Toxic effects of magnetic nanoparticles on normal cells and organs

Jiang, Ziyu; Shan, Kuizhong; Song, Jie; Liu, Jingbing; Rajendran, Suresh; Pugazhendhi, Arivalagan; Jacob, Joe Antony; Chen, Baoan

doi:10.1016/j.lfs.2019.01.056

Cited by 111 publications

(58 citation statements)

References 61 publications

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“…Further analyses are required at different time rates, in order to catch the exact moment of penetration and to determine the type of uptake (active, by endocytosis, or passive, by diffusion). Based on experimental setups (exposure time, concentration), in vitro analyses with different or same types of cell, showed how they react differently to the same type of NPs [93]. That being so, using silica gold core-shell NPs conjugated with folic acid, Majidi et al [94] were able to quantitatively determine the intracellular uptake of gold, by A375 cell lines, through inductively coupled plasma method.…”

Section: Nanoparticle Uptake By Hacat and A375 Cellsmentioning

confidence: 99%

Green Synthesis of Ag-MnO2 Nanoparticles using Chelidonium majus and Vinca minor Extracts and Their In Vitro Cytotoxicity

et al. 2020

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Medicinal plants are often used as reducing agents to prepare metal nanoparticles through green-synthesis due to natural compounds and their potential as chemotherapeutic drugs. Thus, three types of eco-friendly Ag-MnO2 nanoparticles (Ag-MnO2NPs) were synthesized using C. majus (CmNPs), V. minor (VmNPs), and a 1:1 mixture of the two extracts (MNPs). These NPs were characterized using S/TEM, EDX, XRD, and FTIR methods, and their biological activity was assessed in vitro on normal keratinocytes (HaCaT) and skin melanoma cells (A375). All synthesized NPs had manganese oxide in the middle, and silver oxide and plant extract on the exterior. The NPs had different forms (polygonal, oval, and spherical), uniformly distributed, with crystalline structures and different sizes (9.3 nm for MNPs; 10 nm for VmNPs, and 32.4 nm for CmNPs). The best results were obtained with VmNPs, which reduced the viability of A375 cells up 38.8% and had a moderate cytotoxic effect on HaCaT (46.4%) at concentrations above 500 µg/mL. At the same concentrations, CmNPs had a rather proliferative effect, whereas MNPs negatively affected both cell lines. For the first time, this paper proved the synergistic action of the combined C. majus and V. minor extracts to form small and uniformly distributed Ag-MnO2NPs with high potential for selective treatments.

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Section: Nanoparticle Uptake By Hacat and A375 Cellsmentioning

confidence: 99%

Green Synthesis of Ag-MnO2 Nanoparticles using Chelidonium majus and Vinca minor Extracts and Their In Vitro Cytotoxicity

et al. 2020

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“…Since in literature there are several findings of harm nanoparticles that damage circulatory, digestive, endocrine, immune, integumentary, nervous, reproductive, respiratory and urinary systems [45], it is a priority to analyze the cytotoxicity of nanoparticles and the kind of harm they can cause. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) is a colorimetric technique that evaluates the metabolic activity of cells, specifically the activity of oxidoreductases enzymes found in the mitochondria.…”

Section: Cytotoxicity Testmentioning

confidence: 99%

Magnetite Nanoparticles Coated with PEG 3350-Tween 80: In Vitro Characterization Using Primary Cell Cultures

et al. 2020

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Some medical applications of magnetic nanoparticles require direct contact with healthy tissues and blood. If nanoparticles are not designed properly, they can cause several problems, such as cytotoxicity or hemolysis. A strategy for improvement the biological proprieties of magnetic nanoparticles is their functionalization with biocompatible polymers and nonionic surfactants. In this study we compared bare magnetite nanoparticles against magnetite nanoparticles coated with a combination of polyethylene glycol 3350 (PEG 3350) and polysorbate 80 (Tween 80). Physical characteristics of nanoparticles were evaluated. A primary culture of sheep adipose mesenchymal stem cells was developed to measure nanoparticle cytotoxicity. A sample of erythrocytes from a healthy donor was used for the hemolysis assay. Results showed the successful obtention of magnetite nanoparticles coated with PEG 3350-Tween 80, with a spherical shape, average size of 119.2 nm and a zeta potential of +5.61 mV. Interaction with mesenchymal stem cells showed a non-cytotoxic propriety at doses lower than 1000 µg/mL. Interaction with erythrocytes showed a non-hemolytic propriety at doses lower than 100 µg/mL. In vitro information obtained from this work concludes that the use of magnetite nanoparticles coated with PEG 3350-Tween 80 is safe for a biological system at low doses.

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“…Discussion on biological issues related to the biocompatibility, toxicity, etc. are outside the scope of this short review and can be found elsewhere [106][107][108][109][110][111]. While the present review offers a brief introduction to the topic, interested readers can find comprehensive reviews published recently [112][113][114][115][116][117].…”

Section: Discussionmentioning

confidence: 99%

Synthesis, Properties and Applications of Magnetic Nanoparticles and Nanowires—A Brief Introduction

Katz

2019

Magnetochemistry

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Magnetic nanoparticles and magnetic nano-species of complex topology (e.g., nanorods, nanowires, nanotubes, etc.) are overviewed briefly in the paper, mostly giving attention to the synthetic details and particle composition (e.g., core-shell structures made of different materials). Some aspects related to applications of magnetic nano-species are briefly discussed. While not being a comprehensive review, the paper offers a large collection of references, particularly useful for newcomers in the research area.

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Toxic effects of magnetic nanoparticles on normal cells and organs

Cited by 111 publications

References 61 publications

Green Synthesis of Ag-MnO2 Nanoparticles using Chelidonium majus and Vinca minor Extracts and Their In Vitro Cytotoxicity

Green Synthesis of Ag-MnO2 Nanoparticles using Chelidonium majus and Vinca minor Extracts and Their In Vitro Cytotoxicity

Magnetite Nanoparticles Coated with PEG 3350-Tween 80: In Vitro Characterization Using Primary Cell Cultures

Synthesis, Properties and Applications of Magnetic Nanoparticles and Nanowires—A Brief Introduction

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