Towards a true prevalence of peptic ulcer: the Sorreisa gastrointestinal disorder study.

Abstract

This study, designed to overcome methodological problems inherent in earlier prevalence studies of peptic ulcer, was carried out in a municipality in northern Norway. It included the total population of 2027, aged 20-69 years, and comprised a questionnaire and search for previously diagnosed peptic ulcers in the local medical records for all subjects, and additional endoscopy of all subjects with dyspepsia and their matched healthy controls (n=619). The overall prevalence was 10*5% in men and 9'5% in women, a sex ratio close to one and a higher duodenal:gastric ratio than previously reported from this region. A substantial 1% prevalence of asymptomatic ulcers was also observed.

Are Genetic Influences on Peptic Ulcer Dependent or Independent of Genetic Influences for Helicobacter pylori Infection?

“…On the basis of endoscopic findings, one Norwegian study reported an overall prevalence of 7.4% in men and 4.6% in women. 31 Similar frequency estimates for lifetime prevalence of verified ulcers were found in an unselected Danish population initially identified with self-reported ulcer (7.7% among men and 3.6% among women 32 ). Another large cross-sectional questionnaire-based survey conducted in northern Norway reported a 5.3% prevalence of peptic ulcer in men and 2.1% in women.…”

Association between genetic polymorphisms in thecyclooxygenase-1 gene promoter and peptic ulcers in Japan

“…These findings indicated that NSAID users with no symptoms did not undergo endoscopic examinations. Bernersen et al reported that only 1% of asymptomatic subjects had peptic ulcer disease (20). Although 25 of the 47 studied NSAID users had gastric or duodenal ulcers (53.2%), Laine and colleagues showed in a recent study that the incidence of peptic ulcer disease was 4.9 and 14.3% in aspirin and NSAID users, respectively (21).…”

Perforated peptic ulcer disease: mid-term outcome among Iranian population

“…It has been shown that the incidence of peptic ulcer disease has generally declined, and its prevalence has been estimated as 5-10% in the adult population in different countries (1). However, the number of patients affected by bleeding and perforation has not changed significantly (2) such that perforated ulceration affects up to 20% of peptic ulcer disease patients (3).…”