Toxicity of Brachuryan crabs in India

Fredrick, W. Sylvester; Ravichandran, S.; Balasubramanian, T.

doi:10.1080/02772248.2010.519452

Cited by 4 publications

(1 citation statement)

References 10 publications

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“…The Rasayana drugs are reported to act as an antioxidant, anti-inflammatory, neuroprotective, immunostimulant, and adaptogenic. 9 Crabs are the most common macrofauna in coastal areas, and are found in variety of species and even groups. Some of these crabs have poisons in the form of specific protein compounds.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Karkataka Taila, an Edible crab Rasayana, and assessment of its toxicological effects on SH-SY5Y cell line and on Drosophila melanogaster embryos

NP¹,

Baragur²,

Naik³

et al. 2022

Pharmacogn. J.

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Background: Karkataka Taila (KT) is virgin coconut oil (VCO) based Rasayana formulation that is enriched with the flesh of freshwater edible crab, Scylla serrata, used to treat Parkinson's Disease (PD) or Kampavata by local Ayurveda practitioners of Kerala state. There is no scientific study carried out on its toxicological effects so far. Objective: To understand the ayurvedic preparation method for KT and assessment of the toxicological effects of the KT and VCO on SH-SY5Y cell lines and Drosophila melanogaster embryos. Materials and methods: The SH-SY5Y cell lines treated with different concentrations of KT and VCO range from 6.25 µg/ml to 100 µg/ml and Drosophila melanogaster embryos fed with food containing different concentrations of KT and VCO, ranging from 0.005 % to 10 %. Results: KT and VCO did not show any significant cytotoxicity effect on SH-SY5Y cell lines up to a dose concentration of 25 µg. But, at 50 µg and 100 µg concentrations, KT has shown a cytotoxic effect and it was higher than the VCO. The toxicological analysis in Drosophila has shown that the survival rate of the KT treated group at concentration ranges from 0.005 % to 10 % is significantly decreased from 78.8 % to 27.7 %, compared to the control group, whereas in VCO treated group, at 0.005 % to 10 %, the survival rate has decreased from 76.2 % to 66 %, which is marginally higher than the KT treated group. Conclusion: Our findings revealed that as the concentration of Rasayana in the medium increases, there is a noticeable adverse effect on the percentage viability in SH-SY5Y cell lines and in the number of offspring in Drosophila. The effect of vehicle, VCO, at the same concentration has shown a protective effect on cell lines and flies. It can be concluded that the toxic effect has been observed only at higher concentrations of KT and at the lower concentration, the toxic effect has been minimal.

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Section: Introductionmentioning

confidence: 99%

Preparation of Karkataka Taila, an Edible crab Rasayana, and assessment of its toxicological effects on SH-SY5Y cell line and on Drosophila melanogaster embryos

NP¹,

Baragur²,

Naik³

et al. 2022

Pharmacogn. J.

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Ethnopharmacological validation of Karkataka Taila-An edible crab Rasayana in rotenone-induced in vitro and in vivo models of Parkinson's disease

Deepika,

Krishnamurthy,

Varshini

et al. 2024

Journal of Ethnopharmacology

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First occurrence of Actaeodes tomentosus (H. Milne Edwards, 1834) (Brachyura: Xanthidae: Actaeinae) in the Mediterranean Sea

Corsini-Foka

Kondylatos

2014

Medit. Mar. Sci.

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The presence of the crab Actaeodes tomentosus, native to the Indo-Pacific Ocean and the Red Sea, is documented for the first time in the Mediterranean Sea, on the basis of two specimens collected from Rhodes Island (Aegean Sea), a marine area particularly vulnerable to warm-water alien invasions. Along with the recent report of Xanthias lamarckii in similar conditions and region, the finding of another non-indigenous xanthid opens many questions regarding their occurrence in the area. Apart from the Lessepsian migration, other possible vectors of introduction are therefore examined.

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Toxicity of Brachuryan crabs in India

Cited by 4 publications

References 10 publications

Preparation of Karkataka Taila, an Edible crab Rasayana, and assessment of its toxicological effects on SH-SY5Y cell line and on Drosophila melanogaster embryos

Preparation of Karkataka Taila, an Edible crab Rasayana, and assessment of its toxicological effects on SH-SY5Y cell line and on Drosophila melanogaster embryos

Ethnopharmacological validation of Karkataka Taila-An edible crab Rasayana in rotenone-induced in vitro and in vivo models of Parkinson's disease

First occurrence of Actaeodes tomentosus (H. Milne Edwards, 1834) (Brachyura: Xanthidae: Actaeinae) in the Mediterranean Sea

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