Toxic Effects of Anatase Titanium Dioxide Nanoparticles on Spermatogenesis and Testicles in Male Mice

Song, Guanling; Lin, Lin; Liu, Longlong; Wang, Kui; Ding, Yaobin; Niu, Qiang; Mu, Lati; Wang, Haixia; Hui, Shen; Guo, Shuxia

doi:10.15244/pjoes/70807

Cited by 25 publications

(17 citation statements)

References 8 publications

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“…Moreover, effects on semen parameters were also reported: normal sperm counts decreased from 88% (control) to 68% after 21 days of exposure [ 56 ]. Song and collaborators [ 57 ] examined the testes and sperm quality in male mice after an oral 5–10 nm TiO 2 NP exposure to of 0, 10, 50 and 100 mg/kg BW for 28 days. TiO 2 NPs exposure caused sperm malformations, a sperm cell micronucleus rate and levels of markers indicating cell damage in the testes, a further reduction in the germ cell number and spherospermia, interstitial glands, malalignment and vacuolization in spermatogenic cells at the two highest dose levels (50 and 100 mg/kg BW).…”

Section: Discussionmentioning

confidence: 99%

In Vitro Effects of Titanium Dioxide Nanoparticles (TiO2NPs) on Cadmium Chloride (CdCl2) Genotoxicity in Human Sperm Cells

et al. 2020

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The environmental release of titanium dioxide nanoparticles (TiO2NPs) associated with their intensive use has been reported to have a genotoxic effect on male fertility. TiO2NP is able to bind and transport environmental pollutants, such as cadmium (Cd), modifying their availability and/or toxicity. The aim of this work is to assess the in vitro effect of TiO2NPs and cadmium interaction in human sperm cells. Semen parameters, apoptotic cells, sperm DNA fragmentation, genomic stability and oxidative stress were investigated after sperm incubation in cadmium alone and in combination with TiO2NPs at different times (15, 30, 45 and 90 min). Our results showed that cadmium reduced sperm DNA integrity, and increased sperm DNA fragmentation and oxidative stress. The genotoxicity induced by TiO2NPs-cadmium co-exposure was lower compared to single cadmium exposure, suggesting an interaction of the substances to modulate their reactivity. The Quantitative Structure-Activity Relationship (QSAR) computational method showed that the interaction between TiO2NPs and cadmium leads to the formation of a sandwich-like structure, with cadmium in the middle, which results in the inhibition of its genotoxicity by TiO2NPs in human sperm cells.

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Section: Discussionmentioning

confidence: 99%

In Vitro Effects of Titanium Dioxide Nanoparticles (TiO2NPs) on Cadmium Chloride (CdCl2) Genotoxicity in Human Sperm Cells

et al. 2020

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“…Group 3 (NTiO 2 ): was administered first by normal saline (0.2 ml) for 7 days and then simultaneously with NTiO 2 (50mg/kg) for 35 days (Song et al ., 2017).…”

Section: Methodsmentioning

confidence: 99%

“…The NTiO 2 (Sigma-Aldrich Co.) was diluted by mili-Q water (Song et al ., 2017). A dynamic light scattering approach of Zetasizer-Nano-ZSP (Malvern, UK) was used to analyze the mean particle size distribution, polydispersity index (PDI) and zeta potential.…”

Section: Methodsmentioning

confidence: 99%

Protective effects of Curcumin on testicular toxicity induced by titanium dioxide nanoparticles in mice

Karimi

Khorsandi

Nejaddehbashi

2019

JBRA Assisted Reproduction

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Objective:In this study, we investigated the preventing effects of Curcumin (Cur) against titanium dioxide nanoparticle (NTiO2)-induced mouse testicular damage.Methods:We assessed NTiO2-intoxicated mice received 50mg/kg of NTiO2 for 35 days. The Cur + NTiO2 group was pretreated with Cur (200 mg/kg) for 7 days prior to administering NTiO2. Sperm parameters, testosterone concentration, histological criteria, morphometric parameters and Johnsen's scoring.Results:NTiO2 significantly reduced testicular weight, testosterone concentration, morphometric parameters, Johnsen's scoring and sperm quality (p<0.01), as well as a significant increase in histological criteria. Pretreatment with Cur reduced testicular weight, ameliorated morphometric parameters, increased Johnsen's scoring, elevated testosterone levels, and increased histological criteria such as vacuolization, detachment, and sloughing of germ cells into the seminiferous tubules. Cur also improved sperm parameters including sperm count, motility, and percentage of abnormality.Conclusion:Cur was found to have a potent protective effect against spermatogenesis defects induced by nanoparticles in mice.

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“…The intragastrical administration of TiO 2 NPs at doses of 10, 50 and 100 mg/kg BW induced reproductive toxicity in male mice. Results revealed that TiO 2 NPs exposure led to increased sperm malformation and decreased germ cell number [ 117 ]. The crossing ability of TiO 2 NPs through the BTB enables them to reach and accumulate in the testes [ 92 ].…”

Section: Adverse Effects Of Nps On the Reproductive Systemmentioning

confidence: 99%

Perspectives of Nanoparticles in Male Infertility: Evidence for Induced Abnormalities in Sperm Production

Iftikhar

Noureen

Uzair

et al. 2021

IJERPH

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Advancement in the field of nanotechnology has prompted the need to elucidate the deleterious effects of nanoparticles (NPs) on reproductive health. Many studies have reported on the health safety issues related to NPs by investigating their exposure routes, deposition and toxic effects on different primary and secondary organs but few studies have focused on NPs’ deposition in reproductive organs. Noteworthy, even fewer studies have dealt with the toxic effects of NPs on reproductive indices and sperm parameters (such as sperm number, motility and morphology) by evaluating, for instance, the histopathology of seminiferous tubules and testosterone levels. To date, the research suggests that NPs can easily cross the blood testes barrier and, after accumulation in the testis, induce adverse effects on spermatogenesis. This review aims to summarize the available literature on the risks induced by NPs on the male reproductive system.

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Toxic Effects of Anatase Titanium Dioxide Nanoparticles on Spermatogenesis and Testicles in Male Mice

Cited by 25 publications

References 8 publications

In Vitro Effects of Titanium Dioxide Nanoparticles (TiO2NPs) on Cadmium Chloride (CdCl2) Genotoxicity in Human Sperm Cells

In Vitro Effects of Titanium Dioxide Nanoparticles (TiO2NPs) on Cadmium Chloride (CdCl2) Genotoxicity in Human Sperm Cells

Protective effects of Curcumin on testicular toxicity induced by titanium dioxide nanoparticles in mice

Perspectives of Nanoparticles in Male Infertility: Evidence for Induced Abnormalities in Sperm Production

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