Zinc deficiency with reduced mastication impairs spatial memory in young adult mice

Kida, Kumiko; Tsuji, Taichi; Tanaka, Susumu; Kogo, Mikihiko

doi:10.1016/j.physbeh.2015.10.005

Cited by 10 publications

(10 citation statements)

References 24 publications

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“…Damage of one or both parts of the hippocampus causes behavioral changes and deficits in learning about people, places, and objects (Bannerman et al, 2002;Vitolo et al, 2002;Longoni et al, 2015). Although Zn deficiency can alter spatial learning and memory by changing neurotransmitter content and receptor activity (Halas et al, 1983;Sandstead, 1985;Halas et al, 1986;Golub et al, 1995;Keller et al, 2001;Bitanihirwe and Cunningham, 2009;Kida et al, 2015), excess Zn induces central nervous system (CNS) pathology (Hamadani et al, 2002;Tamura et al, 2003;Flinn et al, 2005;Bitanihirwe and Cunningham, 2009;Contestabile et al, 2016;Tabrizian et al, 2016). Indeed, high levels of Zn can induce apoptosis and cytotoxicity in neural cells (Bitanihirwe and Cunningham, 2009).…”

Section: Introductionmentioning

confidence: 99%

Effects of Quercetin and Resveratrol on Zinc Chloride- and Sodium Metavanadate-Induced Passive Avoidance Memory Retention Deficits in Male Mice

Hashemzaei

Fanoudi

Najari

et al. 2021

Prev. Nutr. Food Sci.

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Quercetin and resveratrol are found in a variety of fruits and vegetables and have several biological and pharmacological properties. In this study, the effects of quercetin [50 mg/kg, intraperitoneal (i.p.)] and resveratrol (50 mg/kg, i.p.) on zinc chloride (ZnCl2; 75 mg/kg/d, 2 weeks oral gavage) and sodium metavanadate (SMV; 22.5 mg/kg/d, 2 weeks oral gavage) induced passive avoidance memory retention were investigated in step-through passive avoidance tasks. ZnCl2 was dissolved in saline and SMV was dissolved in drinking water. Mice received ZnCl2 or SMV orally for two weeks and were administered quercetin or resveratrol by i.p. injection on day 14, days 12 and 14, or days 10, 12, and 14. At the end of treatment, animals were trained for one day in a step-through passive avoidance task, then alterations in avoidance memory retention were evaluated after 24, 48, 96, and 168 h. Oral consumption of ZnCl2 and SMV decreased latency time compared with control groups. Both quercetin and resveratrol (50 mg/kg, i.p.) prevented ZnCl2-and SMV-induced avoidance memory retention impairments and did not significantly alter muscle strength, as demonstrated in rotarod tasks. No significant differences were observed between mice who received single, double, or triple doses of quercetin or resveratrol. The results suggest that quercetin and resveratrol may have preventive effects on ZnCl2-and SMV-induced memory impairment in male mice.

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Section: Introductionmentioning

confidence: 99%

Effects of Quercetin and Resveratrol on Zinc Chloride- and Sodium Metavanadate-Induced Passive Avoidance Memory Retention Deficits in Male Mice

Hashemzaei

Fanoudi

Najari

et al. 2021

Prev. Nutr. Food Sci.

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“…Genotypes of mice were determined via RT-PCR using tail samples. Each mouse was housed in an individual cage in a controlled environment with a temperature of 23 °C, 60% humidity, and light and dark periods every 12 h and fed ad libitum on solid feed (MF: Oriental Yeast, Tokyo, Japan) [ 39 ].…”

Section: Methodsmentioning

confidence: 99%

Analysis of Feeding Behavior Characteristics in the Cu/Zn Superoxide Dismutase 1 (SOD1) SOD1G93A Mice Model for Amyotrophic Lateral Sclerosis (ALS)

et al. 2023

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Amyotrophic lateral sclerosis (ALS) is a progressive disease affecting upper and lower motor neurons. Feeding disorders are observed in patients with ALS. The mastication movements and their systemic effects in patients with ALS with feeding disorders remain unclear. Currently, there is no effective treatment for ALS. However, it has been suggested that treating feeding disorders and improving nutritional status may prolong the lives of patients with ALS. Therefore, this study elucidates feeding disorders observed in patients with ALS and future therapeutic agents. We conducted a temporal observation of feeding behavior and mastication movements using an open-closed mouth evaluation artificial intelligence (AI) model in an ALS mouse model. Furthermore, to determine the cause of masticatory rhythm modulation, we conducted electrophysiological analyses of mesencephalic trigeminal neurons (MesV). Here, we observed the modulation of masticatory rhythm with a prolonged open phase in the ALS mouse model from the age of 12 weeks. A decreased body weight was observed simultaneously, indicating a correlation between the prolongation of the open phase and the decrease observed. We found that the percentage of firing MesV was markedly decreased. This study partially clarifies the role of feeding disorders in ALS.

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“…27 Additional factors, such as the type of diet, 28 have been investigated for their association with the observed cognitive deficits in animals. 28,29 Nutrient intake may also be considered an individual risk factor, and it may explain at least part of the masticatory functions of an individual. 30…”

Section: Chewing Function and Maximum Occlusal Force In Older People And People With Dementiamentioning

confidence: 99%

“…Despite evidence of a correlation between cognitive decline/dementia and impaired chewing function, 1,[24][25][26] a causal relationship remains to be demonstrated. 27 Additional factors, such as the type of diet, 28 have been investigated for their association with the observed cognitive deficits in animals. 28,29 Nutrient intake may also be considered an individual risk factor, and it may explain at least part of the masticatory functions of an individual.…”

Section: Chewing Function and Maximum Occlusal Force In Older People ...mentioning

confidence: 99%

Chewing function and related parameters as a function of the degree of dementia: Is there a link between the brain and the mouth?

2021

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Background To date, no study has investigated the association between chewing function and related parameters as a function of the degree of dementia using a finer subdivision of the values of the Mini‐Mental State Examination (MMSE). Objective This study aimed to investigate the differences in chewing function and related parameters as a function of the degree of dementia. Methods An analysis of cross‐sectional data obtained from the OrBiD (Oral Health, Bite Force, and Dementia) pilot study was performed. The participants were stratified into five groups based on the outcomes of the MMSE (no dementia, MMSE 28–30; mild cognitive impairment, MMSE 25–27; mild dementia, MMSE 18–24; moderate dementia, MMSE 10–17; severe dementia, MMSE <10). The chewing efficiency, maximum occlusal force and related parameters (number of supporting zones, number of teeth, Eichner index, tooth/denture status, denture quality, and dental treatment needs) were recorded. Results The MMSE groups showed significantly different chewing efficiencies (p = .003, Jonckheere‐Terpstra test) and maximum occlusal forces (p = .003, Jonckheere‐Terpstra test), but the number of supporting zones (p = .055, chi‐square test) and the number of natural teeth (p = .126, chi‐square test) were not different. The Eichner index, tooth/denture status, denture quality and dental treatment need showed no significant associations with the degree of dementia. Conclusion An improvement in the usability of the measurement methods for assessing chewing function in people with dementia is needed. Research involving people with dementia is necessary because the nutritional situation often deteriorates rapidly within a multifactorial system, which includes chewing ability and oral health.

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Zinc deficiency with reduced mastication impairs spatial memory in young adult mice

Cited by 10 publications

References 24 publications

Effects of Quercetin and Resveratrol on Zinc Chloride- and Sodium Metavanadate-Induced Passive Avoidance Memory Retention Deficits in Male Mice

Effects of Quercetin and Resveratrol on Zinc Chloride- and Sodium Metavanadate-Induced Passive Avoidance Memory Retention Deficits in Male Mice

Analysis of Feeding Behavior Characteristics in the Cu/Zn Superoxide Dismutase 1 (SOD1) SOD1G93A Mice Model for Amyotrophic Lateral Sclerosis (ALS)

Chewing function and related parameters as a function of the degree of dementia: Is there a link between the brain and the mouth?

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