Toxic Effects of Arsenic (III) on Some Hematopoietic and Central Nervous System Variables in Rats and Guinea Pigs

Kannan, G. M.; Tripathi, Neelima; Dube, S. N.; Gupta, Manju Lata; Flora, Swaran J.S.

doi:10.1081/clt-100108508

Cited by 97 publications

(44 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Accumulation of high arsenic residues in tissues of arsenic-treated goats may be due to repeated doses. Different concentrations of arsenic in different tissues indicate different distributions (10). The highest arsenic residue in the kidneys of arsenictreated goats is consistent with earlier findings (11).…”

Section: Discussionsupporting

confidence: 81%

Effects of spirulina in arsenic poisoning in the Black Bengal goat

Ghosh¹,

Awal²,

Khan³

et al. 2014

Turk J Vet Anim Sci

View full text Add to dashboard Cite

the uplift of the CAP margins started (Yildirim et al. 2011;Cosentino et al. 2012;Schildgen et al. 2012). Here we describe the type section of the Tuğlu Formation, a sequence exceptionally rich in fossils. The section has been sampled for micropalaeontological (ostracods, foraminifera, pollen, Characeae), palaeontological (molluscs, small mammals, fish remains), environmental magnetism, and stable carbon and oxygen isotope analyses (on ostracods and bulk sediment samples) as well as strontium isotope analyses (on ostracods and foraminifera) and major elements composition of the sediments. Through a highly multidisciplinary approach, we document the Abstract: The Çankırı Basin, located in the northern part of the Central Anatolian Plateau, is a large Tertiary basin where thick Miocene to Quaternary continental sediments overlay the Cretaceous-Tertiary units. This investigation focuses on the Tuğlu Formation, an Upper Miocene succession mainly composed of dark grey silty and organic rich clays. The type section of Tuğlu has been sampled for an array of multidisciplinary analyses. The palaeontological proxies included ostracod, foraminifer, nannoplankton, pollen, molluscs, charophytes, small mammal assemblages, fish, and crab remains. The abiotic parameters studied were: palaeomagnetism and environmental magnetism, stable carbon and oxygen isotope ratios (on ostracods and bulk sediment samples), strontium isotope ratios (on ostracods and foraminifera), and major elemental composition of the sediments. All analysed proxies point to a continental setting characterised by permanent water bodies affected by strong salinity oscillations. A shallow saline lake developed in a permanent freshwater lake. Barren layers, potentially linked to a short subaerial exposure, mark the end of the saline lake and the transition to a fluvial environment. Geochemical analysis confirms aridity-humidity oscillations as recorded by the micropalaeontological proxies. Analysis of small mammal assemblages refined the chronology of the Tuğlu Formation, with the onset of the deposition at the base of the mammal zone MN9 (around 11 Ma) and continuous deposition until the MN11 zone (around 8 Ma). The stable oxygen isotope records from the Tuğlu section point to Miocene δ 18 O water values consistent with subdued topography where no prominent mountain belts were yet developed at the northern plateau margin. If correct, this suggests that at least until the end of the deposition of the Tuğlu Formation, the Çankırı Basin did not yet experience rain shadow conditions, and the regional surface uplift of the area most likely occurred after 8 Ma.

show abstract

Section: Discussionsupporting

confidence: 81%

Effects of spirulina in arsenic poisoning in the Black Bengal goat

Ghosh¹,

Awal²,

Khan³

et al. 2014

Turk J Vet Anim Sci

View full text Add to dashboard Cite

show abstract

“…4,5) 1 Present address: Tsuchiura Health Center of Ibaraki Prefecture, 2-7-46 Simotakatsu, Tsuchiura 300-0812, Japan * To whom correspondence should be addressed: Ibaraki Pre- There have been reports of effects on brain monoamine metabolism in mice after exposure to arsenic trioxide and effects on the central nervous system in rats and guinea pigs after exposure to sodium arsenite. 6,7) However, since there had been virtually no investigations of the biological effects of DPAA prior to this poisoning case, sufficient knowledge of the toxicity has not yet been obtained. Recently, the role of reactive oxygen species in various diseases has been noted.…”

Section: Introductionmentioning

confidence: 99%

Toxicity and Oxidative Stress Induced by Organic Arsenical Diphenylarsinic Acid and Inorganic Arsenicals and Their Effects on Spatial Learning Ability in Mice

Ozone

Ueno

Ishizaki

et al. 2010

JOURNAL OF HEALTH SCIENCE

View full text Add to dashboard Cite

In the present study, we investigated the oxidative stress induced by arsenical compounds in mice. Catalase (CAT) activity in the liver was decreased significantly when an organic arsenical compound, diphenylarsinic acid (DPAA), was administered to mice for 7 and 28 consecutive days. Reduced glutathione (GSH) was decreased significantly in the blood of the mice treated for 7 days with another organic arsenical, phenylmethyl arsonic acid (PMAA), and an inorganic arsenical, Na 2 HAsO 4 , as well as DPAA. GSH was also decreased significantly in the brain of the mice treated for 28 days with DPAA. Arsenic concentrations in the brain of the mice administered DPAA for 7 or 28 days were 1.6-3.0 times higher than those in the livers of these mice. The levels were about 3.0-14 times higher than those in the brains of mice administered inorganic arsenicals, suggesting that organic arsenicals tended to be more highly accumulated in the brain than inorganic arsenicals. The Morris water maze test supported these results, i.e., the latency time of the mice administered DPAA was significantly longer than that of the mice administered Na 2 HAsO 4 or NaAsO 2 , as well as that of controls without arsenical. These results showed that DPAA decreased GSH in the blood, liver and brain, and that DPAA was more easily transferred to the brain. It was suggested that spatial learning ability was depressed by the accumulation of DPAA in the brain.

show abstract

“…In vivo and in vitro studies of inorganic arsenic exposure have shown that inorganic arsenic can bind to animal and human hemoglobin (Hb) (5-7) and can change cell shape, morphology, heme metabolism, and Hb levels (8)(9)(10). Acute exposure to arsenite has been shown to cause anemia, leukopenia, and thrombocytopenia, secondary to bone marrow depression (3).…”

Section: Introductionmentioning

confidence: 99%

Gender-Specific Protective Effect of Hemoglobin on Arsenic-Induced Skin Lesions

Breton¹,

Houseman

Kile

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Chronic arsenic poisoning remains a public health crisis in Bangladesh. As arsenic has been shown to bind to human hemoglobin (Hb), hematologic mechanisms may play a role in the pathway through which arsenic exerts its toxicity. Two separate studies, a case-control and a cohort, were conducted to investigate the role of Hb in the development of arsenic-induced skin lesions. In the first, conditional logistic regression was used to investigate the effect of Hb on skin lesions among 900 case-control pairs from Pabna, Bangladesh, in which individuals were matched on gender, age, and location. In the second, mixed linear regression models were used to examine the association between toenail arsenic, urinary arsenic, and Hb within a cohort of 184 individuals from 50 families in the same region who did not have arsenic-induced skin lesions. Hb was significantly associated with skin lesions but this association was gender specific. In males, a 40% reduction in the odds of skin lesions occurred for every 1 g/dL increase in Hb (odds ratio, 0.60; 95% confidence interval, 0.49-0.73). No effect was observed for females (odds ratio, 1.16; 95% confidence interval, 0.92-1.46). In the cohort of 184 individuals, no associations between toenail arsenic or urinary arsenic species and Hb levels were observed. Low Hb levels may exacerbate the detrimental health effects of chronic arsenic poisoning. Whereas providing clean water remains the optimal solution to Bangladesh's problem of arsenic poisoning, improving nutrition and reducing iron-deficiency anemia may ameliorate negative health effects, such as skin lesions in individuals who have been exposed.

show abstract

Toxic Effects of Arsenic (III) on Some Hematopoietic and Central Nervous System Variables in Rats and Guinea Pigs

Abstract: At low doses (10 and 25 ppm in drinking water), the effects of arsenic on hematopoietic indices and whole-brain neurotransmitter concentrations were more prominent in guinea pigs than in rats with some variability in the dose response.

Cited by 97 publications

References 40 publications

Effects of spirulina in arsenic poisoning in the Black Bengal goat

Effects of spirulina in arsenic poisoning in the Black Bengal goat

Toxicity and Oxidative Stress Induced by Organic Arsenical Diphenylarsinic Acid and Inorganic Arsenicals and Their Effects on Spatial Learning Ability in Mice

Gender-Specific Protective Effect of Hemoglobin on Arsenic-Induced Skin Lesions

Contact Info

Product

Resources

About