Towards bacterial adhesion-based therapeutics and detection methods

Pera, Núria Parera; Pieters, Roland J.

doi:10.1039/c3md00346a

Cited by 24 publications

(18 citation statements)

References 64 publications

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“…The adhesion of bacteria, before infection, is frequently mediated by bacterial proteins and tissue carbohydrates; therefore, these interactions could be used to develop bacterial detection tools [65]. Rapid detection and classification of bacteria is of the utmost importance, as classic culture methods are time-consuming.…”

Section: Pathogen and Cell Isolationmentioning

confidence: 99%

Recent advances in biosensing using magnetic glyconanoparticles

2015

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In this critical review we discuss the most recent advances in the field of biosensing applications of magnetic glyconanoparticles. We first give an overview of the main synthetic routes to obtain magnetic-nanoparticle-carbohydrate conjugates and then we highlight their most promising applications for magnetic relaxation switching sensing, cell and pathogen detection, cell targeting and magnetic resonance imaging. We end with a critical perspective of the field, identifying the main challenges to be overcome, but also the areas where the most promising developments are likely to happen in the coming decades.

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Section: Pathogen and Cell Isolationmentioning

confidence: 99%

Recent advances in biosensing using magnetic glyconanoparticles

2015

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“…Effective antiadhesive therapy requires either high affinity monovalent lectin ligands capable of outperforming glycan clusters, or multivalent structures incorporating several copies of ligands of moderate affinity on a polyvalent scaffold (dendrimer, polymer, nanoparticle). Depending on the nature of the lectin involved, a large number of glycomimetic and neo-glycoconjugate structures have been proposed as antagonists of sugar-protein interaction events initiating bacterial and viral infections and recent comprehensive reviews are available [3][4][5][6]. Among the many reported examples, in this paper we will focus on two applications of the antiadhesive approach targeting the recognition of host glycans by a bacterial adhesin or the recognition of microbial glycans by a human lectin.…”

Section: Microbial Adhesion and Carbohydratesmentioning

confidence: 99%

Glycoconjugates and Glycomimetics as Microbial Anti-Adhesives

Sattin

Bernardi

2016

Trends in Biotechnology

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Microbial adhesion is an essential step of infections and is mediated primarily by proteincarbohydrate interactions. Antagonists of such interactions have become a promising target for antiadhesive therapy in a number of infective diseases. Monovalent protein-sugar interactions are often weak, and most successful antiadhesive materials consist of multivalent glycoconjugates.Although often very effective in hampering microbial adhesion, natural epitopes often show limited resistance to enzymatic degradation. The use of carbohydrate mimics (glycomimetics) as a replacement for natural sugars potentially allows to achieve higher metabolic stability and also higher selectivity towards the desired protein target. In this review we will describe the state of the art on the design and synthesis of glycoconjugates and glycomimetics employed for the construction of antiadhesive biomaterials.

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“…41 Numerous examples of glyconanomaterials that selectively bind to uropathogenic Escherichia coli with potential for pathogen identification and as antiadhesives to prevent infection and biofilm formation have been described. [42][43][44] More recently, trimeric cluster thiomannosides conjugated to diamond nanoparticles have been shown to inhibit type 1 fimbriae-mediated E. coli adhesion and biofilm formation 45 and mannose-coated singlewalled carbon nanotubes (SWCNTs) were able to reduce the colony formation of the E. coli strain ORN178 by 10%. 46 The carbohydrate-lectin mediated entry of pathogens has spurred the development of a large number of multivalent carbohydrate display systems including glyconanomaterials as potential inhibitors of this adhesion process.…”

Section: Inhibitors Of Pathogen Adhesionmentioning

confidence: 99%

Opportunities for glyconanomaterials in personalized medicine

2016

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In this feature article we discuss the particular relevance of glycans as components or targets of functionalized nanoparticles (NPs) for potential applications in personalized medicine but we will not enter into descriptions for their preparation. For a more general view covering the preparation and applications of glyconanomaterials the reader is referred to a number of recent reviews. The combination of glyco- and nanotechnology is already providing promising new tools for more personalized solutions to diagnostics and therapy. Current applications relevant to personalized medicine include drug targeting, localized radiation therapy, imaging of glycan expression of cancer cells, point of care diagnostics, cancer vaccines, photodynamic therapy, biosensors, and glycoproteomics.

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Towards bacterial adhesion-based therapeutics and detection methods

Abstract: Bacterial adhesion is an important first step towards bacterial infection and plays a role in colonization, invasion and biofilm formation.

Cited by 24 publications

References 64 publications

Recent advances in biosensing using magnetic glyconanoparticles

Recent advances in biosensing using magnetic glyconanoparticles

Glycoconjugates and Glycomimetics as Microbial Anti-Adhesives

Opportunities for glyconanomaterials in personalized medicine

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