Toxicity evaluation following pulmonary exposure to an as-manufactured dispersed boron nitride nanotube (BNNT) material in vivo

Xing, Xin; Barger, Mark; Roach, Katherine A.; Bowers, Lauren; Stefaniak, Aleksandr B.; Kodali, Vamsi; Glassford, Eric; Dunn, Kevin L.; Wolfarth, Michael G.; Friend, Sherri; Leonard, Stephen S.; Kashon, Michael L.; Porter, Dale W.; Erdely, Aaron; Roberts, Jenny R.

doi:10.1016/j.impact.2020.100235

Cited by 20 publications

(49 citation statements)

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“…[139] The latest BNNT report (June 2020) from the National Institute for Occupational Safety and Health (NIOSH) is a BNNT study in vitro and noted that higher doses of BNNT in pulmonary exposure can cause damage. [140] This biocompatibility is still being extensively studied and has not been conclusive due to the varying models. For example, unlike the NIOSH work, Ciofani and co-workers from Instituto Italiano di Tecnologia, Italy have been studying the toxicity of BNNTs and concluded that the BNNTs do not accumulate in the body.…”

Section: Toxicitymentioning

confidence: 99%

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Structure, Properties and Applications of Two‐Dimensional Hexagonal Boron Nitride

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Hexagonal boron nitride (h-BN) has emerged as a strong candidate for twodimensional (2D) material owing to its exciting optoelectrical properties combined with mechanical robustness, thermal stability, and chemical inertness. Super-thin h-BN layers have gained significant attention from the scientific community for many applications, including nanoelectronics, photonics, biomedical, anti-corrosion, and catalysis, among others. This review provides a systematic elaboration of the structural, electrical, mechanical, optical, and thermal properties of h-BN followed by a comprehensive account of stateof-the-art synthesis strategies for 2D h-BN, including chemical exfoliation, chemical, and physical vapor deposition, and other methods that have been successfully developed in recent years. It further elaborates a wide variety of processing routes developed for doping, substitution, functionalization, and combination with other materials to form heterostructures. Based on the extraordinary properties and thermal-mechanical-chemical stability of 2D h-BN, various potential applications of these structures are described.The ORCID identification number(s) for the author(s) of this article can be found under

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Section: Toxicitymentioning

confidence: 99%

Section: Structure and Properties Of H‐bnmentioning

confidence: 99%

Structure, Properties and Applications of Two‐Dimensional Hexagonal Boron Nitride

et al. 2021

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“…The fatal dose of orally ingested boric acid for an adult is near the range 15-20g and for infant it is 5-6 g which is very close to the permissive level. Long-term consumption of boron-contaminated food and water by humans may cause the development of serious syndromes, persistent vomiting, diarrhea, and other cardiovascular ailments [28]. Therefore, it is significant to monitor and control the boron content in water, especially in the case of drinking water.…”

Section: Toxicity Of Boronmentioning

confidence: 99%

An updated review on boron removal from water through adsorption processes

et al. 2021

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Boron is an essential micronutrient that has raised much interest, given the narrow balance between its necessity and toxicity. Both natural and anthropogenic emissions of boron into water sources can eventually deteriorate water quality and endanger the ecosystem. In this review, we first present a general outline of the importance of boron, boron chemistry in water, boron contamination, and its consequences followed by the recent progress in boron removal methods based on adsorption. The adsorbents for deboronation can generally be classified based on the functional groups present; chelating groups, metal oxides, and layered double hydroxides. To comprehensively address these adsorption methods, a detailed discussion on the reaction mechanism of each system is done followed by a summary of the progress in the field during the past 5 years. Finally, some characterization techniques used in deboronation studies and suggestions for future research and applications together with possible improvements to the existing systems are presented. Graphical abstract

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“…In vitro models employing both acute and sub-chronic exposure conditions have been developed and used to predict in vivo toxicological responses ( Cho et al, 2013 ; Manke et al, 2014 ; Wang et al, 2014 ). Based on comparable exposure doses, time courses, target cell types, and relevant biological endpoints, consistent results have been obtained from comparable experiments with in vitro vs. in vivo models using similar ENMs (e.g., based on physicochemical properties) such as carbon nanotubes ( Mercer et al, 2011 ; Mishra et al, 2012 ; Sargent et al, 2014 ; Siegrist et al, 2014 ; Snyder-Talkington et al, 2015 , 2019 ), metal oxide nanoparticles ( Ma et al, 2015 ; Davidson et al, 2016 ), boron nitride nanotubes ( Kodali et al, 2017 ; Xin et al, 2020 ), and end-life cycle (incinerated) nanoclay enabled thermoplastics ( Stueckle et al, 2018 ; Wagner et al, 2018 ). These results, mainly observed from CDC/NIOSH research projects on the ENMs of agency interest listed in Table 1 , support the implementation of in vitro models as a rapid and economical tool to screen and predict the potential in vivo toxicological responses to ENMs for reducing, refining, and replacing animal usage.…”

Section: Agency Needs For Enm Testingmentioning

confidence: 53%

U.S. Federal Agency interests and key considerations for new approach methodologies for nanomaterials

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of such State, or (B) which affects trade, traffic, transportation, or commerce described in clause (A).(4) The terms "distribute in commerce" and "distribution in commerce"' when used to describe an action taken with respect to a chemical substance or mixture or article containing a substance or mixture mean to sell, or the sale of, the substance, mixture, or article in commerce ; to introduce or deliver for introduction into commerce, or the introduction or delivery for intr-oduction into commerce of, the substance, mixture, or article; or to hold, or the holding of, the substance, mixture, or article after its introduction into commerce.(5) The term "environment" includes water, air, and land and the i interrelationship which exists among and between water, air, and land and all living things.(6) The term "health and safety study" means any study of any effect of a chemical substance or mixture on health or the environment or on both, including underlying data and epidemiological studies, studies of occupational exposure to a chemical substance or mixture, toxicological, clinical, and ecological studies of a chemical substance or mixture, and any test performed pursuant to this Act.(7) The term "manufacture" means to import into the customs territory of the United States (as defined in general headnote 2 of the Tariff Schedules of the United States), produce, or manufacture. 19 USC 1202.(8) The term "mixture" means any combination of two or more chemical substances if the combination does not occur in nature and is not, in whole or in part, the result of a chemical reaction; except that such term does include any combination which occurs, in whole or in part, as a result of a chemical reaction if none of the chemical substances comprising the combination is a new chemical substance and if tlie combination could have been manufactured for commercial purposes without a chemical reaction at the time the chemical substances comprising the combination were combined.(9) The term "new chemical substance" means any chemical substance which is not included in the chemical substance list compiled and published under section 8 (b).Post, p. 2027. (10) The term "process" means the preparation of a chemical substance or mixture, after its manufacture, for distribution in commerce-(A) in the same form or physical state as, or in a different form or physical state from, that in which it was received by the person so preparing such substance or mixture, or (B) as part of an article containing the chemical substance .;;:;>• or mixture. (11) The term "processor" means any person who processes a chemical substance or mixture.(12) The term "standards for the development of test data" means a prescription of-(A) the-(i) health and environmental effects, and (ii) information relating to toxicity, persistence, and other characteristics which affect health and the environment, for which test data for a chemical substance or mixture are to be developed and any analysis that is to be performed on such data, and -(B) to the extent necess...

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Toxicity evaluation following pulmonary exposure to an as-manufactured dispersed boron nitride nanotube (BNNT) material in vivo

Cited by 20 publications

References 71 publications

Structure, Properties and Applications of Two‐Dimensional Hexagonal Boron Nitride

Structure, Properties and Applications of Two‐Dimensional Hexagonal Boron Nitride

An updated review on boron removal from water through adsorption processes

U.S. Federal Agency interests and key considerations for new approach methodologies for nanomaterials

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