Towards a Long-Term Multi-Site Electrochemical Wound Monitoring System

Songkakul, Tanner; Bhushan, Pulak; Umasankar, Yogeswaran; Yokus, Murat A.; Daniele, Michael A.; Bhansali, Shekhar; Bozkurt, Alper

doi:10.1109/sensors43011.2019.8956636

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…Due to the persistent nature of P. aeruginosa infections, the ability to detect the presence of the bacteria would allow for early diagnosis and application of an appropriate treatment plan before the infection becomes too widespread. Wound pH is widely recognized as a key factor in wound healing and has been used as a basis for the development biosensors to detect infection and a number of previous investigators have used this as a basis for infection detection ( Songkakul et al, 2019 ; Kuo et al, 2020 ). Some have also included closed loop release of antimicrobials in the device design ( Mostafalu et al, 2018 ; Rivero et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Toward a Closed Loop, Integrated Biocompatible Biopolymer Wound Dressing Patch for Detection and Prevention of Chronic Wound Infections

Ward

Basnett

Lika

et al. 2020

Front. Bioeng. Biotechnol.

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Chronic wound infections represent a significant burden to healthcare providers globally. Often, chronic wound healing is impeded by the presence of infection within the wound or wound bed. This can result in an increased healing time, healthcare cost and poor patient outcomes. Thus, there is a need for dressings that help the wound heal, in combination with early detection of wound infections to support prompt treatment. In this study, we demonstrate a novel, biocompatible wound dressing material, based on Polyhydroxyalkanoates, doped with graphene platelets, which can be used as an electrochemical sensing substrate for the detection of a common wound pathogen, Pseudomonas aeruginosa . Through the detection of the redox active secondary metabolite, pyocyanin, we demonstrate that a dressing can be produced that will detect the presence of pyocyanin across clinically relevant concentrations. Furthermore, we show that this sensor can be used to identify the presence of pyocyanin in a culture of P. aeruginosa . Overall, the sensor substrate presented in this paper represents the first step toward a new dressing with the capacity to promote wound healing, detect the presence of infection and release antimicrobial drugs, on demand, to optimized healing.

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