2016
DOI: 10.1016/j.bbagrm.2016.04.005
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TOX3 regulates neural progenitor identity

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Cited by 19 publications
(11 citation statements)
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“…Among the TFs that exhibit MR activity in Cluster 17, were Sirtuin 2 ( Sirt2 ), an NAD‐dependent histone deacetylase specifically expressed in oligodendrocytes to modulate the cytoskeleton during differentiation and maturation and the NK2 Homeobox 2 ( Nkx2‐2 ) homeodomain TF, a well‐known MR of cell fate determination and differentiation in the oligodendrocyte lineage (Figure S3d) (Qi et al, 2001; Tang & Chua, 2008). The MRs activated in Cluster 23 included, TOX High Mobility Group Box Family Member 3 ( Tox3 ), a TF regulating neural progenitor identity, and Forkhead Box P2 ( Foxp2 ), a TF crucial for specialized neuronal activities (Figure S3e) (Enard, 2011; Sahu et al, 2016). Finally, the TFs acting as specific MRs of Cluster 22 include TEA Domain Transcription Factor 1 ( Tead1 ) and Smad family member 3 ( Smad3 ) (Figure 4b).…”
Section: Resultsmentioning
confidence: 99%
“…Among the TFs that exhibit MR activity in Cluster 17, were Sirtuin 2 ( Sirt2 ), an NAD‐dependent histone deacetylase specifically expressed in oligodendrocytes to modulate the cytoskeleton during differentiation and maturation and the NK2 Homeobox 2 ( Nkx2‐2 ) homeodomain TF, a well‐known MR of cell fate determination and differentiation in the oligodendrocyte lineage (Figure S3d) (Qi et al, 2001; Tang & Chua, 2008). The MRs activated in Cluster 23 included, TOX High Mobility Group Box Family Member 3 ( Tox3 ), a TF regulating neural progenitor identity, and Forkhead Box P2 ( Foxp2 ), a TF crucial for specialized neuronal activities (Figure S3e) (Enard, 2011; Sahu et al, 2016). Finally, the TFs acting as specific MRs of Cluster 22 include TEA Domain Transcription Factor 1 ( Tead1 ) and Smad family member 3 ( Smad3 ) (Figure 4b).…”
Section: Resultsmentioning
confidence: 99%
“…Our work in granulosa cells showed that TOX3 exerts an antiapoptotic effect on ovarian granulosa cells. In previous studies, TOX3 has been demonstrated to be a survival factor (12) or a pro-proliferation factor (14,38) in several biological processes. TOX3 also upregulates a set of ER target genes that are involved in the cell cycle, cancer progression, and metastasis (14).…”
Section: Discussionmentioning
confidence: 99%
“…The lack of volume differences supports previous findings ( 12 15 ), suggesting that RLS is not accompanied by any changes of subcortical gray matter. Instead, it seems more likely that alterations of the dopaminergic system ( 6 ), possibly induced by genes involved in neurodevelopment [ MEIS1 ( 35 , 36 ) and TOX3 ( 37 )], protection of dopaminergic neurons [ MAP2K5 ( 38 )], sleep disturbances [ BTBD9 ( 39 )], modulation of dopaminergic neurotransmission [ PTPRD ( 40 )], and iron regulation within the brain [ BTBD9 ( 41 )], may lead to changes in functional brain networks. In particular, increased functional connectivity has been reported in sensory-thalamic, basal ganglia-thalamic, and other cortical and subcortical networks in patients with RLS, whereas symptom severity correlated with increased network connectivity ( 42 ).…”
Section: Discussionmentioning
confidence: 99%