Toxicity of food contaminant furan on liver and kidney of growing male rats

Selmanoğlu, Güldeniz; Karacaoğlu, Elif; Kılıç, Aysun; Koçkaya, E. Arzu; Akay, M. Turan

doi:10.1002/tox.20673

Cited by 29 publications

(23 citation statements)

References 44 publications

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“…In our work in diabetic furan treated rats, there were significantly decreased activities in SOD, CAT, GST, and GPx compared with diabetic control rats. Similar to our work, Selmanoglu, Karacaoğlu, Kılıç, Koçkaya, and Akay () and Ucar and Pandır () have also shown that antioxidants’ activities were shown to change in rats fed on furan. The alterations in activities of enzymes can be due to the generation of ROS (Baş, Kalender, Pandır, & Kalender, ).…”

Section: Discussionsupporting

confidence: 89%

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Furan-induced cardiotoxicity in diabetic rats and protective role of lycopene

Saracoğlu¹,

Baş

Pandır

2018

J Food Biochem

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The objective of this current study is to search the impacts of furan and lycopene on a diabetic rat's heart. Diabetes increases prevalence with a sedentary lifestyle and obesity. Furan, a carcinogen, was detected in foods that had undergone thermal treatment. Two groups were formed, such as: the control and diabetic groups. Diabetic groups fall into four allocated groups: control, lycopene, furan, and furan + lycopene. The changes in malondialdehide levels, antioxidant enzymes’ activities, and histopathology of the heart were pointed out. We observed that the changes in both the MDA level and the antioxidant enzymes’ activities were due to diabetes. Furan‐induced increment in MDA levels, but GST, CAT, SOD, and GPx activities showed a decrease. Lycopene influenced these changes positively. In terms of the pathological studies, changes were also observed in diabetic rats. The histological damage in the diabetic furan groups was found to be very serious. Lycopene was protective against furan that caused histopathological changes. Diabetes and furan resulted into heart damages in rats and lycopene showed preventive effects. But this was not a complete protection. Practical applications Furan by product of chlorinated chemical compounds production and chemical processes including combustion, are virtually ubiquitous in the environment. Because of this, furan occur potential risk for human health. Furan is known to exist at higher levels in fatty foods, such as full‐fat milk and dairy products, meat and eggs. They can accumulate in the fatty tissues of animals and humans. Diabetes increase in the prevalence of a sedentary lifestyle and obesity. Diabetes with furan‐induced cardiotoxicity. Foods should not be heated over and over again, especially diabetic heart patients should stay away from this situation.

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Section: Discussionsupporting

confidence: 89%

“…Furan causes undesirable effects in living things (Gill et al, ). Another study showed that furan influenced the antioxidant defense system (Selmanoglu et al, ). In this study, MDA, which is the indicator of LPO, was measured and the damage was determined.…”

Section: Discussionmentioning

confidence: 99%

Furan-induced cardiotoxicity in diabetic rats and protective role of lycopene

Saracoğlu¹,

Baş

Pandır

2018

J Food Biochem

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“…Incremental MDA was determined in the liver of furan-exposed rats. Selmanoğlu et al (34) also reported enhanced MDA levels in furan toxicity in their work.…”

Section: Discussionmentioning

confidence: 85%

“…Alterations of antioxidant enzyme activities observed in this work may be due to the production of ROS. Selmanoğlu et al (34) reported that treatment of rats with furan showed changes in antioxidant enzyme activities. Connections between chemical treatment and alterations in antioxidant enzyme activities have been proven (36).…”

Section: Figure 6 (A) Liver Section Of Control Rats Cv: Central Veinmentioning

confidence: 99%

Furan-induced hepatotoxic and hematologic changes in diabetic rats: the protective role of lycopene

Baş

Pandır

Kalender

2016

Archives of Industrial Hygiene and Toxicology

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Furan forms as a result of thermal treatment of food and induces harmful effects on organisms. In our work, lycopene, furan, and a combination of the two were given to diabetic male rats for 28 days. Hematological changes, total protein and cholesterol, triglyceride, and albumin levels, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and alkaline phosphatase activities of the serum, malondialdehyde levels, glutathione peroxidase, catalase, glutathione-S-transferase, superoxide dismutase activities, DNA damage in liver tissues and hepatic histopathological alterations were compared to a control group. There were significant changes in the liver function tests, DNA damage, activities of antioxidant enzymes, and malondialdehyde levels between diabetic control and non-diabetic control groups, between diabetic control and diabetic lycopene groups, and also between diabetic furan and diabetic control groups. In diabetic lycopene and diabetic furan + lycopene treated groups we designated the preventive effects of lycopene against diabetes and furan, however, on the analysed parameters only. In spite of some pathological alterations designated in diabetic furan treated group's liver, fewer pathological alterations were observed in furan+lycopene treated groups at the end of week 4. Consequently, lycopene significantly reduced furan-and diabetes-induced toxicity in rat liver.

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“…Furthermore, the authors observed an increased mitotic activity in the subcapsular regions of the left and caudate lobe accompanied by an occasional apoptotic cell and inflammatory foci with accumulation of mononuclear cells. Selmanoglu et al (2012) treated juvenile male Wistar rats by gavage with 2, 4 or 8 mg/kg bw per day over 90 days. A 7 days per week dose schedule was applied (Karacao glu, 2016, E-mail communication, 25 October 2016).…”

Section: A Furanmentioning

confidence: 99%

Risks for public health related to the presence of furan and methylfurans in food

Knutsen¹,

Alexander²,

Barregård³

et al. 2017

EFS2

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The European Commission asked EFSA for a scientific evaluation on the risk to human health of the presence of furan and methylfurans (2-methylfuran, 3-methylfuran and 2,5-dimethylfuran) in food. They are formed in foods during thermal processing and can co-occur. Furans are produced from several precursors such as ascorbic acid, amino acids, carbohydrates, unsaturated fatty acids and carotenoids, and are found in a variety of foods including coffee and canned and jarred foods. Regarding furan occurrence, 17,056 analytical results were used in the evaluation. No occurrence data were received on methylfurans. The highest exposures to furan were estimated for infants, mainly from ready-to-eat meals. Grains and grain-based products contribute most for toddlers, other children and adolescents. In adults, elderly and very elderly, coffee is the main contributor to dietary exposure. Furan is absorbed from the gastrointestinal tract and is found in highest amounts in the liver. It has a short half-life and is metabolised by cytochrome P450 2E1 (CYP2E1) to the reactive metabolite, cis-but-2-ene-1,4-dialdehyde (BDA). BDA can bind covalently to amino acids, proteins and DNA. Furan is hepatotoxic in rats and mice with cholangiofibrosis in rats and hepatocellular adenomas/carcinomas in mice being the most prominent effects. There is limited evidence of chromosomal damage in vivo and a lack of understanding of the underlying mechanism. Clear evidence for indirect mechanisms involved in carcinogenesis include oxidative stress, gene expression alterations, epigenetic changes, inflammation and increased cell proliferation. The CONTAM Panel used a margin of exposure (MOE) approach for the risk characterisation using as a reference point a benchmark dose lower confidence limit for a benchmark response of 10% of 0.064 mg/kg body weight (bw) per day for the incidence of cholangiofibrosis in the rat. The calculated MOEs indicate a health concern. This conclusion was supported by the calculated MOEs for the neoplastic effects.

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Toxicity of food contaminant furan on liver and kidney of growing male rats

Cited by 29 publications

References 44 publications

Furan-induced cardiotoxicity in diabetic rats and protective role of lycopene

Furan-induced cardiotoxicity in diabetic rats and protective role of lycopene

Furan-induced hepatotoxic and hematologic changes in diabetic rats: the protective role of lycopene

Risks for public health related to the presence of furan and methylfurans in food

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