Toxicity and Beneficial Effects of Some African Plants on the Reproductive System

Toyin, Yakubu Musa; Olakunle, Ajiboye Taofeek; Adewunmi, Akanji Musbau

doi:10.1016/b978-0-12-800018-2.00015-7

Cited by 9 publications

(5 citation statements)

References 65 publications

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“…The 400 mg/kg oral dose of Group IV ethanolic extract was administered. All rats were given their respective treatments from the 8th to the 20th day of pregnancy [13,[21][22]. On the 21st day, the rats were sacrificed under light ether anesthesia.…”

Section: Pregnancy Preservation Animal Modelmentioning

confidence: 99%

Ethnopharmacological Study on Nigella Sativa Seeds Extracts: Pharmacognostical Screening, Abortifacient Potential and its Evolution Parameters

Alamoudi,

Almehmadi,

Ali

et al. 2023

Migrat. Lett.

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Current research investigates the abortifacient properties of Nigella sativa, a natural alternative to pharmaceutical abortifacients such as mifepristone. Abortion induced by mifepristone is often accompanied by distressing side effects, prompting the exploration of safer alternatives. Nigella sativa seeds were processed into coarse powder through grinding and subjected to ethanolic and aqueous extractions. Pregnant mice were administered extracts at 400 milligrams per kilogram of body weight, with a comparison group receiving 2.85 mg/kg p.o. of mifepristone. The study showed a significant decrease in fetal survival rates with nigella sativa extract treatment with the untreated control group exhibiting a 100% survival rate and the 400 mg/kg p.o. Dose groups showed rates of 26.66% for aqueous extract and 33.33% for ethanolic extract. Importantly, none of the fetuses in the mifeprin-treated group survived. The results indicate a promising 70% abortion rate with well-tolerated doses of Nigella sativa extracts, highlighting the potential for natural alternatives to mitigate the side effects associated with mifepristone administration. This research underscores the importance of exploring botanical sources for safer and more tolerable options in induced abortion.

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Section: Pregnancy Preservation Animal Modelmentioning

confidence: 99%

Ethnopharmacological Study on Nigella Sativa Seeds Extracts: Pharmacognostical Screening, Abortifacient Potential and its Evolution Parameters

Alamoudi,

Almehmadi,

Ali

et al. 2023

Migrat. Lett.

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“…Uteri which observed very well to record any implantation sites which might have undergone very early resorption (Jahnkle, 1999). the reproductive parameters were computed According to Toyin et al, (2014).…”

Section: Maternal Evaluationsmentioning

confidence: 99%

Evaluation of Maternal Toxicity in Rats Exposed to the Total Extract of the Alkaloids in the seeds of Peganum harmala L. during Pregnancy

Bettihi¹,

Mahdeb²,

Bouzidi³

2022

Turkish JAF Sci.Tech.

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Peganum harmala L. (Zygophyllaceae) known locally as harmel is a medicinal plant. In traditional medicine, its seeds have long been used for therapeutic purposes because of their richness in β-carboline alkaloids. This study aimed to evaluate the maternal and developmental toxicity during pregnancy by daily IP administration of 7.99 mg/kg/day (1/20 DL50) of total alkaloids extract in P.harmala’ seeds. The results summarized in confirmed pregnancy rates were high 90-100%, decreased locomotor activity, paralysis, and hypothermia. Maternal body weight and weight gain changes were statistically significant in all pregnant. Precisely, the relative weight of ovaries was significantly changed in all the groups treated. The ALAT and gamma GT concentrations show a significant change in the group treated for seven days. Significant changes in the total and indirect bilirubin levels were observed in all treated groups. The hormonal analysis showed a significant decrease in FSH levels in a treated group for seven days and two weeks, Progesterone levels were increased significantly in treated groups for seven and three weeks and increased significantly in a treated group for two groups, however, the levels of Estrogen were changed significantly only in the treated group for three. The results show a significant difference in total resorbed litters and the number of fetus deaths in the group treated for three weeks. The fetus weight in the group treated for two weeks was significant. The results show a significant decrease in the number of implantations and an increase in pre-and post-implantation loss rates, and there were no developed live or dead, and no resorbed fetuses in all treated dams, there were only implantation sites in both uterine horns. The total extract of the alkaloids in the seeds of P. harmala has adverse effects on maternotoxicity, embryonic development, and abortion.

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“…In northeast India, pineapple is favorite for the fruit lovers in its fresh as well as processed forms like jam, jelly, and squashes. The taxonomical classification of Ananas comosus is described in Table 12 49 .…”

Section: Pineapple (Ananas Comosus)mentioning

confidence: 99%

Taxonomical, Phytochemical, Traditional Explanation, Nutritional Values, and Biological Activities of Certain Edible Medicinal Plants of Tripura, India

Debnath

Singh

Goswami

et al. 2021

JNR

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Edible plants are used as valuable sources of food and medicine to prevent nutritional imbalance, illness, and maintenance of human health. This review covers botanical descriptions, phytochemicals studies, traditional comprehensions, dietary values, and biological activities of ten vegetable plants and eight fruit plants of Tripura, India. The book “The Flora of Tripura State” helps to choose the plant species of Tripura, India and PubMed, NCBI, Google scholar databases have been used to describe the plant species briefly. Literature reveals that all the selected edible plants contain bio-active constituents (alkaloids, phenols, flavonoids, tannins, terpenoids, glycosides, etc.) and give dynamic biological activities. All the plants have a high nutritional value. This review believes it will provide significant advances in the prevention of malnutrition and chronic diseases.

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Toxicity and Beneficial Effects of Some African Plants on the Reproductive System

Cited by 9 publications

References 65 publications

Ethnopharmacological Study on Nigella Sativa Seeds Extracts: Pharmacognostical Screening, Abortifacient Potential and its Evolution Parameters

Ethnopharmacological Study on Nigella Sativa Seeds Extracts: Pharmacognostical Screening, Abortifacient Potential and its Evolution Parameters

Evaluation of Maternal Toxicity in Rats Exposed to the Total Extract of the Alkaloids in the seeds of Peganum harmala L. during Pregnancy

Taxonomical, Phytochemical, Traditional Explanation, Nutritional Values, and Biological Activities of Certain Edible Medicinal Plants of Tripura, India

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