Toxicity and photosynthetic inhibition of metal-organic framework MOF-199 to pea seedlings

Guan, Xin; Li, Qun; Maimaiti, Tusunniyaze; Lan, Suke; Ouyang, Peng; Ouyang, Bowei; Wu, Xian; Yang, Shengrong

doi:10.1016/j.jhazmat.2020.124521

Cited by 46 publications

(25 citation statements)

References 59 publications

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“…A comprehensive assessment of potential environmental and health risks associated with the release of ZIFs into the environment during their life cycle (including their manufacture, use, and disposal) is required before and after they enter the market. ZIFs have been reported to cause significant physiological defects in different model organisms (e.g., zebrafish) . However, knowledge about the persistence, recovery, and molecular mechanisms of ZIF toxicity remains scarce.…”

Section: Introductionmentioning

confidence: 99%

“…Performing toxicological assessments of ZIFs before their implementation in various applications is important. Cu-based MOFs have been shown to inhibit the photosynthesis of pea seedlings . Embryos and adult zebrafish were sensitive to the presence of Cu-MOF materials, and the toxicity was largely restricted to copper release from the material structure into solution .…”

Section: Introductionmentioning

confidence: 99%

“…ZIFs have been reported to cause significant physiological defects in different model organisms (e.g., zebrafish). 10 However, knowledge about the persistence, recovery, and molecular mechanisms of ZIF toxicity remains scarce.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Cu-based MOFs have been shown to inhibit the photosynthesis of pea seedlings. 10 Embryos and adult zebrafish were sensitive to the presence of Cu-MOF materials, and the toxicity was largely restricted to copper release from the material structure into solution. 11 Iron(III) polycarboxylate structure-based MOFs were found to accumulate in acidic cells and then slowly decompose, reaching 10−15% decomposition over 24 h, 12 although the toxicity of the degraded products remains unclear.…”

Section: ■ Introductionmentioning

confidence: 99%

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Persistence and Recovery of ZIF-8 and ZIF-67 Phytotoxicity

Zhang

2021

Environ. Sci. Technol.

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Zeolitic imidazolate frameworks (ZIFs) have been developed quickly and have attracted considerable attention for use in the detection and removal of various pollutants. Understanding the environmental risks of ZIFs is a prerequisite to their safe application by industry and new chemical registration by governments; however, the persistence and recovery of toxicity induced by ZIFs remain largely unclear. This study finds that typical ZIFs (e.g., ZIF-8 and ZIF-67) at a concentration of 0.01−1 mg/L induce significant algal growth inhibition, plasmolysis, membrane permeability, chloroplast damage, and chlorophyll biosynthesis, and the above alterations are recoverable. Unexpectedly, a persistent decrease in reactive oxygen species (ROS) is observed due to the quenching of hydroxyl free radicals. The adverse effects of ZIF-8 are weak and easily alleviated compared with those of ZIF-67. ZIF-8 is internalized mainly by caveolae-mediated endocytosis, while ZIF-67 is internalized mainly by clathrin-mediated endocytosis. Omics studies reveal that the downregulation of mRNA associated with oxidative phosphorylation and the inhibition of chlorophyll and adenosine triphosphate (ATP) synthesis in mitochondria are related to the persistence of phytotoxicity. These findings highlight the phenomena and mechanisms of the persistence and recovery of phytotoxicity, indicating the need to reconsider the environmental risk assessments of ZIFs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

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Persistence and Recovery of ZIF-8 and ZIF-67 Phytotoxicity

Zhang

2021

Environ. Sci. Technol.

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“…This concentration was considered for further toxicity studies. Some MOF usually released Cu in the environment (Guan et al, 2021), resulting in Cu ion accumulation in organisms and the possible promotion of oxidative stress. Excess of ROS cause death (Vaccaro et al, 2020) and other adverse effects, such as growth and development (Palozza et al, 2011).…”

Section: Structural Characterization Of Cu/ls Mofmentioning

confidence: 99%

Facile synthesis of Cu/Ls MOF for laccase-like oxidative decomposition of phenols and identification of toxicity effects for C. elegans

H¹,

Guo²,

Fu³

et al. 2021

Preprint

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Certain compounds in chemical products adsorb heavy metals co-occurring in surface waters and thereby modulate their toxicity for invertebrates. Sodium N-lauroylsarcosinate salt (Ls) is widely used as a medium additive in detergents and can chelated with certain metal ions. In this study, we constructed metal-organic framework by the co-assembly of Ls and Cu (Cu/Ls MOF), which has laccase like activity. The morphology of Cu/Ls appeared spherical or ellipsoidal with a diameter in the range of 50–500 nm. Cu/Ls MOF followed the typical Michaelis-Menten model and showed laccase-like activity and oxidizes phenol-containing substrates, such as phenol, 4-iodophenol, and 2,4,5-trichlorophenol. To understand the toxicity of Cu/Ls exposure, the Caenorhabditis elegans (C. elegans) was exposed to various concentrations of Cu/Ls, and the impact on physiological level was determined. High dose of Cu/Ls increased the levels of reactive oxygen species (ROS), decreased the exercise activity of the C. elegans and inhibited the growth of their larvae. Cu/Ls had strong binding interaction and the ability of Cu/Ls to oxidize pollutants may be a form of self-regulation by nature. The biological toxicity of Cu/Ls is low under high concentration conditions, and the dose of MOF that may be formed by the discharge of daily washing is less harmful to the environment.

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