Toxicity of copper intake: lipid profile, oxidative stress and susceptibility to renal dysfunction

Galhardi, Cristiano Machado; Diniz, Yeda S.; Faine, Luciane Aparecida; Rodrigues, Hosana Gomes; Burneiko, Regina C.; Ribas, B.; Novelli, Ethel L. B.

doi:10.1016/j.fct.2004.07.020

Cited by 137 publications

(93 citation statements)

References 40 publications

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“…1 However, if the Cu intake exceeds the range of biological tolerance, it can exert toxic side effects, including kidney damage, hemolysis, jaundice, and liver and gastrointestinal distress. 2,3 Copper nanoparticles (Cu NPs), one of the manufactured NPs, are now industrially produced and available commercially. Recently, Cu NP has shown great promise as an antibacterial material [4][5][6][7] and even been used as intrauterine contraceptive device (IUD).…”

Section: Introductionmentioning

confidence: 99%

Copper nanoparticle-induced ovarian injury, follicular atresia, apoptosis, and gene expression alterations in female rats

Yang¹,

Hu²,

Rao³

et al. 2017

IJN

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Numerous studies have reported the accumulation of copper nanoparticles (Cu NPs) in organs and the corresponding damage, although whether Cu NPs can be translocated to the ovaries and their ovarian toxicity are still unknown. In this study, three groups of female rats were injected with 3.12, 6.25, or 12.5 mg/kg Cu NPs for 14 consecutive days. The pathological changes, hormone levels, apoptosis and apoptotic proteins, oxidative stress, and gene expression characteristics in the ovaries were then investigated. The results demonstrated that the Cu NPs exhibited obvious accumulation in the rat ovaries, leading to ovarian injury, an imbalance of sex hormones, and ovarian cell apoptosis. Cu NP exposure activated caspase 3, caspase 8, caspase 9, and tBid, decreased the protein levels of Bcl-2, increased the expression levels of the proteins Bax and cytochrome c , and promoted malondialdehyde (MDA) accumulation and superoxide dismutase (SOD) reduction. Furthermore, gene microarray analysis showed that Cu NPs (12.5 mg/kg/d) caused 321 differentially expressed genes. Of these, 180 and 141 genes were upregulated and downregulated, respectively. Hsd17b1 , Hsd3b1 , Hsd3b6 , and Hsd3b were involved in steroid and hormone metabolism, whereas Mt3 and Cebpb were associated with apoptosis. Overall, these findings provide strong evidence that Cu NPs trigger both intrinsic and extrinsic apoptotic pathways and regulate key ovarian genes in oxidative stress-mediated ovarian dysfunction.

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Section: Introductionmentioning

confidence: 99%

Copper nanoparticle-induced ovarian injury, follicular atresia, apoptosis, and gene expression alterations in female rats

Yang¹,

Hu²,

Rao³

et al. 2017

IJN

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“…It is supposed that metabolism of lipid hydroperoxides in presence of redox-metals can lead to increased generation of various products like short and long chain cholesterol esters and prospholipids (Abuja & Albertini 2001). A large proportion of these products can be transported in serum by HDL that can lead to increase in HDL concentration (Galhardi et al 2004). At the same time, elevation in HDL concentration can be a consequence of beneficial effect of copper.…”

Section: Discussionmentioning

confidence: 99%

Serum lipoprotein profile and oxidative stress biomarkers in Wistar rats fed drinking water containing iron and copper

Tinkov¹,

Nikonorov²

2013

Biologia

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The aim of the research was to estimate the effect of different doses and combinations of iron and copper consumption with drinking water on lipid profile and oxidative stress biomarkers in albino Wistar rats serum. Rats were given drinking water containing 3 mg L −1 and 6 mg L −1 iron; copper 4.88 and 9.76 mg L −1 ; a mixture of 3 mg L −1 iron and 4.88 mg L −1 copper. Control group obtained pure drinking water. Total cholesterol, lipoprotein spectrum and markers of lipid and protein oxidation were analyzed. It has been seen that administration of iron in concentration of 6 mg L −1 induces lipid peroxidation and protein oxidation, while copper given in the maximal doses leads only to protein oxidation. Free radical oxidation in rats obtaining combination of iron and copper with drinking water was more expressed than in case of administration of single metals in the same doses. Consumption of maximal doses of isolated metals leads to more expressed atherogenic changes, while combination of both metals in lower doses did not affect serum lipoprotein significantly. The data obtained show that chemical interaction of iron and copper in the organism has an additive effect on some vital parameters in comparison to isolated metal administration.

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“…Compared to microcopper (17 μm), nanocopper (23.5 μm) can rapidly interact with artificial gastric acid juice and be transformed into ionic copper with ultrahigh reactivity. Moreover, metabolic alkalosis and copper accumulation in the kidneys were detected in mice that were orally exposed to nanocopper particles [148]. Although the potential risks of nanocopper particles on human health have been identified, subacute toxicity of it has not been described [149].…”

Section: Toxicity Of Copper Nanoparticlesmentioning

confidence: 99%

Nanotoxicity: Dimensional and Morphological Concerns

Wani

Hashim

Nabi

et al. 2011

Advances in Physical Chemistry

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Nanotechnology deals with the construction of new materials, devices, and different technological systems with a wide range of potential applications at the atomic and molecular level. Nanomaterials have attracted great attention for numerous applications in chemical, biological, and industrial world because of their fascinating physicochemical properties. Nanomaterials and nanodevices are being produced intentionally, unintentionally, and manufactured or engineered by different methods and released into the environment without any safety test. Nantoxicity has become the subject of concern in nanoscience and nanotechnology because of the increasing toxic effects of nanomaterials on the living organisms. Nanomaterials can move freely as compared to the largesized particles; therefore, they can be more toxic than bulky materials. This review article delineates the toxic effects of different types of nanomaterials on the living organisms through different sources, like water, air, contact with skin, and the methods of determinations of these toxic effects.

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Toxicity of copper intake: lipid profile, oxidative stress and susceptibility to renal dysfunction

Cited by 137 publications

References 40 publications

Copper nanoparticle-induced ovarian injury, follicular atresia, apoptosis, and gene expression alterations in female rats

Copper nanoparticle-induced ovarian injury, follicular atresia, apoptosis, and gene expression alterations in female rats

Serum lipoprotein profile and oxidative stress biomarkers in Wistar rats fed drinking water containing iron and copper

Nanotoxicity: Dimensional and Morphological Concerns

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