Towards improved understanding of the hydrodynamics of a semi-partition bioreactor (SPB): A numerical investigation

Teke, George M.; Gakingo, Godfrey Kabungo; Pott, Robert William McClelland

doi:10.1016/j.cherd.2021.10.026

Cited by 13 publications

(5 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unlike the current approaches, an integrated fermentation methods could be vital for MEL separation and purification especially in cases where pretreatment of lignocellulosic biomass releases byproduct that inhibits microbial growth and limits productivity (Faria, Santos, Ferreira, Marques, et al, 2014;Santos et al, 2019;Zhang et al, 2015). Teke et al (2022a) highlighted the efficacy of solvent extraction (using experimental and computational modeling) with a semi-partitioning bioreactor (SPB) configuration that merges fermentation and separation within one unit (Teke et al, 2022a(Teke et al, , 2022bTeke et al, 2023;Teke & Pott, 2021). This departure from the conventional setup incorporates solvent extraction within the SPB offering a novel approach with potential application in MEL production, streamlining the recovery process while enhancing yield and recovery.…”

Section: Solvent Extractionmentioning

confidence: 99%

A review on the upstream production and downstream purification of mannosylerythritol lipids

Valkenburg,

Ncube,

Teke

et al. 2023

Biotech & Bioengineering

Self Cite

View full text Add to dashboard Cite

Biosurfactants are natural compounds with remarkable surface‐active properties that may offer an eco‐friendly alternative to conventional surfactants. Among them, mannosylerythritol lipids (MELs) stand out as an intriguing example of a glycolipid biosurfactant. MELs have been used in a variety of sectors for various applications, and are currently commercially produced. Industrially, they are used in the pharmaceutical, cosmetic, food, and agricultural industries, based on their ability to reduce surface tension and enhance emulsification. However, despite their utility, their production is comparatively limited industrially. From a bioprocessing standpoint, two areas of interest to improve the production process are upstream production and downstream (separation and purification) product recovery. The former has seen a significant amount of research, with researchers investigating several production factors: the microbial species or strain employed, the producing media composition, and the production strategy implemented. Improvement and optimization of these are key to scale‐up the production of MELs. On the other hand, the latter has seen comparatively limited work presented in the literature. For the most part traditional separation techniques have been employed. This systematic review presents the production and purification methodologies used by researchers by comprehensively analyzing the current state‐of‐the‐art with regards the production, separation, and purification of MELs. By doing so, the review presents different possible approaches, and highlights some potential areas for future work by identifying opportunities for the commercialization of MELs.

show abstract

Section: Solvent Extractionmentioning

confidence: 99%

A review on the upstream production and downstream purification of mannosylerythritol lipids

Valkenburg,

Ncube,

Teke

et al. 2023

Biotech & Bioengineering

Self Cite

View full text Add to dashboard Cite

show abstract

“…4) to aid the separation of several biomolecules based on liquid-liquid separation techniques. This method simplifies the configuration by incorporating the fermenter and the settler [82,154,155].…”

Section: Stirred Tank Bioreactorsmentioning

confidence: 99%

Extractive Fermentation Processes: Modes of Operation and Application

2021

Self Cite

View full text Add to dashboard Cite

Bioprocesses can be hampered by product concentrations within a fermentation leading to product‐inhibition, and reductions in yield and productivity. This limitation impacts operational considerations, process economics, and viability, and, ultimately, whether a technology is industrially viable. One approach to circumventing these concerns is in situ extraction of products. In this way, the organism is no longer exposed to the inhibitory product, and fermentation can proceed, often at improved rates. Significant advances in this field have been made in recent years, however, they are for the most part siloed into sub‐fields (focusing on the product extracted, or the method of extraction). This review considers in situ extraction more holistically in terms of i) the separation methodology, ii) the mode of reactor operation, and iii) the physical reactor configuration. The summary hopes to give insight into promising areas for research and potentially spark ideas for novel in situ extractive processes.

show abstract

“…Zhang et al performed numerical simulation on the residence time distributions in the multistage stirred reactor, 9 where the simulated RTD curves were evaluated under various operation conditions and reactor configurations. Haringa et al discussed the mixing in the stirred tanks equipped with multi-Rushton turbines based on the RANS method, 10 11 Their study suggests that the radial velocity at the opening surface between the chambers varies with time. Thus, the transient approach will be more accurate than the steady-state method to describe the mixing process.…”

Section: Introductionmentioning

confidence: 99%

“…Haringa et al discussed the mixing in the stirred tanks equipped with multi-Rushton turbines based on the RANS method, and their work indicated the presence of flow macro instabilities and a peak in the turbulent kinetic energy in the region of convergent flow. The numerical study of Teke et al focused on the use of validated simulations to investigate the hydrodynamics and mixing within the multistage stirred reactor . Their study suggests that the radial velocity at the opening surface between the chambers varies with time.…”

Section: Introductionmentioning

confidence: 99%

Residence Time Distribution and Flow Characteristic in a Multistage Stirred Reactor

Wang,

et al. 2023

Ind. Eng. Chem. Res.

View full text Add to dashboard Cite

Towards improved understanding of the hydrodynamics of a semi-partition bioreactor (SPB): A numerical investigation

Cited by 13 publications

References 65 publications

A review on the upstream production and downstream purification of mannosylerythritol lipids

A review on the upstream production and downstream purification of mannosylerythritol lipids

Extractive Fermentation Processes: Modes of Operation and Application

Residence Time Distribution and Flow Characteristic in a Multistage Stirred Reactor

Contact Info

Product

Resources

About