Toxicity of aqueous extract of Euphorbia tirucalli latex on catfish, Heteropneustes fossilis

Kumar, Abhishek; Prasad, M. V. R.; Mishra, Devesh; Srivastav, Sunil Kumar; Srivastav, Ajai K.

doi:10.1016/j.ecoenv.2010.08.003

Cited by 18 publications

(11 citation statements)

References 11 publications

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“…Exposure to Euphorbia tirucalli has been proposed to be a cofactor in the genesis of endemic Burkitt's lymphoma as suggested by the coincidence between this condition and human exposure to this plant in the lymphoma belt of Africa [20]. E. tirucalli is also widely used for poison fishing in tropical Africa [21] as corroborated by its strong piscicidal effects towards the catfish Heteropneustes fossilis [22]. Owing to the high amounts of triterpenes and sterols of E. tirucalli, it was also suggested that this plant might be used for rubber fractionation so that it was investigated for its diesel oil properties [23].…”

Section: Introductionmentioning

confidence: 99%

Further terpenoids from Euphorbia tirucalli

et al. 2019

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The phytochemical investigation of Euphorbia tirucalli L. (Euphorbiaceae) yielded four new compounds, including a rare cadalene-type sesquiterpene (tirucadalenone), two tirucallane triterpenoids, euphorol L and euphorol M, with the latter being described as an epimeric mixture, and a euphane triterpene, namely, euphorol N, together with 7 known compounds. Their structures and absolute configurations were elucidated from analysis of 1D (1H, J-modulated 13 C) and 2D NMR (HSQC, HMBC and NOESY), high-resolution mass spectrometry (HRESIMS), optical rotation, and GIAO NMR shift calculation followed by CP3 analysis, along with comparison with literature reports. All these compounds were tested for cytotoxicity against K562, MCF-7 and/or and HepG2 tumor cell lines. Only tirucadalenone displayed a mild cytotoxic activity. Graphical abstractFour previously undescribed terpenoids: a cadalene (1), two tirucallanes (2 and 3a/3b), and a euphane (4) were isolated from Euphorbia tirucalli L. ACCEPTED MANUSCRIPT

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Section: Introductionmentioning

confidence: 99%

Further terpenoids from Euphorbia tirucalli

et al. 2019

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“…They observed the 96-h LC 50 value of Moringa oleifera seed extract for the freshwater, Cyprinus carpio to be high 124.0mg/L. Kumar et al, (2010) reported that the 24, 48, 72 and 96-h LC 50 values of aqueous extract of Euphorbia tirucalli latex to the fish Heteropneustes fossilis was found to be 3.450µl/L, 2.516µl/L, 1.623µl/L and 1.315 µl/L respectively. Tiwari and Singh (2003) observed the toxicity of Nerium indicum leaf extract to the fish Channa punctatus and indicate that the toxicity depends on the solvent used for extraction; the LC 50 value of diethylether, acetone, chloroform and methanol extract of N. indicum leaf extract were found to be 17.34mg/L, 40.01mg/L, 40.61 mg/L and 106.37mg/L, respectively.…”

Section: Physicochemical Characteristics Of Syntheticmentioning

confidence: 99%

Acute toxicity of synyhetic resin effluent to African Catfish, Clarias gariepinus [BURCHELL, 1822]

Dahunsi¹,

Oranusi²

2012

AJFN

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Aquatic pollution as a field has gained a lot of attention over the decades majorly because of the vital role the aquatic environment plays in the human lifecycle. Indusrial wastewaters are often generated and discharged into the environment without treatment. Toxicity of effluents from Synythetic Resin production plant were evaluated in this study. Acute toxicity (96-h LC 50 ) was evaluated using 0.23, 0.31, 0.35 and 0.39 mg/L of the effluent in a renewal bioassay procedure. Physicochemical parameters of the effluent were also evaluated, the values obtained for lead, cyanide, total suspened solid, total hadness, total dissolved solids and alkalinity were higher than the Federal Environmental Protection Agency standard specification for effluent discharge into aquatic environment and as such contributed to the effluent's toxicity. Mortality increased as the concentrations of the effluent increases and 0.355mg/L was obtained as LC 50 . The research eventually revealed that the synthetic resin effluent has a high level of toxicity to catfish. Deleterious effects such as biomagnification and other abberations may occur in man if exposed to substantial concentration of the effluent.

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“…It also shows co-carcinogenic and anti-carcinogenic activities [18]. In addition, the sap of E. tirucalli showed relevant potential larvicide against Aedes aegypti and Culex quinquefasciatus , the most common dengue vector and lymphatic filariasis vector, respectively [19] and demonstrated higher piscicidal activity as compared with other synthetic pesticides, organophosphates and pyrethroids for the fish Heteropneustes fossilis [20]. Furthermore, a very recent study demonstrated that biopolymeric fraction (BET) from plant E. tirucalli showed dose dependent anti-arthritic activity and demonstrated in vivo suppression of CD4 + and CD8 + T cells associated with inhibition of intracellular IL-2 and IFN-γ [21].…”

Section: Introductionmentioning

confidence: 99%

Preventive and Therapeutic Euphol Treatment Attenuates Experimental Colitis in Mice

et al. 2011

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BackgroundThe tetracyclic triterpene euphol is the main constituent found in the sap of Euphorbia tirucalli. This plant is widely known in Brazilian traditional medicine for its use in the treatment of several kinds of cancer, including leukaemia, prostate and breast cancers. Here, we investigated the effect of euphol on experimental models of colitis and the underlying mechanisms involved in its action.Methodology/Principal FindingsColitis was induced in mice either with dextran sulfate sodium (DSS) or with 2,4,6-trinitrobenzene sulfonic acid (TNBS), and the effect of euphol (3, 10 and 30 mg/kg) on colonic injury was assessed. Pro-inflammatory mediators and cytokines were measured by immunohistochemistry, enzyme-Linked immunoabsorbent assay (ELISA), real time-polymerase chain reaction (RT-PCR) and flow cytometry. Preventive and therapeutic oral administration of euphol attenuated both DSS- and TNBS-induced acute colitis as observed by a significant reduction of the disease activity index (DAI), histological/microscopic damage score and myeloperoxidase (MPO) activity in colonic tissue. Likewise, euphol treatment also inhibited colon tissue levels and expression of IL-1β, CXCL1/KC, MCP-1, MIP-2, TNF-α and IL-6, while reducing NOS2, VEGF and Ki67 expression in colonic tissue. This action seems to be likely associated with inhibition of activation of nuclear factor-κB (NF-κB). In addition, euphol decreased LPS-induced MCP-1, TNF-α, IL-6 and IFN-γ, but increased IL-10 secretion from bone marrow-derived macrophages in vitro. Of note, euphol, at the same schedule of treatment, markedly inhibited both selectin (P- and E-selectin) and integrin (ICAM-1, VCAM-1 and LFA-1) expression in colonic tissue.Conclusions/SignificanceTogether, these results clearly demonstrated that orally-administered euphol, both preventive or therapeutic treatment were effective in reducing the severity of colitis in two models of chemically-induced mouse colitis and suggest this plant-derived compound might be a potential molecule in the management of inflammatory bowel diseases.

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Toxicity of aqueous extract of Euphorbia tirucalli latex on catfish, Heteropneustes fossilis

Cited by 18 publications

References 11 publications

Further terpenoids from Euphorbia tirucalli

Further terpenoids from Euphorbia tirucalli

Acute toxicity of synyhetic resin effluent to African Catfish, Clarias gariepinus [BURCHELL, 1822]

Preventive and Therapeutic Euphol Treatment Attenuates Experimental Colitis in Mice

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