Toxic effect of light on oocyte and pre-implantation embryo: a systematic review

Khodavirdilou, Rasa; Pournaghi, Marjaneh; Oghbaei, Hajar; Rezaei, Yeganeh Rastgar; Javid, Farzin; Khodavirdilou, Lida; Shakibfar, Farah; Latifi, Zeinab; Hakimi, Parvin; Nouri, Mohammad; Fattahi, Amir; Dittrich, Ralf

doi:10.1007/s00204-021-03139-4

Cited by 8 publications

(4 citation statements)

References 36 publications

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“…The harmful effects of light depend on the wavelength, intensity, and duration of exposure [ 23 ]. To effectively reduce these dependencies, we used the lowest energy/longest wavelength, the lowest intensity, and the shortest exposure time.…”

Section: Discussionmentioning

confidence: 99%

“…These observations indicate that the damaging effect of light is wavelength-dependent; thus, it is reasonable to assume that the application of filters may reduce the harmful effect of environmental factors in IVF laboratories [ 17 , 21 , 22 ]. Two recent reviews [ 23 , 24 ] demonstrate the importance of reducing these harmful environmental factors. Due to the lack of consensus on the effects of light on embryos, we aimed to analyze how light protection (LP) during IVF or ICSI reduces toxic molecular effects of light on embryonic development.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Benefits of Decreased Photo-Oxidative Stress on Human Embryo Development

Gödöny,

Herczeg,

Gyenesei

et al. 2024

Med Princ Pract

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Objective: Early embryonic development is characterized by rapid cell division and gene activation, making the embryo extremely sensitive to environmental influences. Light exposure can affect embryonic development through a direct toxic effect on the embryo via the generation of reactive oxygen species (ROS). In a previous study we demonstrated the positive effect of improved light-protected embryo culture conditions implemented in our laboratory. This study aimed to investigate the changes in human embryo development under light protection during the conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Materials and Methods: We tested the potential beneficial effect of light filters to reduce the risk of toxic effects of light. IVF outcomes were compared between two experimental conditions, light protection with red light filters versus no light protection as a control. Results: Blastocyst development rate in IVF was significantly higher in the light-protected group than in the group treated under conventional conditions (46.6 vs. 26.7%). In the case of ICSI, we obtained a similar result (44.5 vs. 31.6%). The rate of cryopreservation with at least one embryo was higher in the light-protected phase (32.8%) than in the conventionally manipulated phase (26.8%). The abortion rate was also significantly lower during the light-protected period in IVF, resulting in a higher live birth rate. Conclusions: The implementation of light protection to reduce the embryotoxic wavelengths of light in IVF centers may improve the blastocyst development rate and embryo quality while maintaining embryo safety.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical Benefits of Decreased Photo-Oxidative Stress on Human Embryo Development

Gödöny,

Herczeg,

Gyenesei

et al. 2024

Med Princ Pract

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“…Both procedures offer hope to couples struggling with infertility. More specifically, the ART setting involves exposure to a range of stimuli, including superovulation ( 22 ), cryopreservation ( 23 , 24 ), exposure to various types of lights ( 25 ), fluctuations in pH and temperature ( 26 , 27 ), changes in oxygen tension ( 28 ), culture media that contain specific substances such as Fe2+ and Cu2+ ( 29 ), and gamete or embryo manipulation. All these ART interventions act during gamete-imprinted gene reprogramming and embryonic gene demethylation ( 30 ).…”

Section: Epigenetic Modification and Art-induced Cardiovascular Dysfu...mentioning

confidence: 99%

Cardiovascular health of offspring conceived by assisted reproduction technology: a comprehensive review

Li,

Liu,

Huang

et al. 2024

Front. Cardiovasc. Med.

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Recently, the use of assisted reproductive technology (ART) has rapidly increased. As a result, an increasing number of people are concerned about the safety of offspring produced through ART. Moreover, emerging evidence suggests an increased risk of cardiovascular disease (CVD) in offspring conceived using ART. In this review, we discuss the epigenetic mechanisms involved in altered DNA methylation, histone modification, and microRNA expression, as well as imprinting disorders. We also summarize studies on cardiovascular changes and other risk factors for cardiovascular disease, such as adverse intrauterine environments, perinatal complications, and altered metabolism following assisted reproductive technology (ART). Finally, we emphasize the epigenetic mechanisms underlying the increased risk of CVD in offspring conceived through ART, which could contribute to the early diagnosis and prevention of CVD in the ART population.

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“…In some cases, embryos are graded daily exposing embryos to light more frequently. A number of previous studies have investigated the impact of light on the developing embryo [11][12][13][14][15][16][17][18]. Light has several parameters that will affect embryos.…”

Section: Introductionmentioning

confidence: 99%

The effect of discrete wavelengths of visible light on the developing murine embryo

Campugan

Lim

Chow

et al. 2022

J Assist Reprod Genet

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Purpose A current focus of the IVF field is non-invasive imaging of the embryo to quantify developmental potential. Such approaches use varying wavelengths to gain maximum biological information. The impact of irradiating the developing embryo with discrete wavelengths of light is not fully understood. Here, we assess the impact of a range of wavelengths on the developing embryo. Methods Murine preimplantation embryos were exposed daily to wavelengths within the blue, green, yellow, and red spectral bands and compared to an unexposed control group. Development to blastocyst, DNA damage, and cell number/allocation to blastocyst cell lineages were assessed. For the longer wavelengths (yellow and red), pregnancy/fetal outcomes and the abundance of intracellular lipid were investigated. Results Significantly fewer embryos developed to the blastocyst stage when exposed to the yellow wavelength. Elevated DNA damage was observed within embryos exposed to blue, green, or red wavelengths. There was no effect on blastocyst cell number/lineage allocation for all wavelengths except red, where there was a significant decrease in total cell number. Pregnancy rate was significantly reduced when embryos were irradiated with the red wavelength. Weight at weaning was significantly higher when embryos were exposed to yellow or red wavelengths. Lipid abundance was significantly elevated following exposure to the yellow wavelength. Conclusion Our results demonstrate that the impact of light is wavelength-specific, with longer wavelengths also impacting the embryo. We also show that effects are energy-dependent. This data shows that damage is multifaceted and developmental rate alone may not fully reflect the impact of light exposure.

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Toxic effect of light on oocyte and pre-implantation embryo: a systematic review

Cited by 8 publications

References 36 publications

Clinical Benefits of Decreased Photo-Oxidative Stress on Human Embryo Development

Clinical Benefits of Decreased Photo-Oxidative Stress on Human Embryo Development

Cardiovascular health of offspring conceived by assisted reproduction technology: a comprehensive review

The effect of discrete wavelengths of visible light on the developing murine embryo

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