Toxicity in Oil Meal, Bioassay for Toxic Factor in Trichloroethylene-extracted Soybean Oil Meal

Failure of DL-Batyl Alcohol to Prevent Aplastic Anemia in Calves.

“…The action of cobaltous chloride is of particular interest because of its damaging effect on pancreatic a-cells (9). Caren and Carbo (8) found that cobaltous chloride given intravenously causes an increase in plasma cholesterol concentration of rabbits lasting 1 or 2 weeks.…”

The Synthesis of S35-(1,2-Dichlorovinyl)-L-Cysteine1a

“…of ether to remove dibenzyl sulfide and disulfide which were present as solids or oils. The ether extracts were combined and extracted 3 times with water, the first washing being done with water containing a drop of -V NaOH. The aqueous extracts were combined with the extracted aqueous solution, adjusted to pH 5.5 with H( (pH paper) and concentrated by drawing air across the surface with slight warming.…”

S-(DICHLOROVINYL)-L-CYSTEINE: AN AGENT CAUSING FATAL APLASTIC ANEMIA IN CALVES1

“…The electric dipole moment measurements made on such complexes dissolved in dioxane and benzene have afforded evidence against such a view.2 On the other hand, the hypothesis that paramagnetic octahedral disolvated complexes are formed, although improbable in the light of the investigations by Basolo and Matoush3 on the coórdinating tendencies of the methylbenzenes, cannot be ruled out. 4 In fact the existence of a silver perchloratebenzene complex6 shows that benzene and metal atoms may bind together.…”

“…B. Willis and D. P, Mellor, This Journal, 69, 1237 (3) F. Basolo and W. R. Matoush, ibid., 75, 5663 (1953). (4) Cf. H. C. Clark and A. L. Odell, .7.…”

“…assay of TESOM. 4 The assay results are shown in Table I. The 500 and 200 mg./100 lb./day dosage levels were not tolerated by the assay calves and had to be discontinued after 5 and 7 days, respectively; however, all dosage levels tested produced the complete clinical, hematologic and postmortem picture of severe aplastic anemia of the bovine.4 We recently reported6 on fractionation studies of toxic TESOM which indicated that the aplastic anemia causing entity is associated with the protein component of the meal.…”