Towards quantitative demineralization imaging for the assessment of carious lesions based on PS-OCT

Golde, Jonas; Tetschke, Florian; Vosahlo, Robin; Kirsten, Lars; Walther, Julia; Hannig, Christian; Koch, Edmund

doi:10.1051/epjconf/202023804009

Cited by 5 publications

(5 citation statements)

References 2 publications

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“…A non-destructive complementary in vitro method for early caries detection is X-ray micro-computed tomography (micro-CT), which can determine mineral density and mineral loss [51][52][53]. Micro-CT scans are very time-consuming, the high-resolution 3D-images of micro-CT are comparable [51], as are the depolarization signals, which are in a good correlation with PS-OCT measurements [52], thus it has a low additional value to PS-OCT. Due to the numerous previous comparative studies that concluded that PS-OCT is well suited for the assessment of caries lesions [49,54] and its inhibition by anti-caries agents [55], we did not make a comparison in the presented study. In situ applications with PS-OCT are, so far, only possible to a limited extent.…”

Section: Discussionmentioning

confidence: 99%

Polarization-Sensitive Optical Coherence Tomography for Monitoring De- and Remineralization of Bovine Enamel In Vitro

Hund,

Golde,

Tetschke

et al. 2024

Diagnostics

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Early caries diagnosis still challenges dentistry. Polarization-sensitive optical coherence tomography (PS-OCT) is promising to detect initial lesions non-invasively in depth-resolved cross-sectional visualization. PS-OCT with determined degree of polarization (DOP) imaging provides an intuitive demineralization contrast. The aim of this study is to evaluate the suitability of DOP-based PS-OCT imaging to monitor controlled de- and remineralization progression for the first time and to introduce it as a valid, non-destructive in vitro detection method. Twelve standardized bovine enamel specimens were divided in different groups and demineralized with hydrochloric acid (HCl) as well as partly remineralized with fluoride over a 14-day pH-cycling experiment. The specimens were stored in artificial saliva and sodium chloride (NaCl), respectively. Progress measurements with PS-OCT were made with polarization-sensitive en faceand B-scan mode for qualitative evaluation. The specimens demineralized in HCl showed the most pronounced surface change (lowest DOP) and the most significant increase in depolarization. Additional fluoride treatment and the storage in artificial saliva resulted in the opposite (highest DOP). Therefore, DOP-based PS-OCT imaging appears to be a valuable technique for visualization and monitoring of enamel demineralization and remineralization processes in vitro. However, these findings need to be confirmed in human teeth ex vivo or in situ.

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Section: Discussionmentioning

confidence: 99%

Polarization-Sensitive Optical Coherence Tomography for Monitoring De- and Remineralization of Bovine Enamel In Vitro

Hund,

Golde,

Tetschke

et al. 2024

Diagnostics

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“…This combination of capabilities makes PS-OCT particularly effective for detecting early-stage carious lesions [ 31 ]. We have recently shown that depolarization imaging based on the degree of polarization (DOP) derived from PS-OCT measurements is able to detect early stages of enamel demineralization [ 32 – 34 ] and that it facilitates the differentiation of surface staining and discoloration from carious lesions [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

Visualization of carious lesions with polarized and depolarized light microscopy

Grundmann,

Golde,

Steuer

et al. 2024

Biomed. Opt. Express

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Polarized light microscopy (PLM) is an established method in dental histology for investigating the ultrastructure and carious process of teeth. This study introduces a novel approach for measuring the degree of polarization (DOP) in a modified PLM setup and uses the DOP to assess the changes of the optical properties of enamel and dentin due to caries. The validation is provided by a comparison with complementary imaging methods, i.e. standard PLM and µCT. The results show that demineralization is reliably displayed by the DOP in accordance with the common imaging methods, and that this quantitative analysis of depolarization allows the characterization of the different pathohistological zones of caries.

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“…computed tomography (CT), provides almost unlimited penetration and visualization of bony structures. Especially micro-CT (µCT) offers similar resolution and has been successfully used to validate OCT-based caries diagnostics of ex vivo tooth samples 11,12 or cardiac development models. 13 While µCT is limited to a small sample volume of several centimeters and thus not applicable for human imaging, cone-beam CT (CBCT) enables in vivo applications at the expense of resolving power.…”

Section: Introductionmentioning

confidence: 99%

Data-informed imaging: how radiography and shape models support endoscopic OCT imaging of the middle ear

Golde

Morgenstern²,

Liu³

et al. 2023

Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2023

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Endoscopic optical coherence tomography (OCT) enables the assessment of the eardrum and the middle ear in vivo. However, revealing the ossicles is often limited due to shadowing effects of preceding structures and the 3D impression is difficult to interpret. To compare the identified middle ear structures, OCT and cone-beam CT of a patient were spatially aligned and showed a good agreement in locating malleus and the promontory wall. As CT imaging uses ionizing radiation and is thus limited in application, we furthermore provide a concept how radiology can be utilized as a priori knowledge for OCT imaging. Therefore, a statistical shape model derived from μCT data of temporal bone specimens was fitted to in vivo OCT measurements, potentially providing a real-time augmentation of endoscopic OCT for middle ear diagnostics in the future.

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Towards quantitative demineralization imaging for the assessment of carious lesions based on PS-OCT

Cited by 5 publications

References 2 publications

Polarization-Sensitive Optical Coherence Tomography for Monitoring De- and Remineralization of Bovine Enamel In Vitro

Polarization-Sensitive Optical Coherence Tomography for Monitoring De- and Remineralization of Bovine Enamel In Vitro

Visualization of carious lesions with polarized and depolarized light microscopy

Data-informed imaging: how radiography and shape models support endoscopic OCT imaging of the middle ear

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