Towards understandings of serine/arginine-rich splicing factors

Li, D.; Yu, Wenying; Lai, Maode

doi:10.1016/j.apsb.2023.05.022

Cited by 22 publications

(7 citation statements)

References 253 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This strategy has proven effective in repairing the coding sequence of the DMD causative gene in animal models [72] and also provides a new method for MSTN gene knockout in pigs [73]. An interesting observation in our study is that, consistent with the majority of alternative splicing classifications [2,74,75], we divided AS events into five types. However, in some analyses, AS events were categorized into seven classes, including an additional two events: alternative first exon (AF) and alternative last exon (AL) events [76][77][78][79].…”

Section: Discussionmentioning

confidence: 77%

Exploring Multi-Tissue Alternative Splicing and Skeletal Muscle Metabolism Regulation in Obese- and Lean-Type Pigs

Wang,

Li,

Liu

et al. 2024

Genes

View full text Add to dashboard Cite

Alternative splicing (AS) is a crucial mechanism in post-transcriptional regulation, contributing significantly to the diversity of the transcriptome and proteome. In this study, we performed a comprehensive AS profile in nine tissues obtained from Duroc (lean-type) and Luchuan (obese-type) pigs. Notably, 94,990 AS events from 14,393 genes were identified. Among these AS events, it was observed that 80% belonged to the skipped exon (SE) type. Functional enrichment analysis showed that genes with more than ten AS events were closely associated with tissue-specific functions. Additionally, the analysis of overlap between differentially alternative splicing genes (DSGs) and differentially expressed genes (DEGs) revealed the highest number of overlapped genes in the heart and skeletal muscle. The novelty of our study is that it identified and validated three genes (PYGM, MAPK11 and CAMK2B) in the glucagon signaling pathway, and their alternative splicing differences were highly significant across two pig breeds. In conclusion, our study offers novel insights into the molecular regulation of diverse tissue physiologies and the phenotypic differences between obese- and lean-type pigs, which are helpful for pig breeding.

show abstract

Section: Discussionmentioning

confidence: 77%

Exploring Multi-Tissue Alternative Splicing and Skeletal Muscle Metabolism Regulation in Obese- and Lean-Type Pigs

Wang,

Li,

Liu

et al. 2024

Genes

View full text Add to dashboard Cite

show abstract

“…Efforts to modulate tissue-specific splicing can involve targeting trans -acting splicing factors with small molecules. 26,100,109 Among the most promising developments are PROTACs and molecular glues, both of which promoting proteasome-mediated degradation of the target. 103,151 These drug agents can induce almost complete protein degradation even when present at substochiometric concentration with respect to the target splicing factor.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, splicing activators such as the splicing factor SRSF6 are known to be overexpressed in various cancers, correlating with poor prognostic outcomes. 100 Studies have demonstrated that SRSF6 promotes colorectal cancer (CRC) proliferation, migration, and invasion in vitro , as well as tumor development and metastasis in NOD/SCID mice. 101 SRSF6 contributes to tumorigenesis by modulating the alternative splicing of key tumor-associated genes, including ZO-1 exon 23, a critical cell adhesion molecule.…”

Section: Small Molecules Targeting Trans-splicing Factorsmentioning

confidence: 99%

Small molecules modulating RNA splicing: a review of targets and future perspectives

Bouton,

Ecoutin,

Malard

et al. 2024

RSC Med. Chem.

View full text Add to dashboard Cite

show abstract

“…hnRNPs possess one or two RNA recognition motif (RRM) domains, alongside unstructured domains that enable them to regulate their interactions with other proteins (Krecic & Swanson, 1999). Similarly, SR proteins feature RNA recognition motif domains at their amino terminus, allowing for RNA‐binding specificity, and a carboxy‐terminal arginine/serine‐rich (RS) domain that impacts their interactions with other proteins (Li et al, 2023; Long & Caceres, 2009). Both families of splicing factors undergo post‐translational modifications, which play a crucial role in governing their cellular localization, RNA binding affinity, and protein–protein interactions (Galganski et al, 2017).…”

Section: Pre‐mrna Splicingmentioning

confidence: 99%

The spectrum of pre‐mRNA splicing in autism

Engal,

Zhang,

Geminder

et al. 2024

WIREs RNA

View full text Add to dashboard Cite

Disruptions in spatiotemporal gene expression can result in atypical brain function. Specifically, autism spectrum disorder (ASD) is characterized by abnormalities in pre‐mRNA splicing. Abnormal splicing patterns have been identified in the brains of individuals with ASD, and mutations in splicing factors have been found to contribute to neurodevelopmental delays associated with ASD. Here we review studies that shed light on the importance of splicing observed in ASD and that explored the intricate relationship between splicing factors and ASD, revealing how disruptions in pre‐mRNA splicing may underlie ASD pathogenesis. We provide an overview of the research regarding all splicing factors associated with ASD and place a special emphasis on five specific splicing factors—HNRNPH2, NOVA2, WBP4, SRRM2, and RBFOX1—known to impact the splicing of ASD‐related genes. In the discussion of the molecular mechanisms influenced by these splicing factors, we lay the groundwork for a deeper understanding of ASD's complex etiology. Finally, we discuss the potential benefit of unraveling the connection between splicing and ASD for the development of more precise diagnostic tools and targeted therapeutic interventions.This article is categorized under: RNA in Disease and Development > RNA in Disease RNA Evolution and Genomics > RNA and Ribonucleoprotein Evolution RNA Evolution and Genomics > Computational Analyses of RNA RNA‐Based Catalysis > RNA Catalysis in Splicing and Translation

show abstract

Towards understandings of serine/arginine-rich splicing factors

Cited by 22 publications

References 253 publications

Exploring Multi-Tissue Alternative Splicing and Skeletal Muscle Metabolism Regulation in Obese- and Lean-Type Pigs

Exploring Multi-Tissue Alternative Splicing and Skeletal Muscle Metabolism Regulation in Obese- and Lean-Type Pigs

Small molecules modulating RNA splicing: a review of targets and future perspectives

The spectrum of pre‐mRNA splicing in autism

Contact Info

Product

Resources

About