Toxicity of hydroxylated alkyl-phenanthrenes to the early life stages of Japanese medaka (Oryzias latipes)

Fallahtafti, Shirin; Rantanen, Toni; Brown, R. Stephen; Snieckus, Victor; Hodson, Peter V.

doi:10.1016/j.aquatox.2011.10.007

Cited by 90 publications

(56 citation statements)

References 21 publications

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“…A trend toward oxidative inactivation with increasing exposure to dilbit was also apparent in medaka exposed to WAF. These trends indicate a possible role of ROS or PAH metabolites in the toxic effects of oil on embryos, consistent with the apparently greater toxicity of metabolites than the parent PAHs (Carney et al, 2008;Fallahtafti et al, 2012;Scott and Hodson, 2008). Differences in antioxidant responses between WAF-and CEWAF-treated fish could very well be attributed to the additional disruptive effects of Corexit ® known to affect phospholipid membranes of aquatic organisms (Singer et al, 1995a,b), to alter intracellular redox balance, and to inhibit mitochondrial function in mammals (Zheng et al, 2014).…”

Section: Discussionsupporting

confidence: 60%

“…The malformations evident as BSD in embryonic and juvenile fish exposed to oil have been attributed largely to the toxic effects of 3-to 5-ringed PAH, including alkyl-phenanthrenes (Adams et al, 2014b;Incardona et al, 2006Incardona et al, , 2011aFallahtafti et al, 2012;Turcotte et al, 2011), although the myriad of compounds comprising dilbit may include unknown constituents that contributed to embryotoxicity. Here, we present the first report of similar malformations in Japanese medaka hatchlings exposed to dilbit.…”

Section: Discussionmentioning

confidence: 98%

“…Toxicity testing followed the methods outlined by Turcotte et al (2011) andFallahtafti et al (2012). Each replicate contained duplicate jars of 10 embryos per treatment (n = 40 per treatment).…”

Section: Chronic Toxicity Testsmentioning

confidence: 99%

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Diluted bitumen causes deformities and molecular responses indicative of oxidative stress in Japanese medaka embryos

2015

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 98%

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Diluted bitumen causes deformities and molecular responses indicative of oxidative stress in Japanese medaka embryos

2015

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“…This difference in development time means that medaka have an exposure duration which is longer than zebrafish. Zebrafish and Japanese medaka have shown reliable results in toxicity assessment using aqueous exposure (Fallahtafti et al 2012;Fang et al 2013;Hawliczek et al 2012;Huang et al 2012;Incardona et al 2011). In the case of hydrophobic compounds, direct waterborne exposure is not suitable and therefore alternative tests had to be developed.…”

Section: Introductionmentioning

confidence: 99%

Influence of sediment composition on PAH toxicity using zebrafish (Danio rerio) and Japanese medaka (Oryzias latipes) embryo-larval assays

Perrichon

Bihanic

Bustamante

et al. 2014

Environ Sci Pollut Res

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Due to hydrophobic and persistent properties, polycyclic aromatic hydrocarbons (PAHs) have a high capacity to accumulate in sediment. Sediment quality criteria, for the assessment of habitat quality and risk for aquatic life, include understanding the fate and effects of PAHs. In the context of European regulation (REACH and Water Framework Directive), the first objective was to assess the influence of sediment composition on the toxicity of two model PAHs, benzo[a]pyrene and fluoranthene using 10-day zebrafish embryo-larval assay. This procedure was undertaken with an artificial sediment in order to limit natural sediment variability. A suitable sediment composition might be then validated for zebrafish and proposed in a new OECD guideline for chemicals testing. Second, a comparative study of toxicity responses from this exposure protocol was then performed using another OECD species, the Japanese medaka. The potential toxicity of both PAHs was assessed through lethal (e.g., survival, hatching success) and sublethal endpoints (e.g., abnormalities, PMR, and EROD) measured at different developmental stages, adapted to the embryonic development time of both species. Regarding effects observed for both species, a suitable artificial sediment composition for PAH toxicity testing was set at 92.5 % dry weight (dw) silica of 0.2-0.5-mm grain size, 5 % dw kaolin clay without organic matter for zebrafish, and 2.5 % dw blond peat in more only for Japanese medaka. PAH bioavailability and toxicity were highly dependent on the fraction of organic matter in sediment and of the K ow coefficients of the tested compounds. The biological responses observed were also dependent of the species under consideration. Japanese medaka embryos appeared more robust than zebrafish embryos for understanding the toxicity of PAHs following a sediment contact test, due to the longer exposure duration and lower sensitivity of sediment physical properties.

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“…Herein, we demonstrate that DAPCI coupled with a portable mass spectrometer is a suitable analytical method that can be used for "near-instant" in situ detection of polar alkylated benzenes and non-polar PAHs that are difficult to analyze [44]. In this work, we investigate the use of DAPCI for the detection of 1,2,3,5-tetramethylbenzene, pentamethylbenzene, h e x a m e t h y l b e n z e n e , f l u o r a n t h e n e , a n t h r a c e n e , benzo[k]fluoranthene, dibenz[a,h]anthracene, acenaphthene, indeno [1,2,3-c,d]pyrene, 9-ethylfluorene, and 1-benzyl-3-methyl-naphthalene.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Polycyclic Aromatic Hydrocarbons Using Desorption Atmospheric Pressure Chemical Ionization Coupled to a Portable Mass Spectrometer

Jjunju

Maher

et al. 2014

J. Am. Soc. Mass Spectrom.

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Abstract. Desorption atmospheric pressure chemical ionization (DAPCI) is implemented on a portable mass spectrometer and applied to the direct detection of polycyclic aromatic hydrocarbons (PAHs) and alkyl substituted benzenes. The presence of these compounds in the environment poses a significant threat to the health of both humans and wildlife because of their carcinogenic, toxic, and mutagenic properties. As such, instant detection outside of the laboratory is of particular importance to allow in-situ measurement at the source. Using a rapid, high throughput, miniature, handheld mass spectrometer, several alkyl substituted benzenes and PAHs (i.e., 1,2,3,5-tetramethylbenzene, pentamethylbenzene, hexamethylbenzene, fluoranthene, anthracene, benzo[k]fluoranthene, dibenz [a,h]anthracene, acenaphthene, indeno [1,2,3-c,d]pyrene, 9-ethylfluorene, and 1-benzyl-3-methyl-naphthalene) were identified and characterized using tandem mass spectrometry (MS/MS) from ambient surfaces, in the open air. This method can provide almost instantaneous information while minimizing sample preparation, which is advantageous in terms of both cost and simplicity of analysis. This MS-based technique is applicable to a wide range of environmental organic molecules.

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Toxicity of hydroxylated alkyl-phenanthrenes to the early life stages of Japanese medaka (Oryzias latipes)

Cited by 90 publications

References 21 publications

Diluted bitumen causes deformities and molecular responses indicative of oxidative stress in Japanese medaka embryos

Diluted bitumen causes deformities and molecular responses indicative of oxidative stress in Japanese medaka embryos

Influence of sediment composition on PAH toxicity using zebrafish (Danio rerio) and Japanese medaka (Oryzias latipes) embryo-larval assays

Analysis of Polycyclic Aromatic Hydrocarbons Using Desorption Atmospheric Pressure Chemical Ionization Coupled to a Portable Mass Spectrometer

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