Toxicity of nickel and cobalt in Japanese flounder

Sun, Zhizhong; Gong, Chengliang; Ren, Jiangong; Zhang, Xiaoyan; Wang, Guixing; Liu, Yufeng; Ren, Yuqin; Zhao, Yaxian; Yu, Qin; Wang, Yufen; Hou, Jilun

doi:10.1016/j.envpol.2020.114516

Cited by 38 publications

(23 citation statements)

References 60 publications

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“…In fish, it potentially was responsible for the lethality of zebrafish VitE-deficient embryos [ 56 ]. It might be activated by low temperature (Nile tilapia), hypoxia (Silver sillago) stress and heavy metal (Japanese flounder) [ 57 – 59 ], and could be induced by Escherichia coli and then led to the red blood cells (RBCs) death of grass carp [ 60 ]. It could be checked at the gene expression level and characterized by the morphology of mitochondria [ 32 , 35 , 36 , 38 , 39 , 41 – 45 , 61 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative transcriptomic analysis reveals an association of gibel carp fatty liver with ferroptosis pathway

Zhang

Zhou

et al. 2021

BMC Genomics

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Background Fatty liver has become a main problem that causes huge economic losses in many aquaculture modes. It is a common physiological or pathological phenomenon in aquaculture, but the causes and occurring mechanism are remaining enigmatic. Methods Each three liver samples from the control group of allogynogenetic gibel carp with normal liver and the overfeeding group with fatty liver were collected randomly for the detailed comparison of histological structure, lipid accumulation, transcriptomic profile, latent pathway identification analysis (LPIA), marker gene expression, and hepatocyte mitochondria analyses. Results Compared to normal liver, larger hepatocytes and more lipid accumulation were observed in fatty liver. Transcriptomic analysis between fatty liver and normal liver showed a totally different transcriptional trajectory. GO terms and KEGG pathways analyses revealed several enriched pathways in fatty liver, such as lipid biosynthesis, degradation accumulation, peroxidation, or metabolism and redox balance activities. LPIA identified an activated ferroptosis pathway in the fatty liver. qPCR analysis confirmed that gpx4, a negative regulator of ferroptosis, was significantly downregulated while the other three positively regulated marker genes, such as acsl4, tfr1 and gcl, were upregulated in fatty liver. Moreover, the hepatocytes of fatty liver had more condensed mitochondria and some of their outer membranes were almost ruptured. Conclusions We reveal an association between ferroptosis and fish fatty liver for the first time, suggesting that ferroptosis might be activated in liver fatty. Therefore, the current study provides a clue for future studies on fish fatty liver problems.

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Section: Discussionmentioning

confidence: 99%

Comparative transcriptomic analysis reveals an association of gibel carp fatty liver with ferroptosis pathway

Zhang

Zhou

et al. 2021

BMC Genomics

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“…The occurrence of intracellular death and the different mechanisms of the same fish virus strain in different host cells have not been investigated, and more reports from this field are needed because they may provide a theoretical basis for clarifying the pathogenic mechanism of these viruses for developing corresponding prevention and control technologies. Foreign chemicals such as heavy metals cannot be metabolized in fish after they are ingested, and they can accumulate in the kidneys, livers and other organs of the fish even after low-concentration exposure (Zhang et al 2019;Sun et al 2020b). A high concentration of heavy metals induces toxic effects, which have impacts on the growth and development of fish and may even lead to the death of exposed fish.…”

Section: Discussionmentioning

confidence: 99%

“…2019; Sun et al . 2020b). A high concentration of heavy metals induces toxic effects, which have impacts on the growth and development of fish and may even lead to the death of exposed fish.…”

Section: Discussionmentioning

confidence: 99%

“…2019; Sun et al . 2020b). There have been sporadic reports of LRCD caused by environmental pollution (Sun et al .…”

Section: Discussionmentioning

confidence: 99%

“…A study on the chronic and acute toxicity of cobalt and nickel in Japanese flounder showed that ferroptosis‐related pathways, including unsaturated fatty acid biosynthesis, fatty acid extension and metabolism, steroid biosynthesis and PPAR signalling, were all significantly enriched, indicating that cobalt and nickel exposure increases lipid peroxide in Japanese flounder and leads to ferroptosis (Sun et al . 2020b). Similar phenomena were observed under low‐temperature stress.…”

Section: Ferroptosismentioning

confidence: 99%

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Lytic regulated cell death in aquaculture fish

Xia

Zhang

et al. 2021

Reviews in Aquaculture

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Cell death is an important physiological and pathological phenomenon in multicellular animals and occurs widely in various body's systems. In recent years, researchers have gained a deeper understanding of the mechanisms of necrosis and apoptosis in mammals. In addition, many new forms of lytic regulated cell death (RCD), such as pyroptosis, necroptosis and ferroptosis, have been discovered, thus enhancing our understanding of the molecular mechanisms of programmed cell death (PCD) and the associated signalling pathways as well as their relationship with diseases. However, our understanding of lytic RCD in fish is limited. Recently, some progress has been made regarding the induction conditions, expression of related genes and regulation of lytic RCD in fish. Furthermore, research on the roles of lytic RCD in tissue development, against pathogenic microorganism, inflammatory disease and neurological disease, has also been advanced. Understanding lytic RCD in fish will enable the regulation of its occurrence through human intervention to inhibit disease processes, improve fish health and explore possible countermeasures based on these basic theoretical studies.

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