Toxicity and gastric tolerance of essential oils from Cymbopogon citratus, Ocimum gratissimum and Ocimum basilicum in Wistar rats

Fandohan, P.; Gnonlonfin, Benoit; Laleye, Anatóle; Gbénou, Joachim; Darboux, R.; Moudachirou, Mansourou

doi:10.1016/j.fct.2008.04.006

Cited by 100 publications

(49 citation statements)

References 11 publications

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“…The results obtained and the LD50 values represent a low toxicity of LEO and they were similar to the ones observed for other essential oils (Fandohan et al, 2008). The LEO increases the sleeping time induced by sodium pentobarbital in a dose-dependent manner, decrease ambulation without alter motor coordination performance LEO caused a significant reduction of ambulation of animals in the test of spontaneous movement after 0.5, 1 and 2 h of its administration in the doses of 25, 50 and 100 mg/kg, that corroborates with the hypothesis of the LEO reduces the CNS activity, it was reported that reduction of the ambulation of the animals is characteristic of psychopharmacological drugs (Fernández-Guasti et al, 2001).…”

Section: Discussionsupporting

confidence: 86%

Volatile constituents and behavioral change induced by Cymbopogon winterianus leaf essential oil in rodents

rbara¹,

Thais²,

Angelo³

et al. 2011

Afr. J. Biotechnol.

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Cymbopogon winterianus Jowitt ('Java citronella') is an important essential oil yielding aromatic grass cultivated in India and Brazil and its volatile essential oils extracted from its leaves are used in perfumery, cosmetics, pharmaceuticals and flavoring industries. However, there is no report on any psychopharmacological study of C. winterianus leaf essential oil (LEO) available to date. In this study, the pharmacological effects of the LEO were investigated in animal models and its phytochemical analyses. GC-MS analysis showed a mixture of monoterpenes, as citronellal (36.19%), geraniol (32.82%) and citronellol (11.37%). LEO exhibited an inhibitory effect on the locomotor activity of mice, an antinociceptive effect by increasing the reaction time in the writhing and capsaicin tests. All doses induced a significant increase in the sleeping time of animals not having modified however, the latency. The LEO did not alter the remaining time of the animals on the rota-rod apparatus. These results suggest a possible central effect.

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Section: Discussionsupporting

confidence: 86%

Volatile constituents and behavioral change induced by Cymbopogon winterianus leaf essential oil in rodents

rbara¹,

Thais²,

Angelo³

et al. 2011

Afr. J. Biotechnol.

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“…In this study, the body weight changes of mice treated with both 1.5 and 2.0ml/kg body weight test doses of E.globulus essential oil-water emulsion was not significantly different from the control (P>0.05). Both treatment and control group mice were showed overall gain in body weight with time over the period of the experiment, and this indicate positive health status of the animals or safety of the emulsion at lower doses [18,19,20,21].…”

Section: Discussionmentioning

confidence: 91%

Acute and Sub-chronic Oral Toxicity Evaluation of Eucalyptus globulus Essential Oil-Water Emulsion in Mice

Gebremickael¹,

Gebru²,

Debella³

et al. 2017

J Cytol Histol

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“…Sensitivity of A. flavus and A. ochraceous to basil EO is of particular interest since they produce potentially carcinogenic mycotoxins in grain and feed they colonize. This EO can be a good candidate for use in such products, being considered safe for human consumption when appropriately used (Fandohan et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Identification and Quantification of the Major Fungitoxic Components of the Brazilian Basil (Ocimum basilicum L.) Essential Oil

Barcelos¹,

Jham²,

Dhingra³

et al. 2013

JFR

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Hydrodistillation of Brazilian basil (Ocimum basilicum L.) yielded 0.4% of essential oil (EO), with activity against eight important postharvest deteriorating fungi. The crude EO completely inhibited the radial growth of the fungi at a concentration of 0.1%. Thirty-two components were identified in crude EO by Kováts retention index, mass spectrometry and standards. Preparative TLC-bioautography of the crude EO presented only one band with an antifungal activity greater than that of crude EO with the following chemical composition (%): 1,8-cineole (6.2), linalool (36.3), camphor (9.7), α-terpineol (3.8), methyl chavicol (9.1) and eugenol (34.9). Based on these results, these compounds were considered to be the major fungitoxic components. This is the first study in the literature that presents data obtained simultaneously on the activity of crude basil EO against eight important post-harvest deteriorating fungi, its unequivocal chemical identification and quantification (area %).

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Toxicity and gastric tolerance of essential oils from Cymbopogon citratus, Ocimum gratissimum and Ocimum basilicum in Wistar rats

Cited by 100 publications

References 11 publications

Volatile constituents and behavioral change induced by Cymbopogon winterianus leaf essential oil in rodents

Volatile constituents and behavioral change induced by Cymbopogon winterianus leaf essential oil in rodents

Acute and Sub-chronic Oral Toxicity Evaluation of Eucalyptus globulus Essential Oil-Water Emulsion in Mice

Identification and Quantification of the Major Fungitoxic Components of the Brazilian Basil (Ocimum basilicum L.) Essential Oil

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