The purpose of this article is to check and identify management gaps that lead to the formation of digitalization problems in enterprises in the context of Industry 4.0 and to offer a conceptual approach to managing the development of high-tech enterprises in digital transformation. The paper substantiates the concept of digital transformation management in a high-tech enterprise based on interdependent adaptive systems for planning digital transformation processes, monitoring, and change management. The paper considers the idea of the Industry 4.0 concept and presents principal technologies and tools that contribute to the gradual transition to digital transformation. It is determined that digital transformation is a process of transition to digital business, which involves the use of digital technologies to change business processes in the company and provision of new opportunities for additional income and development prospects. A conceptual model of enterprise competitiveness formation in the process of digital transformation has been developed, which includes organizational and economical digital tools for sustainable development of high-tech enterprises and synergies from the organization of new forms of digital interaction. The proposed methodology for managing the development of high-tech enterprises in the context of digital transformation is based on the formation of an ecosystem model of decentralization in a single distributed digital space, based on interconnected adaptive systems of planning, monitoring, and change management, and, on the basis of modeling and forecasting of complex manufacturing and logistics processes of high-tech industries, it allows effective implementation of the innovative order portfolio in the short term and with limited opportunities while coordinating the priorities of the business strategy and strategy of digital transformation of high-tech enterprises.