Toxic effects of carbendazim at low dose levels in male rats

Veerappan, Muthuviveganandavel; Pandurangan, Muthuraman; Muthu, S.; Srikumar, Kotteazeth

doi:10.2131/jts.33.25

Cited by 47 publications

(33 citation statements)

References 28 publications

(20 reference statements)

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“…This investigation is in tune with the findings of Muthuviveganandavel et al (2008;2011a,b), Zari andAl-Attar (2011), andDikic et al (2012). Min and Kang (2008) reported increased ALT and AST activities in fish hepatocytes treated with benomyl, a carbendazim metabolite.…”

Section: Discussionsupporting

confidence: 92%

“…An increase in cholesterol level is a sign of liver damage (Igdedioh and Akinylene 1996). More pronounced than in the present study, carbendazim caused a significant increase in level of cholesterol in rats (Muthuviveganandavel et al 2008;Zari and Al-Attar 2011). Similar to our findings, Selmanoglu et al (2001) observed increased levels of creatinine, cholesterol, and albumin in male rats treated with carbendazim.…”

Section: Discussioncontrasting

confidence: 57%

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Sub-chronic exposure to carbendazim induces biochemical and hematological alterations in male goats

Prashantkumar¹,

Saini

Rampal

et al. 2013

Toxicological & Environmental Chemistry

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The present investigation reports the effect of repeated (90 days) administration of carbendazim on the biochemical and hematological parameters in male goats. Carbendazim administered orally at a daily dose of 50 mg kg À1 body weight for 90 consecutive days resulted in increased plasma concentration of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), gamma-glutamyl transferase (GGT), creatinine and albumin, while alkaline phosphatase (ALP) and glucose levels were decreased. Decrease in total leukocyte (TLC) and neutrophil count and increase in lymphocyte count was observed in the treatment group. The findings of the present investigation indicate that sub-chronic exposure to carbendazim in male goats causes hepatic and slight kidney dysfunctions.

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 57%

Sub-chronic exposure to carbendazim induces biochemical and hematological alterations in male goats

Prashantkumar¹,

Saini

Rampal

et al. 2013

Toxicological & Environmental Chemistry

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“…Similarly, [40] reported that thiophanate-methyl fungicide caused an increase in blood urea nitrogen (at 75, 200, and 1200 ppm) and creatinine levels (at 1200 ppm) in rats. This significant rise in creatinine levels was observed in the serum of the male Swiss albino mice after their 4th week of exposure to thimet [21]. The increase in creatinine might be due to impaired kidney function caused by the fungicide.…”

Section: Resultsmentioning

confidence: 82%

Haematological and Biochemical Effects of Metalaxyl Fungicide on Albino Mice

Al-Amoudi¹

2012

AJB

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Metalaxyl is a benzenoid fungicide used to control fungal diseases. The aim of this work is to investigate the effect of metalaxyl on haematological and biochemical parameters in male albino mice. In this study, animals were divided into two groups. The animals in the first group (20 mice) were given metalaxyl orally through a stomach tube at a dosage of 1/10 of the LD50 (which was equivalent to 130 mg/kg body weight) at a rate of three times per week for 4 continuous weeks. The second group was treated as a control in which the animals (20 mice) were given water orally. Treating mice with metalaxyl for 2 and 4 weeks induced a significant decrease in the RBC count (5.2±0.24), haemoglobin content (11.5±2.3) and the number of blood platelets (543±15.3). In contrast, metalaxyl treatment induced a significant increase in the WBC count (5.8±0.4). Serum triglyceride and cholesterol levels also increased while total protein and albumin levels decreased in the treated animals. Additionally, metalaxyl treatment resulted in a significant increase in the levels of transaminases, ALT and AST enzymes. The data also revealed a significant increase in serum creatinine in response to metalaxyl toxicity, which might be due to impaired kidney function resulting from fungicide exposure. It was concluded that these metalaxyl effects could be attributed to fungicide-induced oxidative stress, which in turn leads to signs of toxicity. This result was confirmed by other authors who obtained similar results by observing the effects of some fungicides. The premise of this study was that fungicides must be examined for their possible adverse effects on animals and humans before their application to agricultural fields.

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“…In addition, oxidative damage in RBC may results from the presence of polyunsaturated fatty acid, heme iron and oxygen 36 . Moreover, Muthuviveganandavel et al (2008) found that red blood cells count significantly decreased in rats treated with 5 and 25 mM Carbendazim, a carbamate pesticide 37 . Such results are consistent with ours.…”

Section: Hematological and Immunological Toxicity Of Carbosulfanmentioning

confidence: 99%