Toxicity of Gold Nanoparticles

Caballero-Díaz, Encarnación; Valcárcel, Miguel

doi:10.1016/b978-0-444-63285-2.00005-5

Cited by 15 publications

(7 citation statements)

References 155 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, combined cancer photothermal-chemotherapy based on gold nanoparticles has received increasing attention (Banu et al, 2015;Zhang et al, 2013). However, the potential toxicity and instability of gold nanoparticles-bearing chemotherapeutic agents cannot be belittled (Siddiqi et al, 2012;Caballero-D ıaz E & Valc arcel M, 2014). To solve the problem, we used an amphiphilic glycolipid-like chitosan-stearic acid copolymer (CSO-SA), which was synthesized by the conjugation between chitosan oligosaccharide and stearic acid that displayed a so-called special spatial structure of multiple 'minor-cores' in the aqueous medium with excellent internalization into cells and increased cellular uptake of the payload, to encapsulate HAuNS and PTX (Supplementary Figure S3).…”

Section: Discussionmentioning

confidence: 99%

Near infrared light mediated photochemotherapy for efficiently treating deep orthotopic tumors guided by ultrasound imaging

et al. 2017

View full text Add to dashboard Cite

Recently, Combined cancer photothermal-chemotherapy has become a highly promising strategy in cancer treatment for its enhanced therapeutic efficacy, controlled drug release and reduced systemic toxicity. Almost all the reported strategies based on photothermal-chemotherapy have only focused on the treatment of superficial or subcutaneous cancer, which are not considered as a more clinically relevant and better predictive models of drug efficacy than orthotopic tumor models. Here, we reported an EphB4 receptor-targeting polymeric nanoplatform containing hollow gold nanospheres (HAuNS) and the anticancer drug paclitaxel (PTX) for cancer photothermal-chemotherapy. With the modification of the TNYL peptide, HP-TCS could specifically internalize into EphB4-positive SKOV3 and CT26 cells, further inducing the selective killing of the cells in co-cultured system, namely, EphB4-positive and EphB4-negative cells. Obvious targeting of the micelles into implanted orthotopic or subcutaneous tumors with high EphB4 expression was observed. Interestingly, increased accumulation of HP-TCS was observed in orthotopic colon tumors when compared with ectopic tumors. Highly specific accumulation of HP-TCS in EphB4-positive tumors significantly increased the feasibility of photothermal-chemotherapy mediated by the near infrared reflection (NIR) laser. Then, a systemic antitumor efficiency study was performed in implanted subcutaneous and visual orthotopic tumor models. Precise NIR laser irradiation could be localized on tumors under the guidance of B-mode ultrasound imaging, causing a rapid photothermal ablation effect limited to the region of tumors. Tumor growth was significantly inhibited by the photothermal-chemotherapy due to the triggered release of PTX. Our study provided a promising strategy of NIR laser-mediated photothermal-chemotherapy based on HP-TCS against the tumors (specially, deep orthotopic tumors) with high EphB4 expression. ARTICLE HISTORY

show abstract

Section: Discussionmentioning

confidence: 99%

Near infrared light mediated photochemotherapy for efficiently treating deep orthotopic tumors guided by ultrasound imaging

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Further structural modifications like production in core-shell structures (Mohapatra et al, 2008), covering nanoparticles with polymers (Kim, Park, Lee, Jeong, & Jon, 2007), lipids, or glycoproteins (Mieszawska et al, 2012), functionalizing nanoparticles with a function group may result in increasing their stability, circulation time in vivo applications, targeting a specific organ or tissue (Zeng et al, 2011) or make the nanoparticles available to be used multimodel imaging (Sun et al, 2011). Although gold nanoparticles are often considered to be nontoxic and biocompatible (Sperling, Gil, Zhang, & Zanella, 2008;Thakor, Jokerst, Zavaleta, Massoud, & Gambhir, 2011), it has been reported that in certain particle sizes gold nanoparticles show toxic behaviors (Caballero-Díaz & Chemistry, 2014;Wang, Lu, Tovmachenko, Rai, & Yu, 2008;Yildirimer, Thanh, Loizidou, & Seifalian, 2011), where coating the nanoparticles may eliminate unwanted properties.…”

Section: Gold Nanoparticle Contrast Agentsmentioning

confidence: 99%

Evaluation of X‐ray tomography contrast agents: A review of production, protocols, and biological applications

Koç

Aslan

Kao

et al. 2019

Microscopy Res & Technique

View full text Add to dashboard Cite

X‐ray computed tomography is a strong tool that finds many applications both in medical applications and in the investigation of biological and nonbiological samples. In the clinics, X‐ray tomography is widely used for diagnostic purposes whose three‐dimensional imaging in high resolution helps physicians to obtain detailed image of investigated regions. Researchers in biological sciences and engineering use X‐ray tomography because it is a nondestructive method to assess the structure of their samples. In both medical and biological applications, visualization of soft tissues and structures requires special treatment, in which special contrast agents are used. In this detailed report, molecule‐based and nanoparticle‐based contrast agents used in biological applications to enhance the image quality were compiled and reported. Special contrast agent applications and protocols to enhance the contrast for the biological applications and works to develop nanoparticle contrast agents to enhance the contrast for targeted drug delivery and general imaging applications were also assessed and listed.

show abstract

Section: Gold Nanoparticlesmentioning

confidence: 99%

“…Gold Nanoparticles (AuNPs) are widely used in a long list of different applications, as for example photoelectrochemistry, catalysis, sensor and medical applications, including imaging, therapy, or biosensors, among others (Caballero-Díaz and Valcárcel, 2014). Considering all the ENMs, AuNPs have the least empiric evidence of adverse effects in organisms until now, although it is also true that there are very few studies on in vivo toxicity (Caballero-Díaz and Valcárcel, 2014). In vitro, some of the mechanisms reported are: Genotoxicity, generation of ROS, mitochondrial damage, apoptosis, leakage of toxic materials, endocrine disruption, interactions with lipids and proteins, altered gene expression and cellular morphology changes (Caballero-Díaz and Valcárcel, 2014).…”

Section: Gold Nanoparticlesmentioning

confidence: 99%

“…Considering all the ENMs, AuNPs have the least empiric evidence of adverse effects in organisms until now, although it is also true that there are very few studies on in vivo toxicity (Caballero-Díaz and Valcárcel, 2014). In vitro, some of the mechanisms reported are: Genotoxicity, generation of ROS, mitochondrial damage, apoptosis, leakage of toxic materials, endocrine disruption, interactions with lipids and proteins, altered gene expression and cellular morphology changes (Caballero-Díaz and Valcárcel, 2014). The greatest number of experiments establishes the low or no toxicity for zebrafish.…”

Section: Gold Nanoparticlesmentioning

confidence: 99%

See 1 more Smart Citation

Toxicology of Nanomaterials on Zebrafish

León¹,

Cotto²,

Márquez³

2019

American Journal of Engineering and Applied Sciences

View full text Add to dashboard Cite

Increases in the use and the progressive manufacture of new Engineered Nanomaterials (ENMs) lead to inquire about their impact on the environment. Due to the small size, high reactivity inside organisms and the unusual physicochemical properties of the ENMs, the predictions of toxicity are very complex. The zebrafish (Danio rerio) has been granted as a practical alternative to study the toxicity of ENMs. In this article the toxic effects of silver nanoparticles, titanium oxide nanoparticles, zinc oxide nanoparticles, carbon nanotubes, copper nanoparticles, gold nanoparticles, cadmium nanoparticles and nano plastics were reviewed trough the most recent literature available. Every ENMs should be studied in depth independently, considering co-exposures, environmental matrices, the effects of variations in size and concentrations, the potential effects of prolonged exposure, the coverage of ENMs, specific organism and targeted organs. This information will help to identify deficiencies in research trends and reinforce the safest ways to use ENMs.

show abstract

Toxicity of Gold Nanoparticles

Cited by 15 publications

References 155 publications

Near infrared light mediated photochemotherapy for efficiently treating deep orthotopic tumors guided by ultrasound imaging

Near infrared light mediated photochemotherapy for efficiently treating deep orthotopic tumors guided by ultrasound imaging

Evaluation of X‐ray tomography contrast agents: A review of production, protocols, and biological applications

Toxicology of Nanomaterials on Zebrafish

Contact Info

Product

Resources

About