Toxic effect of gestational exposure to nonylphenol on F1 male rats

Abstract

Gestational exposure to nonylphenol might induce neurotoxic and reproductive toxic effects on F1 male rats.

Nonylphenol aggravates non-alcoholic fatty liver disease in high sucrose-high fat diet-treated rats

“…For example, NP exposure doses changed from 50 mg/kg/day to 200 mg/kg/day in our toxicological studies 46,47 . Specifically, our previous study shown that the concentration of NP measured in Xiangjiang River in Zunyi of China ranges from 0.174 to 3.411 μg/L 48 .…”

Zinc deficiency with reduced mastication impairs spatial memory in young adult mice

“…The spatial memory and learning parameters were defined according to the following criteria [11]: 1) escape latency, or duration to find the platform; 2) number of failures to reach the goal, or the total number of times the mouse failed to find the platform within 60 sec in four trials per day; 3) staying time in the quadrant of the goal area, or the cumulative time spent in the quadrant including the goal in the probe test.…”

Antiandrogenic and Estrogenic Compounds: Effect on Development and Function of Male Reproductive System

“…In the lamb, it was demonstrated to inhibit the secretion of FSH in the fetus with a concomitant decrease in testis size and Sertoli cell number at birth (Sweeney et al, 2000). In adult males exposed in utero or neonatally to alkylphenols abnormalities in reproductive organs histology, reduced weight of the testis, epididymis and prostate, reduced testosterone level as well as increased number of abnormal sperm and decreased sperm production were observed (Aydoğan & Barlas, 2006;Jie et al, 2010;Lee, 1998;Yoshida et al, 2001). These alterations may result from both modulation of the hypothalamus-pituitary axis and direct estrogenic action in reproductive tissues (Yoshida et al, 2001).…”