Toxicity of Ozone

Mittler, Sidney; King, Maurice E.; Burkhardt, Betty

doi:10.1021/ba-1959-0021.ch046

Cited by 14 publications

(5 citation statements)

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“…thick) and linen were also in the intermediate range and showed a decrease with long term exposure to O3. Aluminum and plate glass indicated relatively low values of rate constants, and that for aluminum is in qualitative agreement with the statement by Mittler et al (1959); their toxicity test chamber was "lined with aluminum sheet to prevent undue decomposition of ozone ....'' Plywood Ok in. thick) led to an intermediate decomposition rate and the application of varnish did not produce a significant change.…”

Section: Characterization Of Test Chambersupporting

confidence: 81%

Concentrations, decay rates, and removal of ozone and their relation to establishing clean indoor air

Sabersky¹,

Sinema²,

Shair³

1973

Environ. Sci. Technol.

148

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Section: Characterization Of Test Chambersupporting

confidence: 81%

Concentrations, decay rates, and removal of ozone and their relation to establishing clean indoor air

Sabersky¹,

Sinema²,

Shair³

1973

Environ. Sci. Technol.

148

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“…361/2007 determining conditions of occupational health protection [33]; the permissible exposure limit is 0.1 mg/m 3 (8-h mean), the highest permissible concentration being 0.2 mg/m 3 (mean concentration of the substance measured for up to 15 min). Ozone limits were also set for various animal species-in cats, Mittler et al [34] reported that the LC50 value in a 3-h exposure to ozone is 34.5 ppm. The manufacturers of the generators used in this study warn of possible negative effects to human and animal health; during the application, neither animals nor persons should be present in the treated area, and, after treatment, it is recommended to ensure thorough ventilation for 30 to 60 min.…”

Section: Discussionmentioning

confidence: 99%

Impact of the Application of Gaseous Ozone on Selected Pathogens Found in Animal Shelters and Other Facilities

Vojtkovská,

Lobová,

Voslářová

et al. 2023

Animals

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Correctly selecting disinfection procedures is crucial in facilities housing a high number of animals as it directly affects their health. The aim of this study was to verify the virucidal effect of gaseous ozone delivered by commercially available generators under controlled experimental conditions on a selection of viral pathogens (feline coronavirus, canine coronavirus, feline calicivirus, feline parvovirus) commonly found in shelters and other facilities. Two ozone generators with outputs of 3.5 g/h and 20 g/h were used to produce ozone. Virus viability after the application of ozone was evaluated by examining for typical pathogen-specific cytopathic effects on the CRFK (Crandell–Rees Feline Kidney) cell line post-incubation. No cytopathic effect was observed in feline coronavirus after the 2-h application of ozone; in canine coronavirus, the absence of a cytopathic effect was observed after the 4-h application of ozone. The absence of a cytopathic effect in feline calicivirus was observed after the 6-h application of ozone; the viability of feline parvovirus was not impaired even by the 6-h application of ozone. The results of the study confirm lower resistance to the application of gaseous ozone in enveloped viruses.

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“…However, the 4-6% lower body weight in the 1.0-ppm exposure group and the nearly 100% incidence of pulmonary and nasal lesions suggests that a maximum concentration was reached in these studies. Generally, acute ozone exposure is more life-threatening than subsequent exposures because some adaptation occurs with continued exposure (29,35). Ozone concentrations of 2.0-4.0 ppm are acutely lethal to rodents (29) or cause significant pulmonary edema (18), suggesting that concentrations higher than 1.0 ppm might not have been tolerated.…”

Section: Nonneoplastic Lesionsmentioning

confidence: 99%

“…Generally, acute ozone exposure is more life-threatening than subsequent exposures because some adaptation occurs with continued exposure (29,35). Ozone concentrations of 2.0-4.0 ppm are acutely lethal to rodents (29) or cause significant pulmonary edema (18), suggesting that concentrations higher than 1.0 ppm might not have been tolerated. Because of the late-occurring pulmonary tumors in diesel exhaust studies (27), we also included lifetime studies.…”

Section: Nonneoplastic Lesionsmentioning

confidence: 99%

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Toxicology and Carcinogenesis Studies of Ozone and Ozone 4-(N-Nitrosomethylamino)-1-(3-Pyridyl)-1-Butanone in Fischer-344/N Rats

et al. 1994

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The purpose of this study was to evaluate the toxicity and potential carcinogenicity or cocarcinogenicity of ozone exposure in rats. Fischer-344/N (F-344/N) rats were exposed 6 hr/day, 5 days/wk, to 0, 0.12, 0.5, or 1.0 ppm ozone by inhalation for 2-yr and lifetime exposures. The cocarcinogenicity study included subcutaneous administration of 0, 0.1, or 1.0 mg/kg body weight of 4-( N -nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) and inhalation of 0 or 0.5 ppm ozone to male rats. NNK was administered by subcutaneous injections 3 times per week for the first 20 wk with ozone inhalation exposure. The ozone inhalation exposure was for 2 yr (104 wk), including the first 20 wk of NNK treatment and continuing for 84 wk after the last NNK injection. Ozone exposure caused a concentration-related increase in inflammation of the centriacinar region of the lung. There was also increased fibrosis and an extension of the bronchiolar epithelium in these centriacinar regions to involve the proximal alveoli. There was no increased incidence of neoplasms at any site, including the lung, that was associated with ozone exposure. Rats administered 1.0 mg/kg body weight NNK alone had an increased incidence of bronchiolar/alveolar neoplasms, but this effect was not enhanced by ozone exposure. Ozone exposure for 2 yr and lifetime was associated with site-specific toxic alterations in the nasal passage and lung similar to those previously described for short-term exposures.While there was significant attenuation of the pulmonary lesions as compared to short-term exposures, lesions persisted in the lifetime study and there was evidence of a mild progressive fibrosis. We conclude that under the conditions of these studies: (a) ozone exposure is not carcinogenic to either male or female F-344/N rats, (b) ozone does not enhance the incidence of pulmonary neoplasms in F-344/N rats exposed to a known pulmonary carcinogen (NNK), and (c) mild site-specific toxic lesions characteristic of ozone exposure persist in the nasal passage and lung throughout the lifetime of the rat with continued ozone exposure.

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Toxicity of Ozone

Cited by 14 publications

References 0 publications

Concentrations, decay rates, and removal of ozone and their relation to establishing clean indoor air

Concentrations, decay rates, and removal of ozone and their relation to establishing clean indoor air

Impact of the Application of Gaseous Ozone on Selected Pathogens Found in Animal Shelters and Other Facilities

Toxicology and Carcinogenesis Studies of Ozone and Ozone 4-(N-Nitrosomethylamino)-1-(3-Pyridyl)-1-Butanone in Fischer-344/N Rats

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