Toxic epidermal necrolysis and Stevens-Johnson syndrome in South Africa: a 3-year prospective study

Kannenberg, Susanna M H; Jordaan, H.F.; Koegelenberg, C F N; Groote-Bidlingmaier, Florian von; Visser, Willem I.

doi:10.1093/qjmed/hcs078

Cited by 31 publications

(28 citation statements)

References 31 publications

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“…the Severity-of-Illness Score for Toxic Epidermal Necrolysis (SCORTEN), which was recently validated at our institution. [12] Our data suggest that SCCOR-TB cutoffs of both ≥2 and ≥3 were associated with significant increments in mortality, which could potentially guide clinicians in identifying patients at a significantly increased risk of dying from TB in the ICU. We specifically aimed to identify parameters that could be readily assessed at practically all levels of medical care, and used both the prospective data set in addition to known poor prognostic factors (e.g.…”

Section: Discussionmentioning

confidence: 66%

Validation of a severity-of-illness score in patients with tuberculosis requiring intensive care unit admission

et al. 2015

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Section: Discussionmentioning

confidence: 66%

Validation of a severity-of-illness score in patients with tuberculosis requiring intensive care unit admission

et al. 2015

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“…Observed proportion of HIV-positive patients in the present study is lower than South Africa (78.67%), Togo (54.6%) and higher than France (7.3%). [28,45,46] Incidence rate of SJS is 1,000 fold higher in HIV-positive patients as compared to general population in Germany. [47] In contrast to our study, higher cases of malignancy (10.6%) than HIV infection (6.6%) were reported in EuroSCAR.…”

Section: Discussionmentioning

confidence: 99%

A systematic review of the drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Indian population

Patel¹,

Barvaliya²,

Sharma³

et al. 2013

Indian J Dermatol Venereol Leprol

130

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“…These epidermal detachments are considered life-threatening (2) and are most frequently manifested by adverse drug reaction. In addition to occurring as a reaction to drugs, these skin eruptions are also associated with underlying infectious diseases, and include the cutaneous manifestations of disseminated candidiasis (3,4), Mycoplasma pneumoniae (5), Chlamydia pneumoniae (6), cytomegalovirus infection (7) and human immunodeficiency virus (8,9). The mortality rates of these skin eruptions have been reported to range from 16 to 25% (10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics and treatment outcome of Stevens-Johnson syndrome and toxic epidermal necrolysis

Chantaphakul

Sanon

Klaewsongkram

2015

Experimental and Therapeutic Medicine

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Abstract. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are erythematous skin lesions with blister formation accompanied by mucosal involvement. These conditions are considered to be life-threatening illnesses. Understanding the clinical presentation, risk factors, treatment options and results will be advantageous for physicians in the management of patients in the future. The aim of the present study was to review and analyze the clinical manifestations, drug implications, treatment and outcome of patients with SJS and/or TEN who had been hospitalized in a tertiary care center. All hospitalized patients with SJS and/ or TEN during a 5-year period were retrospectively reviewed. The clinical severity was graded according to the score of toxic epidermal necrolysis (SCORTEN) scale. Clinical symptoms, diagnosis, possible precipitating factors, management and outcome data were collected for analysis. A total of 43 patients (mean age, 49.5 years) were hospitalized and classified into the SJS group (55.8%), SJS/TEN overlap group (20.9%) and TEN group (23.3%). The majority of the patients (90.7%) had mucocutaneous eruptions associated with oral drug administration. Allopurinol, anticonvulsants and antibiotics were the most common causative agents for the mucocutaneous eruption. Twenty-eight patients (65.1%) were treated with corticosteroids. The mortality rate was 6.9%. Comparison between the survival group and the non-survival group revealed that patient age >70 years (P=0.014) and body surface area involvement >20% (P<0.01) were the significant factors associated with mortality. The use of systemic steroids was higher in the survival group in comparison with the non-survival group (65.1 vs. 0%, respectively; P=0.014). The mucocutaneous eruptions in SJS and TEN are mostly caused by medication. With early recognition and treatment, the mortality rate in this study was lower than that in previous reports. Patient age and the area of mucocutaneous involvement were significant factors associated with mortality.

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Toxic epidermal necrolysis and Stevens-Johnson syndrome in South Africa: a 3-year prospective study

Abstract: Most patients with TEN/SJS were HIV positive and female. We validated the use of SCORTEN and identified several prognostic indicators, most significant being HIV-tuberculosis co-infection, ≥40% skin involvement and severe sepsis.

Cited by 31 publications

References 31 publications

Validation of a severity-of-illness score in patients with tuberculosis requiring intensive care unit admission

Validation of a severity-of-illness score in patients with tuberculosis requiring intensive care unit admission

A systematic review of the drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Indian population

Clinical characteristics and treatment outcome of Stevens-Johnson syndrome and toxic epidermal necrolysis

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