Towards a catheter-based impedimetric sensor for the assessment of intestinal histamine levels in IBS patients

Wackers, Gideon; Putzeys, Tristan; Peeters, Marloes; Cauter, Lori Van de; Cornelis, Peter; Wübbenhorst, Michael; Tack, Jan; Troost, Freddy J.; Verhaert, Nicolas; Doll, Theodor; Wagner, Patrick

doi:10.1016/j.bios.2020.112152

Cited by 19 publications

(22 citation statements)

References 63 publications

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“…They coated titanium electrode wires in a catheter with an adhesive polystyrene layer onto which they immobilized both MIP and non-imprinted particles by dip coating in order to obtain a differential measurement setup (see Fig. 2 ) [ 85 ]. The resulting sensor was able to detect histamine in intestinal fluid in physiologically relevant concentrations, illustrating the potential of MIP-based sensing for in vivo monitoring gastro-intestinal disease markers.…”

Section: Mips As Receptors In Sensing Devicesmentioning

confidence: 99%

“…This patch, containing an integrated PDMS flow cell and a measuring chamber were attached to a test person’s arm, allowing to monitor lactate levels in sweat. Reproduced with permission from [ 85 ]. Copyright Elsevier 2020.…”

Section: Mips As Receptors In Sensing Devicesmentioning

confidence: 99%

“…The cross-linked nature of the polymer gives rise to distinct physical advantages over their biological counterparts. Enabling MIPs to resist harsh physical conditions (extreme pH and temperatures) that would render biological receptors useless [ [7] , [8] , [9] ]. This has led to MIPs being deployed into numerous fields, including chemical separation, chromatography, affinity materials for sensors, binding assays, catalysis, and sorbents for solid phase extraction, to name just a few [ [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] ].…”

Section: Introductionmentioning

confidence: 99%

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MIPs for commercial application in low-cost sensors and assays – An overview of the current status quo

Lowdon

Diliën

Singla

et al. 2020

Sensors and Actuators B: Chemical

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183

103

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Highlights The review aims to summarize recent commercially interesting innovations in MIP-based sensor design. In addition to sensors, commercially viable assays based on MIPs are analysed and recent advances are summarized and discussed. The review also analyses how commercial MIP companies could contribute to a next step in the commercialization of MIP-based detection systems. The review contains a critical analysis and discussion on MIP-based sensors and assay commercialization as well as an outlook/recommendation for the future.

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Section: Mips As Receptors In Sensing Devicesmentioning

confidence: 99%

Section: Mips As Receptors In Sensing Devicesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

MIPs for commercial application in low-cost sensors and assays – An overview of the current status quo

Lowdon

Diliën

Singla

et al. 2020

Sensors and Actuators B: Chemical

Self Cite

183

103

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“…For the mycotoxin deoxynivalenol [155], Nyquist plots determined charge transfer resistance (R ct ) increase with toxin MIP binding, response turned out to be log‐linear. An extreme demand on any sensor is use for in situ clinical monitoring, but the possibility has been shown in principle using an impedance catheter design for duodenal histamine in subjects with irritable bowel syndrome (IBS) [156]. A technically demanding broad frequency range was needed with convoluted data extraction using multiple equivalent circuits to obtain interference free resistive information signifying MIP binding.…”

Section: Mip Based Impedimetric Sensorsmentioning

confidence: 99%

Molecular Imprinted Polymer Modified Electrochemical Sensors for Small Drug Analysis: Progress to Practical Application

Feroz

Vadgama

2020

Electroanalysis

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Molecular imprinted polymers (MIPs) are tailor made from synthetic polymers and designed to mimic the recognition properties of natural biological affinity molecules. MIPs incorporate binding motifs complementary to target organic molecule shape and functional groups in order to mimic the complex binding surfaces of natural macromolecules. This confers selectivity and specificity, with the added advantage of artificial MIP polymer stability and ready adaptability to the fabrication and creation of miniaturised affinity interfaces for electrochemical sensing and extra‐laboratory testing. Their generic capability as robust sorbent phases for drug extraction and concentration allows for targeted, interfacial interrogation by the active electrochemical surface. A wide range of electrochemical sensing strategies has also been advanced in recent years, which is covered by this review. The review covers MIP functional principles, examples of MIP preparative routes and final assay outcomes for the measurement of small molecule drugs of biomedical, and also of potential environmental relevance. Some small molecules as examples of toxin and contaminant measurement are also given. A historic background to MIP development is provided, but the review mainly focuses on electrochemical sensor advances in the last five years.

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“…When amperometric electrodes, one of the electrochemical analytical methods, are utilized for HA determination, a high potential is necessary for a redox reaction with which to detect the current characteristics, and the redox product is unfavorable for the nervous system [ 21 , 22 ]. Although modern impedimetric electrodes, another electrochemical method, minimize unwanted cell depolarization with lower voltages [ 23 ], the complex models and analyses are not universal [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Solid-Contact Ion-Selective Electrodes for Histamine Determination

You

Zhang

et al. 2021

Sensors

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Solid-contact ion-selective electrodes for histamine (HA) determination were fabricated and studied. Gold wire (0.5 mm diameter) was coated with poly(3,4-ethlenedioxythiophene) doped with poly(styrenesulfonate) (PEDOT:PSS) as a solid conductive layer. The polyvinyl chloride matrix embedded with 5,10,15,20-tetraphenyl(porphyrinato)iron(iii) chloride as an ionophore, 2-nitrophenyloctyl ether as a plasticizer and potassium tetrakis(p-chlorophenyl) borate as an ion exchanger was used to cover the PEDOT:PSS layer as a selective membrane. The characteristics of the HA electrodes were also investigated. The detection limit of 8.58 × 10−6 M, the fast response time of less than 5 s, the good reproducibility, the long-term stability and the selectivity in the presence of common interferences in biological fluids were satisfactory. The electrode also performed stably in the pH range of 7–8 and the temperature range of 35–41 °C. Additionally, the recovery rate of 99.7% in artificial cerebrospinal fluid showed the potential for the electrode to be used in biological applications.

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Towards a catheter-based impedimetric sensor for the assessment of intestinal histamine levels in IBS patients

Cited by 19 publications

References 63 publications

MIPs for commercial application in low-cost sensors and assays – An overview of the current status quo

MIPs for commercial application in low-cost sensors and assays – An overview of the current status quo

Molecular Imprinted Polymer Modified Electrochemical Sensors for Small Drug Analysis: Progress to Practical Application

Solid-Contact Ion-Selective Electrodes for Histamine Determination

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