Toxicity of methylsulfonylmethane in rats

The Anti-inflammatory Effects of Methylsulfonylmethane on Lipopolysaccharide-Induced Inflammatory Responses in Murine Macrophages

“…19,20) There is limited formal safety data, and no long-term assessment has been performed. However, MSM is rapidly excreted from the body, 32,33) and animal toxicity studies of MSM have shown only minor adverse effects with doses of 1.5 g/kg and 2.0 g/kg of MSM for 90 d. 34) This represents a human dose of 30-42 g/d, which is equivalent to 5-7 times the proposed maximum recommended human dose of 6 g/d. 34) Another study confirmed that MSM has no toxic effects on either pregnant rats or their fetuses.…”

“…However, MSM is rapidly excreted from the body, 32,33) and animal toxicity studies of MSM have shown only minor adverse effects with doses of 1.5 g/kg and 2.0 g/kg of MSM for 90 d. 34) This represents a human dose of 30-42 g/d, which is equivalent to 5-7 times the proposed maximum recommended human dose of 6 g/d. 34) Another study confirmed that MSM has no toxic effects on either pregnant rats or their fetuses. 35) Based on these previous results and the present data, we believe MSM is relatively safe and effective for the treatment of inflammatory diseases.…”

Assessment of methylsulfonylmethane as a permeability enhancer for regional EDTA chelation therapy

“…The organosulfone compound has been used as a polar solvent for both organic and inorganic substances, an intermediate for synthesis of drugs and a dietary supplement. MSM, which is found widely in fruits, vegetables, and grains in small amount, is considered safe at recommended oral dosages for humans (Horváth et al, 2002). This study showed that MSM enhanced the transport of an indicator dye, methylene blue, and the transport of a commonly used antibiotic, ciprofloxacin, across a membrane.…”

GC/MS analysis and In-vitro Antioxidant activity of methanol extract of Ulothrix flacca and its main constituent Dimethyl Sulfone.

“…Dimethyl sulfone has also been detected in the human brain [20], blood plasma, and cerebrospinal fluid [21] by proton magnetic resonance spectroscopy. Dimethyl sulfone is volatile, easily lost during cooking, and is believed to be non-toxic [22], [23]. Dimethyl sulfone decreases arthritis pain and improves physical function of osteoarthritis human knees without major adverse events [24].…”