Towards therapeutic advances in melanoma management: An overview

Singh, Smrita; Zafar, Atif; Khan, Shahper N.; Naseem, Imrana

doi:10.1016/j.lfs.2017.02.011

Cited by 52 publications

(38 citation statements)

References 67 publications

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“…Melanoma is one of the most aggressive cancers and it has an increasing incidence worldwide [1]. Similar to other tumors, melanoma contains cancer stem cells (CSC).…”

Section: Introductionmentioning

confidence: 99%

Lipid Storage and Autophagy in Melanoma Cancer Cells

Giampietri

Petrungaro

Cordella

et al. 2017

IJMS

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Cancer stem cells (CSC) represent a key cellular subpopulation controlling biological features such as cancer progression in all cancer types. By using melanospheres established from human melanoma patients, we compared less differentiated melanosphere-derived CSC to differentiating melanosphere-derived cells. Increased lipid uptake was found in melanosphere-derived CSC vs. differentiating melanosphere-derived cells, paralleled by strong expression of lipogenic factors Sterol Regulatory Element-Binding Protein-1 (SREBP-1) and Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ). An inverse relation between lipid-storing phenotype and autophagy was also found, since microtubule-associated protein 1A/1B-Light Chain 3 (LC3) lipidation is reduced in melanosphere-derived CSC. To investigate upstream autophagy regulators, Phospho-AMP activated Protein Kinase (P-AMPK) and Phospho-mammalian Target of Rapamycin (P-mTOR) were analyzed; lower P-AMPK and higher P-mTOR expression in melanosphere-derived CSC were found, thus explaining, at least in part, their lower autophagic activity. In addition, co-localization of LC3-stained autophagosome spots and perilipin-stained lipid droplets was demonstrated mainly in differentiating melanosphere-derived cells, further supporting the role of autophagy in lipid droplets clearance. The present manuscript demonstrates an inverse relationship between lipid-storing phenotype and melanoma stem cells differentiation, providing novel indications involving autophagy in melanoma stem cells biology.

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“…Melanoma is one of the most aggressive cancers and it has an increasing incidence worldwide [1]. Similar to other tumors, melanoma contains cancer stem cells (CSC).…”

Section: Introductionmentioning

confidence: 99%

Lipid Storage and Autophagy in Melanoma Cancer Cells

Giampietri

Petrungaro

Cordella

et al. 2017

IJMS

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“…Malignant melanoma is the most serious type of skin cancer and develops in melanocytes that produce melanin pigment (1). The most common site of malignant melanoma is the upper back, although it also occurs in the arms and legs (2).…”

Section: Introductionmentioning

confidence: 99%

Moringa oleifera fruit induce apoptosis via reactive oxygen species-dependent activation of mitogen-activated protein kinases in human melanoma A2058 cells

Guon

Chung

2017

Oncology Letters

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Abstract. The present study was performed to determine the effect of Moringa oleifera fruit extract on the apoptosis of human melanoma A2058 cells. A2058 cells were treated for 72 h with Moringa oleifera fruit extract at 50-100 µg/ml, and cell viability with apoptotic changes was examined. The involvement of reactive oxygen species (ROS) and mitogen-activated protein kinases (MAPKs) was examined. It was revealed that Moringa oleifera fruit extract significantly inhibited the cell viability and promoted apoptosis of A2058 cells in a concentration-dependent manner. Moringa oleifera fruit extract-treated A2058 cells exhibited increased activities of cleaved caspase-9 and caspase-3. It also caused an enhancement of MAPK phosphorylation and ROS production. The pro-apoptotic activity of Moringa oleifera fruit extract was significantly reversed by pretreatment with the c-Jun N-terminal kinase (JNK) inhibitor SP600125, extracellular-signal-regulated kinase (ERK) inhibitor PD98058 or ROS inhibitor N-acetyl-L-cysteine. Taken together, Moringa oleifera fruit extract is effective in inducing mitochondrial apoptosis of A2058 cells, which is mediated through induction of ROS formation, and JNK and ERK activation. Moringa oleifera fruit extract may thus have therapeutic benefits for human melanoma A2058 cells.

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“…Malignant cutaneous melanoma (MCM) is an extremely aggressive and deadly form of cancer that arises from the malignant proliferation of melanocytes transformation in Cutaneous, upper back mucous membranes, and eyes, as well as central nervous system (CNS) . In recent decades, a large number of studies indicated that MCM has now become a public health problem, since its prevalence has increased dramatically over the past decade, at an alarming rate between caucasians race with high mortality rates all over the world .…”

Section: Introductionmentioning

confidence: 99%

Nickel oxide nanoparticles exert selective toxicity on skin mitochondria and lysosomes isolated from the mouse model of melanoma

Rahimi

Naserzadeh

Mousavi

et al. 2019

J Biochem & Molecular Tox

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Nickel oxide nanoparticles (NiO‐NPs) are progressively used for an immense number of new applications in modern industries sectors. Nevertheless, the toxic impact of NiO‐NPs has not been clearly elucidated on human melanoma cell lines at the cellular and molecular level. Hence, this study was designed to examine the in vitro cytotoxicity potentials of NiO‐NPs on malignant cutaneous melanoma (MCM) mitochondria. Results revealed that NiO‐NPs significantly increased reactive oxygen species level, lipid peroxidation, and mitochondrial membrane potential and decreased succinate dehydrogenase activity, glutathione level, and ATP content on skin mitochondria isolated from the mouse model of melanoma compared with the non‐cancerous mouse skin mitochondria. Our results revealed that NiO‐NPs induced lysosomal membrane labialization on mentioned mitochondria. The current study showed that NiO‐NPs could significantly induce selective cytotoxicity on MCM mitochondria. Therefore, this compound may be considered as a promising candidate for further in vivo and clinical studies to reach a new anti‐MCM drug.

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Towards therapeutic advances in melanoma management: An overview

Cited by 52 publications

References 67 publications

Lipid Storage and Autophagy in Melanoma Cancer Cells

Lipid Storage and Autophagy in Melanoma Cancer Cells

Moringa oleifera fruit induce apoptosis via reactive oxygen species-dependent activation of mitogen-activated protein kinases in human melanoma A2058 cells

Nickel oxide nanoparticles exert selective toxicity on skin mitochondria and lysosomes isolated from the mouse model of melanoma

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