Toxicity of endodontic filling materials

Rappaport, Harold M.; Lilly, Gilbert E.; Kapsimalis, Peter

doi:10.1016/0030-4220(64)90480-3

Cited by 126 publications

(16 citation statements)

References 8 publications

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“…When Ihe results obtained in the in vitro part of the present investigation were compared with the results of the in vii'O study a good correlation was seen with regard to the direct effects of the antiseptics on the cells and tissue, This finding was at variance with the less good correlations that have been obser\'ed when in vitro test methods similar to the one presently employed have been compared with implantation tests (16,24). However, in previous implantation studies it • has not been possible to evaluate the initial tissue response to a material (23).…”

Section: Discussionsupporting

confidence: 49%

Biological evaluation of root canal antiseptics using in vitro and in vivo methods

Wennberg

1980

European J Oral Sciences

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– Five antiseptics commonly used in endodontic treatment were evaluated with regard to cytotoxicity and initial tissue irritating effect. The cytotoxicity was evaluated in a cell culture system using HeLa cells and the initial tissue irritating effect was assessed by application of the antiseptics onto an intact nonepithelialized tissue surface. The cell response was assessed by registering changes in the DNA synthesis of the cells and the tissue response was assessed by registering changes in the oxidoreductase enzyme activity of the tissue. To evaluate the ability of the cells and the tissue to overcome an induced damage, one part of the study included a recovery period before the condition of the cells and the tissue was assessed. The most severe cell and tissue reactions were caused by 5% Chloramine‐T® whereas no differences in toxicity or tissue irritating effect were found between 0.04% Jodopax®, 0.1% Bioscpt®, 0.1 % Hibitanc®, or 0.5% sodium hypochlorite. The HeLa cells showed the best recovery after having been influenced by Jodopax, Chloramine‐T or sodium hypochlorite solutions, whereas the best tissue recovery was observed in the experiments with Biosept and Hibitane.

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Section: Discussionsupporting

confidence: 49%

Biological evaluation of root canal antiseptics using in vitro and in vivo methods

Wennberg

1980

European J Oral Sciences

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“…Thus, any potentially toxic properties of endodontic sealers should be thoroughly investigated. Toxicity research has been conducted on a myriad of historical and contemporary sealers by in vivo methods such as subcutaneous connective tissue implantation in animals (11)(12)(13) or in vitro studies on cell cultures (12, 14 -16), but no completely tissue-compatible sealer is currently available.…”

mentioning

confidence: 99%

An In Vitro Evaluation of the Growth of Human Periodontal Ligament Fibroblasts after Exposure to a Methacrylate-based Endodontic Sealer

Heitman¹,

Joyce²,

McPherson³

et al. 2008

Journal of Endodontics

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“…Endodontic obturation materials may have prolonged contact with periradicular tissues and ideally should have good biocompatibility. However, most obturation materials currently in use have a certain degree of cytotoxicity (13).…”

mentioning

confidence: 99%