Toxicity From Unintentional Pediatric Ingestion of a Performance-Enhancing Drug: A Case Report With Review of Clenbuterol Toxicity and Treatment

Bonney, Caitlin; Hatten, Benjamin W.; Wang, George S.

doi:10.1016/j.jemermed.2019.06.016

Cited by 7 publications

(3 citation statements)

References 15 publications

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“…In the case of a child weighing 15 kg, consuming 100 g of sausage containing a clenbuterol concentration of 471 pg g −1 could exceed the recommended acceptable daily intake of 0–0.004 μg kg −1 of body weight. Therefore, it could be toxic 38 …”

Section: Resultsmentioning

confidence: 99%

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Detection of clenbuterol residues in beef sausages and its enantiomeric analysis using UHPLC–MS/MS: A risk of unintentional doping in sport field

Velasco-Bejarano

Velasco-Carrillo

Camacho-Frias

et al. 2022

Drug Testing and Analysis

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Clenbuterol (Clb) can be present in Mexico often but not all over the world in animal tissues and organs, therefore, potentially is derived from animal sources as well. The aims of this study were to develop and validate a method for detecting traces of clenbuterol in beef sausages. A calibration curve showed linearity in the range of 20-500 pg ml À1 . The limit of detection (LOD) and lower limit of quantification (LLOQ) were 5 and 10 pg g À1 , respectively. The analyte recovery was from 95.70% to 100.40% with an intraday relative standard deviation (RSD%) of 0.99%-2.10% and an interday RSD% of 0.54%-2.34%, R 2 = 0.9998. The methodology developed was applied successfully in 15 samples of beef sausage, and 73.3% of the samples tested contained racemic clenbuterol in concentrations between 30 and 471 pg g À1 .The UHPLC-MS/MS method developed combines high sensitivity with good selectivity and short chromatographic run time. Additionally, the enantiomeric analysis of clenbuterol performed in beef sausages showed a 59% for R-(À)-Clb and 41% for S-(+)-Clb. The presence of clenbuterol in beef sausages could represent a risk of unintentional doping in sport field, because the clenbuterol is a banned substance included in the World Anti-Doping Agency's (WADA) list of prohibited substances.

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Section: Resultsmentioning

confidence: 99%

“…Therefore, it could be toxic. 38 To the best of our knowledge, no international regulations describe the potential risk of consuming clenbuterol in sausages. It is important to verify that all animals and animal products destined for human consumption are free of these substances.…”

Section: Detection Of Clenbuterol In Beef Sausage Samplesmentioning

confidence: 99%

Detection of clenbuterol residues in beef sausages and its enantiomeric analysis using UHPLC–MS/MS: A risk of unintentional doping in sport field

Velasco-Bejarano

Velasco-Carrillo

Camacho-Frias

et al. 2022

Drug Testing and Analysis

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“…Clenbuterol is an oral β2-agonist with anabolic and lipolytic effects, used off-licence as a ‘fat-busting’ drug 2. Adverse effects in adults are well documented, but there are limited data on effects in children or adolescents 3 4. Serious adverse effects include arrhythmia, hypotension and myocardial infarction, even in the absence of concomitant cardiovascular risk factors 5.…”

Section: Introductionmentioning

confidence: 99%

Clenbuterol: a new toxic substance in paediatrics

et al. 2020

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A 13-year-old girl presented to the emergency department with acute onset of chest pain, nausea and tremor. The patient denied drug ingestion, and urine toxicology was negative. ECG demonstrated sinus tachycardia, prolonged QTc (541 ms) and ST depression. Laboratory testing demonstrated metabolic acidosis, hypokalaemia, hypophosphataemia and hyperglycaemia. She was commenced on continuous cardiac monitoring and treated with intravenous fluids and electrolyte replacement. Presenting features and laboratory abnormalities resolved within 48 hours. The National Poisons Information Service and Clinical Biochemistry were integral to her management, advising the clinical team on the likeliest aetiology. Five weeks after discharge, urine toxicology, using mass spectrometry, identified clenbuterol. Clenbuterol is an oral β2-agonist with anabolic and lipolytic effects that is misused as a performance and image enhancing drug. Clinicians must be aware of the increasing availability of these drugs and their potential for causing harm in children and adolescents.

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Adverse events of clenbuterol among athletes: a systematic review of case reports and case series

et al. 2023

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Toxicity From Unintentional Pediatric Ingestion of a Performance-Enhancing Drug: A Case Report With Review of Clenbuterol Toxicity and Treatment

Cited by 7 publications

References 15 publications

Detection of clenbuterol residues in beef sausages and its enantiomeric analysis using UHPLC–MS/MS: A risk of unintentional doping in sport field

Detection of clenbuterol residues in beef sausages and its enantiomeric analysis using UHPLC–MS/MS: A risk of unintentional doping in sport field

Clenbuterol: a new toxic substance in paediatrics

Adverse events of clenbuterol among athletes: a systematic review of case reports and case series

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