Toxicity of diuron metabolites in human cells

Mohammed, Ali Mustafa; Huovinen, Marjo; Vähäkangas, Kirsi

doi:10.1016/j.etap.2020.103409

Cited by 23 publications

(8 citation statements)

References 33 publications

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“…Dentre os herbicidas mais utilizados ao redor do mundo pode-se citar o diuron, sendo também um dos mais eficazes no que diz respeito ao controle de ervas daninhas indesejadas (LIU et al, 2018;MOHAMMED;HUOVINEN;VÄHÄKANGAS, 2020).…”

Section: O Herbicida Diuronunclassified

GESTÃO DE PESQUISA E DESENVOLVIMENTO (P&D): PROPOSIÇÃO DE UM QUADRO TEÓRICO DE ANÁLISE

Bagagi¹

2022

Desenvolvimento Tecnológico, Ciência E Inovação

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Direitos para esta edição cedidos à Atena Editora pelos autores. Open access publication by Atena Editora Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição-Não-Comercial-NãoDerivativos 4.0 Internacional (CC BY-NC-ND 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam necessariamente a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.Todos os manuscritos foram previamente submetidos à avaliação cega pelos pares, membros do Conselho Editorial desta Editora, tendo sido aprovados para a publicação com base em critérios de neutralidade e imparcialidade acadêmica.A Atena Editora é comprometida em garantir a integridade editorial em todas as etapas do processo de publicação, evitando plágio, dados ou resultados fraudulentos e impedindo que interesses financeiros comprometam os padrões éticos da publicação. Situações suspeitas de má conduta científica serão investigadas sob o mais alto padrão de rigor acadêmico e ético.

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Section: O Herbicida Diuronunclassified

GESTÃO DE PESQUISA E DESENVOLVIMENTO (P&D): PROPOSIÇÃO DE UM QUADRO TEÓRICO DE ANÁLISE

Bagagi¹

2022

Desenvolvimento Tecnológico, Ciência E Inovação

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“…This suggests that pregnant women can suffer fetotoxicity if they are exposed to DUR. Mohammed et al (2020) indicated that DUR metabolites are more toxic than the parent compound in human cells, with the mitochondria as their target. Concerning the effects of chronic exposure to herbicides and the mechanisms involved, several questions regarding ecotoxicology remain to be addressed ( Akcha et al, 2020 ).…”

Section: Environmental Occurrence and Toxicitymentioning

confidence: 99%

Emerging Strategies for the Bioremediation of the Phenylurea Herbicide Diuron

Zhang

Lin

et al. 2021

Front. Microbiol.

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Diuron (DUR) is a phenylurea herbicide widely used for the effective control of most annual and perennial weeds in farming areas. The extensive use of DUR has led to its widespread presence in soil, sediment, and aquatic environments, which poses a threat to non-target crops, animals, humans, and ecosystems. Therefore, the removal of DUR from contaminated environments has been a hot topic for researchers in recent decades. Bioremediation seldom leaves harmful intermediate metabolites and is emerging as the most effective and eco-friendly strategy for removing DUR from the environment. Microorganisms, such as bacteria, fungi, and actinomycetes, can use DUR as their sole source of carbon. Some of them have been isolated, including organisms from the bacterial genera Arthrobacter, Bacillus, Vagococcus, Burkholderia, Micrococcus, Stenotrophomonas, and Pseudomonas and fungal genera Aspergillus, Pycnoporus, Pluteus, Trametes, Neurospora, Cunninghamella, and Mortierella. A number of studies have investigated the toxicity and fate of DUR, its degradation pathways and metabolites, and DUR-degrading hydrolases and related genes. However, few reviews have focused on the microbial degradation and biochemical mechanisms of DUR. The common microbial degradation pathway for DUR is via transformation to 3,4-dichloroaniline, which is then metabolized through two different metabolic pathways: dehalogenation and hydroxylation, the products of which are further degraded via cooperative metabolism. Microbial degradation hydrolases, including PuhA, PuhB, LibA, HylA, Phh, Mhh, and LahB, provide new knowledge about the underlying pathways governing DUR metabolism. The present review summarizes the state-of-the-art knowledge regarding (1) the environmental occurrence and toxicity of DUR, (2) newly isolated and identified DUR-degrading microbes and their enzymes/genes, and (3) the bioremediation of DUR in soil and water environments. This review further updates the recent knowledge on bioremediation strategies with a focus on the metabolic pathways and molecular mechanisms involved in the bioremediation of DUR.

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“…Generally, chemical metabolism in plants typically occurs in four distinct ways, including Phase I (simple functional group changes), Phase II (conjugation with plant endogenous compounds), Phase III (transportation), and noncanonical Phase IV (other reactions) . Few DU derivatives have been currently identified in microbes, aquatic life, weed plants, animals, and human cells, such as 3,4-dichloroanilines, N -3,4-dichlorophenylurea, and N -(3,4-dichlorophenyl)- N -methylurea, which belong to the Phase I metabolites and have been proved to be a higher risk for human beings than the parent compound due to the increasing evidence of their genotoxic and teratogenic properties in animals. , The Phase II metabolic process is considered an important detoxification approach for most toxins, where lower toxic metabolites are generated by the binding with hydrophilic endogenous like sugar, amino acid, sulfate, or phosphate groups. These Phase II-based metabolites could be easily excreted from plant cells or transferred to vacuoles for isolation by transporters in the Phase III process .…”

Section: Introductionmentioning

confidence: 99%

Molecular Responses and Degradation Mechanisms of the Herbicide Diuron in Rice Crops

Wang

Zhang

Yuan

et al. 2022

J. Agric. Food Chem.

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Diuron [DU; 3-(3,4-dichlorophenyl)-1,1-dimethylurea], a widely used herbicide for weed control, arouses ecological and health risks due to its environment persistence. Our findings revealed that DU at 0.125–2.0 mg L–1 caused oxidative damage to rice. RNA-sequencing profiles disclosed a globally genetic expression landscape of rice under DU treatment. DU mediated downregulated gene encoding photosynthesis and biosynthesis of protein, fatty acid, and carbohydrate. Conversely, it induced the upregulation of numerous genes involved in xenobiotic metabolism, detoxification, and anti-oxidation. Furthermore, 15 DU metabolites produced by metabolic genes were identified, 7 of which include two Phase I-based and 5 Phase II-based derivatives, were reported for the first time. The changes of resistance-related phytohormones, like JA, ABA, and SA, in terms of their contents and molecular-regulated signaling pathways positively responded to DU stress. Our work provides a molecular-scale perspective on the response of rice to DU toxicity and clarifies the biotransformation and degradation fate of DU in rice crops.

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Toxicity of diuron metabolites in human cells

Cited by 23 publications

References 33 publications

GESTÃO DE PESQUISA E DESENVOLVIMENTO (P&D): PROPOSIÇÃO DE UM QUADRO TEÓRICO DE ANÁLISE

GESTÃO DE PESQUISA E DESENVOLVIMENTO (P&D): PROPOSIÇÃO DE UM QUADRO TEÓRICO DE ANÁLISE

Emerging Strategies for the Bioremediation of the Phenylurea Herbicide Diuron

Molecular Responses and Degradation Mechanisms of the Herbicide Diuron in Rice Crops

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