Toxic activities of venoms from nine Bothrops species and their correlation with lethality and necrosis

Ferreira, Mônica Lopes; Moura-da-Silva, Ana Maria; França, Francisco Oscar de Siqueira; Cardoso, João Luiz Costa; Mota, I.

doi:10.1016/0041-0101(92)90032-z

Cited by 60 publications

(33 citation statements)

References 12 publications

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“…Other less common effects include intravascular haemolysis, acute myocardial damage multiple organ failure, and death. The clinical features of the envenomation are affected by the venom components, which vary according to snake species, geographic region, age, sex, and environment [5, 8, 9]. …”

Section: Introductionmentioning

confidence: 99%

Biochemical Characterization, Action on Macrophages, and Superoxide Anion Production of Four Basic Phospholipases A₂from PanamanianBothrops asperSnake Venom

Rueda

Rodríguez

Arantes

et al. 2013

BioMed Research International

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Bothrops asper (Squamata: Viperidae) is the most important venomous snake in Central America, being responsible for the majority of snakebite accidents. Four basic PLA2s (pMTX-I to -IV) were purified from crude venom by a single-step chromatography using a CM-Sepharose ion-exchange column (1.5 × 15 cm). Analysis of the N-terminal sequence demonstrated that pMTX-I and III belong to the catalytically active Asp49 phospholipase A2 subclass, whereas pMTX-II and IV belong to the enzymatically inactive Lys49 PLA2s-like subclass. The PLA2s isolated from Panama Bothrops asper venom (pMTX-I, II, III, and IV) are able to induce myotoxic activity, inflammatory reaction mainly leukocyte migration to the muscle, and induce J774A.1 macrophages activation to start phagocytic activity and superoxide production.

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Section: Introductionmentioning

confidence: 99%

Biochemical Characterization, Action on Macrophages, and Superoxide Anion Production of Four Basic Phospholipases A₂from PanamanianBothrops asperSnake Venom

Rueda

Rodríguez

Arantes

et al. 2013

BioMed Research International

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“…The non-proteic fraction is made up of carbohydrates, lipids, metals, biogenic amines, free amino acids and nucleotides [1,6,8,9]. The bothropic venom varies in its composition among the same species from different geographic regions, due to dietetic availability, and even in the same animal, depending on its age [1,9,15,16,17,18,19,20]. Despite venom variability, some basic actions are universal to all Bothrops species.…”

Section: Bothropic Accident Clinical Picturementioning

confidence: 99%

Acute Kidney Injury Caused by <i>Bothrops</i> Snake Venom

Sgrignolli¹,

Mendes²,

Carlos³

et al. 2011

Nephron Clin Pract

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Medically important venomous snakes in Latin America belong to the genus Bothrops, Crotalus, Lachesis and Micrurus. The Bothrops genus is responsible for the majority of accidents. The WHO globally estimates 2,500,000 poisonous snakebites and 125,000 deaths annually. In its last report in 2001, the Brazilian Ministry of Health accounted 359 deaths due to snakebites, of which the Bothrops genus was responsible for 185. Snake venoms cause local and systemic damage, including acute kidney injury, which is the most important cause of death among patients surviving the early effects of envenoming by the Crotalus and Bothrops genuses. Venom-induced acute kidney injury is a frequent complication of Bothrops snakebite, carrying relevant morbidity and mortality.

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“…Among Latin America venomous snakes, those of the Bothrops genus are responsible for approximately 90% of ophidian accidents (Ferreira T 1992) [1] (Ribeiro RAMB 1998) [2]. These envenomations are characterized by prominent local tissue damage due to myonecrosis, hemorrhage, and edema (Rosenberg HT 1990) [3].…”

Section: Introductionmentioning

confidence: 99%

Crystallization and Preliminary X-Ray Crystallographic Studies of a Myotoxic Lys49-phospholipase A2 from Bothrops jararacussu Venom Complexed with α-Tocopherol Inhibitor

Takeda¹,

Santos²,

Marchi-Salvador³

et al. 2008

TOCRYJ

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Bothropstoxin I (BthTX-I), a non-catalytic and myotoxic Lys49-PLA 2 from Bothrops jararacussu venom, has been crystallized alone and complexed with -tocopherol inhibitor. These crystals have been shown to diffract X-rays between 2.17 and 1.83 Å resolution. The BthTX-I/ -tocopherol complex crystals are not isomorphous with those of the native protein. This suggests the inhibitor binding has lead to changes in the quaternary structure and a different conformation may have been obtained.

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Toxic activities of venoms from nine Bothrops species and their correlation with lethality and necrosis

Cited by 60 publications

References 12 publications

Biochemical Characterization, Action on Macrophages, and Superoxide Anion Production of Four Basic Phospholipases A₂from PanamanianBothrops asperSnake Venom

Biochemical Characterization, Action on Macrophages, and Superoxide Anion Production of Four Basic Phospholipases A₂from PanamanianBothrops asperSnake Venom

Acute Kidney Injury Caused by <i>Bothrops</i> Snake Venom

Crystallization and Preliminary X-Ray Crystallographic Studies of a Myotoxic Lys49-phospholipase A2 from Bothrops jararacussu Venom Complexed with α-Tocopherol Inhibitor

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Toxic activities of venoms from nine Bothrops species and their correlation with lethality and necrosis

Cited by 60 publications

References 12 publications

Biochemical Characterization, Action on Macrophages, and Superoxide Anion Production of Four Basic Phospholipases A2from PanamanianBothrops asperSnake Venom

Biochemical Characterization, Action on Macrophages, and Superoxide Anion Production of Four Basic Phospholipases A2from PanamanianBothrops asperSnake Venom

Acute Kidney Injury Caused by <i>Bothrops</i> Snake Venom

Crystallization and Preliminary X-Ray Crystallographic Studies of a Myotoxic Lys49-phospholipase A2 from Bothrops jararacussu Venom Complexed with α-Tocopherol Inhibitor

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Biochemical Characterization, Action on Macrophages, and Superoxide Anion Production of Four Basic Phospholipases A₂from PanamanianBothrops asperSnake Venom

Biochemical Characterization, Action on Macrophages, and Superoxide Anion Production of Four Basic Phospholipases A₂from PanamanianBothrops asperSnake Venom