2015
DOI: 10.1039/c4gc02289k
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Towards feasible and scalable solvent-free enzymatic polycondensations: integrating robust biocatalysts with thin film reactions

Abstract: There is an enormous potential for synthesizing novel bio-based functionalized polyesters under environmentally benign conditions by exploiting the catalytic efficiency and selectivity of enzymes. Despite the wide number of studies addressing in vitro enzymatic polycondensation, insufficient progress has been documented in the last two decades towards the preparative and industrial application of this methodology. The present study analyses bottlenecks hampering the practical applicability of enzymatic polycon… Show more

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Cited by 62 publications
(118 citation statements)
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“…The porosity of carriers seems to play a negligible role in the process design, rather, porosity might induce the risk of undesired occlusion by substrates and products, thus limiting the efficiency of the enzyme. This assumption is also supported by recent data obtained in polycondensation catalyzed by hydrolases immobilized on rice husk [59,66]. Although the enzymes (CaLB and Thc_cut1) were immobilized only on the surface either through adsorption-crosslinking or covalent bonding, the polyester synthesis proceeded with comparable rates and conversion as in the case of the macroporous methacrylic resins.…”
Section: Cutinases As Biocatalysts For Polymerization Reactionssupporting
confidence: 72%
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“…The porosity of carriers seems to play a negligible role in the process design, rather, porosity might induce the risk of undesired occlusion by substrates and products, thus limiting the efficiency of the enzyme. This assumption is also supported by recent data obtained in polycondensation catalyzed by hydrolases immobilized on rice husk [59,66]. Although the enzymes (CaLB and Thc_cut1) were immobilized only on the surface either through adsorption-crosslinking or covalent bonding, the polyester synthesis proceeded with comparable rates and conversion as in the case of the macroporous methacrylic resins.…”
Section: Cutinases As Biocatalysts For Polymerization Reactionssupporting
confidence: 72%
“…In the case of enzymatic polycondensation and more specifically in solvent-free systems, the viscosity of reaction mixtures makes the diffusion of substrates and pre-polymers into the pores highly unlikely [59]. The porosity of carriers seems to play a negligible role in the process design, rather, porosity might induce the risk of undesired occlusion by substrates and products, thus limiting the efficiency of the enzyme.…”
Section: Cutinases As Biocatalysts For Polymerization Reactionsmentioning
confidence: 99%
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“…However, the immobilized CALB can be recycled from the enzymatic polymerization and then reused for several cycles. [52][53][54] Moreover, N435…”
Section: Instrumental Methodsmentioning
confidence: 99%
“…(tpG) and the invertase from Saccharomyces cerevisiae (ISc) 17 . Overall, lipases have a wide industrial impact in the food, pharma and cosmetic sectors but their catalytic potential is far from being fully exploited for the production of commodities or biodiesel [19][20][21] . CaLB (3.1.1.3) is widely employed in the production of fine chemicals for its selectivity but also in the production of esters for body care sector.…”
Section: Functionalization Of Rh and Immobilization Of Enzymes Accordmentioning
confidence: 99%