Toxic Effects Induced in Rabbits by Extracellular Products and Sonicates of Group A Streptococci

Dialyzable Form of an Extracellular Streptococcal Toxin Causing Histopathologic and Biochemical Changes in Rabbits

“…5) and the liver (Fig. The histopathological picture resembled those described earlier in these studies (5,8) with (the exception that calcification of the necrotic areas was rarely seen. The histopathological picture resembled those described earlier in these studies (5,8) with (the exception that calcification of the necrotic areas was rarely seen.…”

“…The tissue changes caused by these substances were quite similar to those caused by the G-150 excluded material in our earlier studies (5,8). It is possible that the trichloroacetic acid treatment and the alcohol precipitation cleaved a large molecule, yielding a small fraction which retained its toxicity.…”

“…Group A streptococci are known to produce a wide variety of toxic compounds (1)(2)(3)(4)(5)(6)(7)(8).…”

Streptococcal Rheumatic Carditis.

“…Localization of the cell wall components was also found to occur in the reticuloendothelial system, as expected for a particulate substance (50,131,188). Besides cardiac injury, hepatic lesions also appeared within 12 h of ijection ofthe sonicates (63,245).…”

Skin, Liver, and Corneal Lesions Produced by Injections of High Infectious Titer and UV-Irradiated Preparations of Herpes Simplex Virus in Rabbits and Guinea Pigs

“…However, this procedure did destroy two important biologic activities of the virus; namely, a fatal tonic convulsion and a capacity to induce multinucleate giant cells. The latter-type reaction has recently been observed also in the livers of rabbits after intravenous injections of extracellular proteins (exotoxins) ob-tained from cultures of Type A hemolytic streptococci ( 10,11). I t is interesting to note that the lesionproducing activities which were UV-resistant were limited to only a few tissues in vivo and that these were the tissues which are most sensitive to the effects of an active infection with the virus.…”