Toxic, physiological, histomorphological, growth performance and antiparasitic effects of copper sulphate in fish aquaculture

Tavares‐Dias, Marcos

doi:10.1016/j.aquaculture.2021.736350

Cited by 71 publications

(30 citation statements)

References 202 publications

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“…The suppression of carp growth may be due to adverse effects of praziquantel on the metabolism, such as reducing food and nutrient uptake. Similar results were observed in the other studies with fish chemotherapeutics like formalin 37 and copper sulphate 41 .…”

Section: Discussionsupporting

confidence: 91%

“…In our study, induction of SOD and CAT in the carp whole-body homogenate after exposure to praziquantel could be an adaptive response to the stress, neutralising the impact of ROS generated. Similar results were observed in the other studies with fish chemotherapeutics like formalin 49 , ivermectin 50 , copper sulphate 41 and trichlorfon 51 , 52 .…”

Section: Discussionsupporting

confidence: 89%

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Effects of praziquantel on common carp embryos and larvae

Velíšek

Zusková

Kubec

et al. 2022

Sci Rep

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This study aimed to assess the toxicity of praziquantel (anthelmintic drug) in different developmental stages of common carp (Cyprinus carpio) based on mortality, early ontogeny, growth, oxidative stress, antioxidant enzymes, histology and behaviour. Praziquantel at all tested concentrations ranging from 1 to 4 mg/L showed no significant adverse effects on mortality, the early ontogeny and behaviour locomotory (activity, moved distance and velocity) of carp after 35-day exposure. Concentrations of 3 and 4 mg/L caused significantly (P < 0.01) lower growth, total superoxide dismutase and catalase activities compared with controls. Praziquantel is safe for the early life of carp in concentrations ≤ 2 mg/L.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 89%

Effects of praziquantel on common carp embryos and larvae

Velíšek

Zusková

Kubec

et al. 2022

Sci Rep

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“…The fish haematological profile indicates their physiological and health status and, when combined with other diagnostic methods, it can be used to identify and assess conditions that cause stress, such as the presence of pathogens and/or exposure to chemical agents (Tavares‐Dias, 2021). In this study, arapaima did not show any changes in erythrogram (RBC, haemoglobin, haematocrit, MCV, MCH and MCHC), glucose and total proteins after therapeutic baths with trichlorfon and were within the amplitude of variation for the species (Araújo et al., 2009; Drumond et al., 2010; Tavares‐Dias et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…On intensive fish farms, disease management and control are difficult, mainly due to the limited availability of licensed drugs, which are low cost with proven efficacy (Alves et al., 2019). However, in addition to being safe and effective, therapeutic agents must offer low toxicity to treated fish (Tavares‐Dias, 2021). To control fish monogeneans, several therapeutic protocols have been tested, and the most recommended molecules are trichlorfon (Zhang et al., 2014), formalin (Morales‐Serna et al., 2020), mebendazole (Chagas et al., 2016), fenbendazole and praziquantel (Merella et al., 2021).…”

Section: Introductionmentioning

confidence: 99%

Trichlorfon is effective against Dawestrema cycloancistrium and does not alter the physiological parameters of arapaima (Arapaima gigas): A large Neotropical fish from the Amazon

Cruz

Jerônimo

Bentes

et al. 2021

Journal of Fish Diseases

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This study investigated the in vitro and in vivo efficacy of trichlorfon against Dawestrema cycloancistrium, as well as its physiological effects on arapaima. Naturally parasitized arapaima gill arches were exposed in vitro to 100, 250, 500 and 750 mg/L of trichlorfon and a control group (only distilled water), in triplicate. Parasites were monitored, and mortality was used to determine the median effective concentration (EC 50 ). The 750 mg/L concentration demonstrated 100% in vitro efficacy against D. cycloancistrium after 60 min, while the intermediate (500 mg/L) and the lowest (100 and 250 mg/L) tested concentrations were completely efficient after 90 and 130 min, respectively. The EC 50-1h of trichlorfon for D. cycloancistrium was deter-

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“…Cryptocaryoniasis is currently difficult to control and causes significant issues for marine aquaculture. Although some chemicals such as copper sulfate and formalin [ 24 , 25 ] show good efficacy in killing C. irritans , there are increasing concerns about environmental pollution and human and animal safety issues from high concentrations of these chemicals. Studies on the mechanism of resistance to chemicals could contribute to reducing chemical use through increased susceptibility [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Glutathione metabolism in Cryptocaryon irritans involved in defense against oxidative stress induced by zinc ions

Zhong

et al. 2022

Parasites Vectors

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Background Cryptocaryon irritans is a fatal parasite for marine teleosts and causes severe economic loss for aquaculture. Galvanized materials have shown efficacy in controlling this parasite infestation through the release of zinc ions to induce oxidative stress. Methods In this study, the resistance mechanism in C. irritans against oxidative stress induced by zinc ions was investigated. Untargeted metabolomics analysis was used to determine metabolic regulation in C. irritans in response to zinc ion treatment by the immersion of protomonts in ZnSO4 solution at a sublethal dose (20 μmol). Eight differential metabolites were selected to assess the efficacy of defense against zinc ion stimulation in protomonts of C. irritans. Furthermore, the mRNA relative levels of glutathione metabolism-associated enzymes were measured in protomonts following treatment with ZnSO4 solution at sublethal dose. Results The results showed that zinc ion exposure disrupted amino acid metabolism, carbohydrate metabolism, lipid metabolism, and nucleotide metabolism in C. irritans. Four antioxidants, namely ascorbate, S-hexyl-glutathione, syringic acid, and ubiquinone-1, were significantly increased in the Zn group (P < 0.01), while the glutathione metabolism pathway was enhanced. The encystment rate of C. irritans was significantly higher in the ascorbate and methionine treatment (P < 0.05) groups. Additionally, at 24 h post-zinc ion exposure, the relative mRNA level of glutathione reductase (GR) was increased significantly (P < 0.01). On the contrary, the relative mRNA levels of glutathione S-transferase (GT) and phospholipid-hydroperoxide glutathione peroxidase (GPx) were significantly decreased (P < 0.05), thus indicating that the generation of reduced glutathione was enhanced. Conclusions These results revealed that glutathione metabolism in C. irritans contributes to oxidative stress resistance from zinc ions, and could be a potential drug target for controlling C. irritans infection. Graphical Abstract

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Toxic, physiological, histomorphological, growth performance and antiparasitic effects of copper sulphate in fish aquaculture

Cited by 71 publications

References 202 publications

Effects of praziquantel on common carp embryos and larvae

Effects of praziquantel on common carp embryos and larvae

Trichlorfon is effective against Dawestrema cycloancistrium and does not alter the physiological parameters of arapaima (Arapaima gigas): A large Neotropical fish from the Amazon

Glutathione metabolism in Cryptocaryon irritans involved in defense against oxidative stress induced by zinc ions

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