three articles in this Forum (Bode and Dong, Kim et al, Wilking et al) have discussed several important well-known as well as some emerging potential targets based on redox signaling and interactions (1,3,8). The other five articles (Khan et al, Li et al, Park and Pezzuto, Steinbrenner et al, Yum et al) have discussed known and emerging antioxidants that may be useful in the prevention as well as treatment of cancer (2,4,5,7,9).In the first original research communications article on pages 89-101 of this Forum (3), Kim and colleagues investigated a new interacting protein partner of NFE2-related factor 2 (Nrf2), which is a transcription factor that controls and integrates stress signals in mammalian cells and responds by modulating a variety of transcriptional programs. Employing the one-strep tag pull-down and LTQ Orbitrap liquid chromatographytandem mass spectrometry, Kim et al identified IQ motif containing GTPase activating protein 1 (IQGAP1) as a new Nrf2 interacting partner.…”

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confidence: 99%

Antioxidants Meet Molecular Targets for Cancer Prevention and Therapeutics

Ahmad

Mukhtar

2013

Antioxidants & Redox Signaling

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A fine balance between oxidants and antioxidants is required for the normal functioning of living systems. A deregulation of this balance has been implicated in many adverse effects and diseases, including cancer. Extensive research has been done in the area of cancer prevention and therapeutics by a wide range of antioxidants, especially naturally occurring and diet-based agents. However, additional efforts are still needed toward clinical development of the most promising antioxidant agents. For this purpose, it is important to focus our efforts toward (i) defining/validating new targets; (ii) identifying novel agents followed by assessments of their efficacy, safety/toxicity, metabolism, and bioavailability in appropriate model systems; and (iii) conducting clinical trials in an appropriate population. Although research with specific antioxidants is important, an emerging critical issue that is up for a debate is whether the ''whole foods'' concept is better for cancer prevention than a single agent. Recent work has suggested that the dietary phytochemicals can enhance the bioavailability of different nutrients and can target multiple molecular pathways to yield a better response. Another critical issue that is often ignored during target-based agent development is a lack of focus on the appropriate population for a specific target. It is possible that a specific target may not be appropriate for certain people. Further, we need to design quick ''phase 0'' clinical trials to eliminate the agents with little clinical potential. Thus, multidisciplinary efforts of researchers from diverse scientific disciplines are needed in order to take the most promising antioxidant agents from the bench to the bedside. Antioxid. Redox Signal. 19,[85][86][87][88] A delicate balance between oxidants and antioxidants is required for the normal functioning of living systems. A deregulation of this balance has been implicated in numerous diseases, including cancer, particularly in tumor initiation and tumor promotion. An understanding of redox signaling and its interactions with other biological processes during cancer development is important in identifying new targets toward developing novel means for cancer prevention and cancer therapeutics. At the same time, there is a crucial need to exploit the known redox-regulated pathways and targets to develop new agents for cancer management. The fundamental theme of this Forum revolves around (i) redox signaling-based molecular targets for cancer prevention and therapeutics, and (ii) novel antioxidants for cancer management. Three articles in this Forum (Bode and Dong, Kim et al., Wilking et al.) have discussed several important well-known as well as some emerging potential targets based on redox signaling and interactions (1,3,8). The other five articles (Khan et al., Li et al., Park and Pezzuto, Steinbrenner et al., Yum et al.) have discussed known and emerging antioxidants that may be useful in the prevention as well as treatment of cancer (2,4,5,7,9).In the first origi...

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Toward Understanding Success and Failures in the Use of Selenium for Cancer Prevention

Cited by 71 publications

References 92 publications

Epigenetic effects of selenium and their implications for health

Epigenetic effects of selenium and their implications for health

Meta-analysis of selenium accumulation and expression of antioxidant enzymes in chicken tissues

Antioxidants Meet Molecular Targets for Cancer Prevention and Therapeutics

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