Toxicity in Goats Exposed to Arsenic in the Region Lagunera, Northern Mexico

Ortega-Morales, Natalia B; Cueto-Wong, José Antonio; Barrientos-Juárez, Eutiquio; Garcı́a-Vargas, Gonzalo G.; Salinas-González, Homero; Garcia, Alain Buendía; Morán-Martínez, Javier

doi:10.3390/vetsci7020059

Cited by 11 publications

(4 citation statements)

References 16 publications

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“…Exposed groups received arsenic in drinking water 1 mg/L of arsenic (As 2 O 3 ; Sigma Aldrich, St. Luis Missouri, USA) equivalent to 1 ppm, for an interrupted period of 16 weeks, and the control groups received non-As-contaminated water to drink ad libitum. The arsenic dose used in this study was a midpoint based on the highest concentrations of As in drinking water recorded around the world (500–2040 µg/L) 109 – 111 . Furthermore, this dose of arsenic trioxide has been one of the lowest doses recorded, where reproductive abnormalities are shown in males 38 .…”

Section: Methodsmentioning

confidence: 99%

Transgenerational effects in DNA methylation, genotoxicity and reproductive phenotype by chronic arsenic exposure

Nava-Rivera

Betancourt-Martínez

Lozoya-Martínez

et al. 2021

Sci Rep

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An emerging concern is the influences of early life exposure to environmental toxicants on offspring characteristics in later life. Since recent evidence suggests a transgenerational transference of aberrant phenotypes from exposed-parents to non-exposed offspring related to adult-onset diseases including reproductive phenotype. The transgenerational potential of arsenic a well know genotoxic and epigenetic modifier agent has not been assessed in mammals until now. In this experimental study, we evaluated the transgenerational effects of arsenic in a rat model with chronic exposure to arsenic. Rats chronically exposed to arsenic in drinking water (1 mg As2O3/mL) (F0) were mated to produce the arsenic lineage (F1, F2, and F3). The arsenic toxic effects on were evaluated over the four generations by analyzing the DNA methylation percentage, genotoxicity in WBC and physical and reproductive parameters, including sperm quality parameters and histopathological evaluation of the gonads. Chronic exposure to arsenic caused genotoxic damage (F0–F3) different methylation patterns, alterations in physical and reproductive parameters, aberrant morphology in the ovaries (F0 and F1) and testicles (F1–F3), and a decrease in the quality of sperm (F0–F3, except F2). Parental chronic arsenic exposure causes transgenerational genotoxicity and changes in global DNA methylation which might be associated with reproductive defects in rats. Combined with recent studies reveal that disturbances in the early life of an individual can affect the health of later generations.

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Section: Methodsmentioning

confidence: 99%

Transgenerational effects in DNA methylation, genotoxicity and reproductive phenotype by chronic arsenic exposure

Nava-Rivera

Betancourt-Martínez

Lozoya-Martínez

et al. 2021

Sci Rep

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“…This investigation should aim to assess the contribution of As intake from these sources, as well as its potential effects on the population. Furthermore, farm animals exposed to As through contaminated drinking water and feed materials could suffer adverse health effects 73 , highlighting the need for further investigation in this area.…”

Section: Discussionmentioning

confidence: 99%

Association of obesity, diabetes, and hypertension with arsenic in drinking water in the Comarca Lagunera province (north-central Mexico)

Sánchez-Rodríguez¹,

Castillo-Maldonado²,

Pedroza-Escobar³

et al. 2023

Sci Rep

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Chronic endemic regional hydroarsenicism (CERHA) is a global issue that affects over 200 million people exposed to arsenic (As) in drinking water. This includes 1.75 million individuals residing in La Comarca Lagunera, a region in north-central Mexico. Arsenic levels in this region typically exceeds the WHO guideline of 10 µg L−1. Biochemical alterations related to the human As metabolism may increase the risk of overweight and obesity (O&O), type 2 diabetes (T2D), and hypertension (AHT). In our study, we investigated the role of As in drinking water as a risk factor for these metabolic diseases. We focused on populations with historically moderate (San Pedro) and low (Lerdo) drinking water As levels and people with no historical evidence of As water contamination. The exposure assessment to As was based on measurements of the drinking water (medians 67.2, 21.0, 4.3 µg L−1) and urinary As concentrations in women (9.4, 5.3, 0.8 µg L−1) and men (18.1, 4.8, 1.0 µg L−1). A significant correlation between As in drinking water and urine evidenced the As exposure in the population (R2 = 0.72). Adjusted odds ratios with 95% confidence intervals evidenced higher chances of being diagnosed with T2D (1.7, 1.2–2.0) and AHT (1.8, 1.7–1.9) in individuals living in San Pedro than those in Lerdo. Still, there was no significant association with obesity. Individuals living in CERHA towns were found to have a higher risk of obesity (1.3–1.9), T2D (1.5 to 3.3), and AHT (1.4 to 2.4) compared to those residing in non-CERHA towns. Finally, obesity is more probable in women [inverse of OR and 95%CI 0.4 (0.2–0.7)] compared to men, while men is more likely to be diagnosed with T2D [OR = 2.0 (1.4–2.3)] and AHT [OR = 2.0 (1.5–2.3)] than women, independently of the municipality.

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“…This semi-arid area is one of the hotspots of groundwater arsenic contamination in the world, and elevated levels of arsenic have been reported in this area. Our previous study reported high levels of drinking water arsenic in this region, ranging from 20.6 to 709.3 µg/L [ 31 ]. Therefore, the residents in this area were considered as potentially exposed to high concentrations of arsenic from their drinking water.…”

Section: Methodsmentioning

confidence: 99%

Comparative Biomonitoring of Arsenic Exposure in Mothers and Their Neonates in Comarca Lagunera, Mexico

Salcedo

Roh

Rivera

et al. 2022

IJERPH

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Multiple comorbidities related to arsenic exposure through drinking water continue to be public problems worldwide, principally in chronically exposed populations, such as those in the Comarca Lagunera (CL), Mexico. In addition, this relationship could be exacerbated by an early life exposure through the placenta and later through breast milk. This study conducted a comparative analysis of arsenic levels in multiple biological samples from pregnant women and their neonates in the CL and the comparison region, Saltillo. Total arsenic levels in placenta, breast milk, blood, and urine were measured in pregnant women and their neonates from rural areas of seven municipalities of the CL using atomic absorption spectrophotometry with hydride generation methodology. The average concentrations of tAs in drinking water were 47.7 µg/L and 0.05 µg/L in the exposed and non-exposed areas, respectively. Mean levels of tAs were 7.80 µg/kg, 77.04 µg/g-Cr, and 4.30 µg/L in placenta, blood, urine, and breast milk, respectively, in mothers, and 107.92 µg/g-Cr in neonates in the exposed group, which were significantly higher than those in the non-exposed area. High levels of urinary arsenic in neonates were maintained 4 days after birth, demonstrating an early arsenic exposure route through the placenta and breast milk. In addition, our study suggested that breastfeeding may reduce arsenic exposure in infants in arsenic-contaminated areas. Further studies are necessary to follow up on comorbidities later in life in neonates and to provide interventions in this region.

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Toxicity in Goats Exposed to Arsenic in the Region Lagunera, Northern Mexico

Cited by 11 publications

References 16 publications

Transgenerational effects in DNA methylation, genotoxicity and reproductive phenotype by chronic arsenic exposure

Transgenerational effects in DNA methylation, genotoxicity and reproductive phenotype by chronic arsenic exposure

Association of obesity, diabetes, and hypertension with arsenic in drinking water in the Comarca Lagunera province (north-central Mexico)

Comparative Biomonitoring of Arsenic Exposure in Mothers and Their Neonates in Comarca Lagunera, Mexico

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