Toxicity of aliphatic amines: Structure-activity relationship

Greim, Helmut; Bury, Dagmar; Klimisch, H.-J.; Oeben-Negele, M.; Ziegler‐Skylakakis, Kyriakoula

doi:10.1016/s0045-6535(97)00365-2

Cited by 138 publications

(84 citation statements)

References 10 publications

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“…However, the nitrosamine impurity present in DPA is considered to be a carcinogen by the USEPA. DPA and some o f its derivatives (nitroand amino-substituted compounds and the stabilizers) have mutagenic and carcinogenic potential (Greim et al, 1998;Lachance et al, 1999). Products derived from anaerobic conversion o f DPA have more carcinogenic effects than DPA itself.…”

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confidence: 99%

Laccase‐Catalyzed Removal of Diphenylamine from Synthetic Wastewater

Saha

Taylor

Bewtra

et al. 2008

Water Environment Research

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The priority pollutant lists of both the U.S. Environmental Protection Agency (U.S. EPA) and the European Union (EU) include diphenylamine (DPA), a contaminant found in wastewater of various industries. This work demonstrates the potential of using enzymatic treatment to remove DPA from buffered synthetic wastewater. This treatment method includes oxidative polymerization of DPA using laccase from Trametes villosa, followed by removal of those polymers via adsorptive micellar flocculation (AMF) using sodium lauryl sulfate (SDS) and alum. Researchers investigated the effects of pH, laccase concentration, molecular mass, and concentration of polyethylene glycol (PEG) in continuously stirred batch reactors to achieve 95% substrate conversion in three hours. Treatment of 0.19 mM DPA was best at pH 7 and an enzyme concentration from 0.0025 to 0.0075 standard activity unit/mL. Except for PEG 400, optimum enzyme and PEG concentrations decreased with an increase in PEG molecular mass. Optimum AMF conditions were pH 3.0 to 6.5, 200 mg/L of SDS, and 150 mg/L of alum.

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confidence: 99%

Laccase‐Catalyzed Removal of Diphenylamine from Synthetic Wastewater

Saha

Taylor

Bewtra

et al. 2008

Water Environment Research

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“…Amines vapors are of particular interest since low concentrations of both aliphatic and aromatic amines have toxicological effects. [26,27] In addition, alcohols such as methyl alcohol and ethyl alcohol are volatile organic solvents that are commonly used in many workplaces, laboratories, medicine, food industry, and chemicals industry. The exposure to methyl alcohol vapor for a long time causes some diseases such as eyesight disturbance, nasal mucous membrane, conjunctiva inflammation, nerve disease, and even death.…”

Section: Introductionmentioning

confidence: 99%

Detection of some volatile organic compounds with chitosan-coated quartz crystal microbalance

Ayad

Salahuddin

Minisy

2014

Designed Monomers and Polymers

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A quartz crystal microbalance (QCM) electrode coated with Chitosan (Cs) film was used as a sensor for some volatile organic compounds (VOCs) such as aliphatic amines and alcohols. A homogeneous smooth thin films of Cs coating on the QCM electrode was prepared by drop casting method. The frequency shifts (Δf) of the QCM, due to adsorption of the VOCs under investigation, onto the Cs film were measured and were related to the analytes' concentrations. Calibration curves were obtained with linear relationships between the Δf (Hz) and the analyte concentrations (mg L −1 ). The sensor showed good sensitivity, reproducibility, and reversibility. The influence of different temperatures on the vapor adsorption, of the VOCs onto the Cs film, was studied.

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“…In addition to their industrial applications, some amines may occur as biodegradation products of proteins and amino acids, or other nitrogencontaining compounds. Besides hygienic problems due to their odorous smell, these compounds may be hazardous to human health as they are sensitizers and irritants to the skin, eyes, mucous membranes and respiratory tract, and some have even been considered as tumourinducing agents (Greim et al, 1998). Moreover, there is a growing concern that these compounds in source * Corresponding author.…”

Section: Introductionmentioning

confidence: 99%

Occurrence of selected aliphatic amines in source water of major cities in China

Zhang

Ren

Yang

2012

Journal of Environmental Sciences

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The formation of toxic nitrogenous disinfection byproducts (N-DBPs), such as nitrosamines, halonitromethanes and haloacetonitriles, from reactions between chlorine/chloramine and dissolved organic nitrogen in drinking water has caused great concern with regarding public health. This study revealed the occurrence of 17 aliphatic amines, some of which have been confirmed to be the precursors of N-DBPs, in source water across China. A sensitive method based on benzenesulfonyl chloride derivatization and liquid-liquid extraction followed by GC-MS analysis was established for the simultaneous analysis of the selected amines in aqueous samples. In total, 37 source water samples from the capital cities of 20 provinces were collected for the survey. Among the 17 amines, 14 were detected with an average frequency of detection of 36%. The most relevant amines in terms of frequency and maximum concentrations detected were dimethylamine (100%, 24.82 μg/L), methylamine (78%, 0.92 μg/L), N-methylethylamine (70%, 8.84 μg/L), propylamine (59%, 10.69 μg/L), diethylamine (54%, 3.76 μg/L), N-methylbutylamine (35%, 3.07 μg/L), N-ethylpropylamine (35%, 0.52 μg/L), and piperidine (32%, 2.35 μg/L). This is the first large scale survey of the aliphatic amines occurrence in source water in the world. The wide presence of nitrosamine precursors like dimethylamine, N-methylethylamine and diethylamine, and the precursors of haloacetonitriles and halonitromethanes like methylamine and propylamine suggests that better source water management is required to ensure the safety of drinking water.

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Toxicity of aliphatic amines: Structure-activity relationship

Cited by 138 publications

References 10 publications

Laccase‐Catalyzed Removal of Diphenylamine from Synthetic Wastewater

Laccase‐Catalyzed Removal of Diphenylamine from Synthetic Wastewater

Detection of some volatile organic compounds with chitosan-coated quartz crystal microbalance

Occurrence of selected aliphatic amines in source water of major cities in China

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