Towards a simple, saliva-based test for the detection of oral cancer.

Wong, David T.

doi:10.1586/14737159.6.3.267

Cited by 81 publications

(30 citation statements)

References 35 publications

(36 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to the direct contact between saliva and oral cancer lesions, various salivary proteomes have been reported in the literature as potential biomarkers for oral cancer detection such as interleukin-8 (IL-8) [143–145], tumour necrosis factor-alpha, and salivary transferrin [146]. On the other hand, salivary soluble CD44 Ag can be used as a biomarker for head and neck squamous cell carcinoma [147], while the serum circulatory tumour markers, Cyfra 21-1 [148, 149], tissue polypeptide Ag, cancer Ag 125 [148], and salivary zinc finger protein 510 peptide [150], were identified as oral squamous cell carcinoma-related salivary biomarkers.…”

Section: Salivary Cancer Biomarkers and Biosensorsmentioning

confidence: 99%

Saliva-Based Biosensors: Noninvasive Monitoring Tool for Clinical Diagnostics

Malon

Sadir

Malarvili

et al. 2014

BioMed Research International

189

108

View full text Add to dashboard Cite

Saliva is increasingly recognised as an attractive diagnostic fluid. The presence of various disease signalling salivary biomarkers that accurately reflect normal and disease states in humans and the sampling benefits compared to blood sampling are some of the reasons for this recognition. This explains the burgeoning research field in assay developments and technological advancements for the detection of various salivary biomarkers to improve clinical diagnosis, management, and treatment. This paper reviews the significance of salivary biomarkers for clinical diagnosis and therapeutic applications, with focus on the technologies and biosensing platforms that have been reported for screening these biomarkers.

show abstract

Section: Salivary Cancer Biomarkers and Biosensorsmentioning

confidence: 99%

Saliva-Based Biosensors: Noninvasive Monitoring Tool for Clinical Diagnostics

Malon

Sadir

Malarvili

et al. 2014

BioMed Research International

189

108

View full text Add to dashboard Cite

show abstract

“…A critical factor in the lack of prognostic improvement is the fact that a significant proportion of cancers are initially asymptomatic lesions and are not diagnosed or treated until they reach an advanced stage. In OSCC, if the cancer is detected at T1 (T means the tumor size invasion level) stage, the 5 year survival rate is over 80%, compared to 20-40% if diagnosed at later stages (T3 and T4) (Wong 2006). Oral leukoplakia (OLK) is the most frequently occurring oral precancerous lesion and it has considerable malignant transformation in clinic (ranging from 1.58 to 27.27%) (Xu et al 1992).…”

Section: Introductionmentioning

confidence: 99%

“…Scientists expect to find high-throughput, low cost, more efficient and rapid diagnostic and screening approaches. Currently, the most definitive procedure for oral cancer diagnosis and screening involves a visit to the physician's office, a scalpel biopsy usually on the tongue or gums, followed by a histopathological evaluation (Wong 2006).…”

Section: Introductionmentioning

confidence: 99%

Urine metabolite profiling offers potential early diagnosis of oral cancer

et al. 2011

View full text Add to dashboard Cite

Abstract:Oral cancer is the sixth most common human cancer, with a high morbidity rate and an overall 5-year survival rate of less than 50%. It is often not diagnosed until it has reached an advanced stage. Therefore, an early diagnostic and stratification strategy is of great importance for oral cancer. In the current study, urine samples of patients with oral squamous cell carcinoma (OSCC, n = 37), oral leukoplakia (OLK, n = 32) and healthy subjects (n = 34) were analyzed by gas chromatography-mass spectrometry (GC-MS). Using multivariate statistical analysis, the urinary metabolite profiles of OSCC, OLK and healthy control samples can be clearly discriminated and a panel of differentially expressed metabolites was obtained. Metabolites, valine and 6-hydroxynicotic acid, in combination yielded an accuracy of 98.9%, sensitivity of 94.4%, specificity of 91.4%, and positive predictive value of 91.9% in distinguishing OSCC from the controls. The combination of three differential metabolites, 6-hydroxynicotic acid, cysteine, and tyrosine, was able to discriminate between OSCC and OLK with an accuracy of 92.7%, sensitivity of 85.0%, specificity of 89.7%, and positive predictive value of 91.9%. This study demonstrated that the metabolite markers derived from this urinary metabolite profiling approach may hold promise as a diagnostic tool for early stage OSCC and its differentiation from other oral conditions.

show abstract

“…ncbi.nlm.nih.gov/pmc/), web page for free on-line editions of magazines and papers. Also, part of the In recent medical past there are a lot of examples that show how the introduction and promotion of screening programs have a positive influence on the prognosis of some malignancies with high mortality (Pap test for early detection of cervical cancer, and mammography as a screening tool for breast cancer [3,5,12]). This year with a decision of the Government of the Republic of Macedonia, a Program for early detection of malignant diseases in Republic of Macedonia was prepared, which approves screening methods for three types of cancer: cervical cancer, breast cancer and colorectal cancer [13].…”

Section: Methodsmentioning

confidence: 99%

Understanding the Role of General Dentists in the Process of Screening and Early Diagnosis of Oral Premalignant And Malignant Lesions - Brief Literature Review

Gjurcheski

Popovic-Monevska²

2012

Maced J Med Sci

View full text Add to dashboard Cite

Aim: To indicate about the need for involving general dentists in the process of screening and early detection of malignant and premalignant lesions. To make brief literature review, which lesions are included under the term "oral premalignant lesions", and which lesions should be excluded from this nomenclature, according to the contemporary views and conceptions. To gather in one place the latest information about new diagnostic procedures used worldwide for screening and early diagnosis of premalignant and malignant lesions of oral mucosa.

show abstract

Towards a simple, saliva-based test for the detection of oral cancer.

Cited by 81 publications

References 35 publications

Saliva-Based Biosensors: Noninvasive Monitoring Tool for Clinical Diagnostics

Saliva-Based Biosensors: Noninvasive Monitoring Tool for Clinical Diagnostics

Urine metabolite profiling offers potential early diagnosis of oral cancer

Understanding the Role of General Dentists in the Process of Screening and Early Diagnosis of Oral Premalignant And Malignant Lesions - Brief Literature Review

Contact Info

Product

Resources

About