Toxicidad pulmonar por hiperoxia

Gordo-Vidal, F.; Calvo-Herranz, E.; Abella-Álvarez, A.; Salinas-Gabiña, I.

doi:10.1016/j.medin.2009.04.007

Cited by 15 publications

(7 citation statements)

References 39 publications

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“…Interestingly, responders to this test had a hospital mortality of 14%, whereas nonresponders had a mortality of 91% (p <0.01). We evaluated the possibility that myocardial dysfunction was not fully reversible by conducting stress echocardiography in a group of 33 patients (28 septic patients) with mean age 41 years [173]. One month after hospital discharge, all the echocardiographic alterations had normalised.…”

Section: Diagnosismentioning

confidence: 99%

Sepsis-induced Cardiomyopathy

Romero-Bermejo

Ruiz-Bailén²,

Gil-Cebrian³

et al. 2011

CCR

242

178

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Myocardial dysfunction is one of the main predictors of poor outcome in septic patients, with mortality rates next to 70%. During the sepsis-induced myocardial dysfunction, both ventricles can dilate and diminish its ejection fraction, having less response to fluid resuscitation and catecholamines, but typically is assumed to be reversible within 7-10 days. In the last 30 years, It´s being subject of substantial research; however no explanation of its etiopathogenesis or effective treatment have been proved yet. The aim of this manuscript is to review on the most relevant aspects of the sepsis-induced myocardial dysfunction, discuss its clinical presentation, pathophysiology, etiopathogenesis, diagnostic tools and therapeutic strategies proposed in recent years.

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Section: Diagnosismentioning

confidence: 99%

Sepsis-induced Cardiomyopathy

Romero-Bermejo

Ruiz-Bailén²,

Gil-Cebrian³

et al. 2011

CCR

242

178

View full text Add to dashboard Cite

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“…Numerous studies have also shown that oxygen radicals, generated primarily in response to hyperoxia, contribute to the development of hyperoxiainduced ALI, thus, implicating the presence of excessive reactive oxygen species (ROS) in the pathogenesis of ALI (Papaiahgari et al 2004;Cho et al 2006;Gore et al 2010). The development of future treatments will require detailed investigation of therapeutic modality effectiveness in new-born patients, including assessment of cytokine network imbalances corrections, inhibition of inflammatory cells, regulation of inflammatory factor release, and elevation of antioxidant capacity (Gordo-Vidal et al 2010).…”

mentioning

confidence: 99%

Calcitonin Gene-Related Peptide Ameliorates Hyperoxia-Induced Lung Injury in Neonatal Rats

Dang

Yang

Wang

et al. 2012

Tohoku J. Exp. Med.

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Therapies with prolonged exposure to high-concentration oxygen are common in the treatment of critical pulmonary and cardiac conditions in newborns. However, prolonged exposure to hyperoxia could result in lung damages and developmental disorders manifested as acute lung injury and bronchopulmonary dysplasia, respectively. Calcitonin gene-related peptide (CGRP) has been shown to have a broad regulatory effect on the respiratory system. In this study, we explored the protective effects of CGRP on the hyperoxia-induced lung damage. Newborn Sprague-Dawley rats were randomly divided into three groups: normoxia, hyperoxia, and hyperoxia with CGRP. Hyperoxia groups were exposed to 95% oxygen for 14 days and treated once every other day with saline or CGRP. Hyperoxia exposure reduced the survival rate to 73%, when compared with the 93% survival rate observed in the normoxia group. The survival rate was improved to 84% with CGRP treatment. Treatment with CGRP under hyperoxia significantly alleviated the hyperoxia-induced lung histomorphological changes and the increases in leukocyte counts and total protein levels in bronchoalveolar lavage fluid that reflect the pulmonary microvasular damages. CGRP treatment also restored the decreased activity of superoxide dismutase, while it decreased the increased level of malondialdehyde in the lung tissues. Importantly, CGRP treatment significantly decreased the magnitude of the hyperoxia-mediated increase in the expression levels of tumor necrosis factor-α mRNA and transforming growth factor-β 1 protein. In conclusion, the hyperoxia-induced acute lung injury is associated with both oxidative stress and inflammatory responses, and CGRP may ameliorate the hyperoxia-induced lung injury by down-regulating these processes.

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“…En la revisión integrativa se encontró una variedad de cuidados de enfermería enfocados a atender la necesidad de oxigenación, la cual está estrechamente relacionada con los procesos de respiración, ya que el aporte de oxígeno es fundamental en la homeostasis del sistema cardio-respiratorio. Pan et al (2020), implementaron una estrategia de oxigenoterapia que mejoró los resultados clínicos de los pacientes críticos (29), considerando que el oxígeno puede causar daño si se administra de forma inapropiada (35)(36). La hipoxemia es frecuente en pacientes con enfermedad por COVID-19, por lo que Perkins et al (2021), describieron recomendaciones dirigidas a enfermeros que brindan cuidado en la primera línea de atención (30).…”

Section: Discussionunclassified

Cuidados de enfermería ante la necesidad de oxigenación en adultos con enfermedad por COVID-19:

González

Hernández

Bello

et al. 2022

Investg. Enferm. Imagen Desarollo.

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Introducción: la enfermedad por COVID-19 genera el síndrome de distrés respiratorio agudo, afecta la necesidad de oxigenación y demanda cuidados de enfermería para mantener la estabilidad hemodinámica y prevenir complicaciones respiratorias. Objetivo: analizar la evidencia científica sobre los cuidados de enfermería ante la necesidad de oxigenación en adultos hospitalizados con enfermedad por COVID-19. Métodos: revisión integrativa con un universo de 518 artículos científicos de 2020 y 2021 de las bases de datos: PubMed, Ebsco, Cuiden y ScienceDirect. Se analizaron seis (n= 6) estudios que abordan: ¿cuáles son los cuidados de enfermería ante la necesidad de oxigenación en adultos con enfermedad por COVID-19? Resultados: los cuidados de enfermería incluyen estrategias de oxigenoterapia, recomendaciones sobre el cuidado en la primera línea de atención, uso de oxígeno de alto flujo, posicionamiento prono despierto temprano, y control de saturación y de signos vitales mediante un proceso de atención en enfermería. Conclusión: los cuidados de enfermería satisfacen la necesidad de oxigenación mediante intervenciones de oxigenoterapia, control de comorbilidades y prevención de riesgos hospitalarios.

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Toxicidad pulmonar por hiperoxia

Cited by 15 publications

References 39 publications

Sepsis-induced Cardiomyopathy

Sepsis-induced Cardiomyopathy

Calcitonin Gene-Related Peptide Ameliorates Hyperoxia-Induced Lung Injury in Neonatal Rats

Cuidados de enfermería ante la necesidad de oxigenación en adultos con enfermedad por COVID-19:

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