2008
DOI: 10.1038/jp.2008.151
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Toxic effects of different meconium fractions on lung function: new therapeutic strategies for meconium aspiration syndrome?

Abstract: To review and summarize experimental data examining the effects of different fractions of meconium, and to test the effect of albumin on meconium aspiration both as prophylactic and rescue treatment. Newborn piglets 2 to 5 days of age were made hypoxic and then instilled meconium or fractions of meconium intratracheally. Meconium-added albumin and albumin instilled after meconium were also tested. Lung function and inflammatory cytokines were measured. Both the lipid-and water-soluble fractions induce inflamma… Show more

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Cited by 3 publications
(2 citation statements)
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References 19 publications
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“…76 Rescue therapy with intratracheal albumin also improves lung function by binding and blocking active substances like free fatty acids and bile acids in meconium. 77 A protease inhibitor cocktail prevents cell detachment induced by meconium, suggesting a possible role of fetal pancreatic digestive enzymes in the treatment of MAS. 78 Liquid ventilation with perfluorocarbons has been found beneficial in improving survival in animal models of MAS, offering research potential for its use in humans.…”
Section: Future Therapymentioning
confidence: 99%
“…76 Rescue therapy with intratracheal albumin also improves lung function by binding and blocking active substances like free fatty acids and bile acids in meconium. 77 A protease inhibitor cocktail prevents cell detachment induced by meconium, suggesting a possible role of fetal pancreatic digestive enzymes in the treatment of MAS. 78 Liquid ventilation with perfluorocarbons has been found beneficial in improving survival in animal models of MAS, offering research potential for its use in humans.…”
Section: Future Therapymentioning
confidence: 99%
“…The administration of the cyclooxygenase-2 (COX-2) inhibitor parecoxib in meconium-treated rabbits attenuates histopathologic damage and meconium-induced acute lung injury with significant improvement in respiratory functions 93 . Rescue therapy with intratracheal albumin has demonstrated improvement in lung function by binding and blocking active substances such as free fatty acids and bile acids in meconium 94 . A protease inhibitor cocktail has shown promise in preventing cell detachment induced by meconium, suggesting a potential role for foetal pancreatic digestive enzymes in MAS treatment 95 .…”
Section: Future Therapymentioning
confidence: 99%