Toxicity of Penicillium citrinum AUA-532 Contaminated Corn and Citrinin in Broiler Chicks

Roberts, Winford T.; Mora, E. C.

doi:10.3382/ps.0571221

Cited by 29 publications

(20 citation statements)

References 22 publications

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“…The enlargement in size and the increase in the relative weight of the liver in CIT treatment might be due to hepatic degeneration and sinusoidal congestion. These findings were in accordance with the earlier reports in poultry (Ames et al, 1976;Roberts and Mora, 1978;Uma and Vikram Reddy, 1995). Similarly, hepatic enlargement in endosulfan treatment might be attributed to degenerative changes including karyomegaly, hepatocytomegaly and congestion of central and portal veins.…”

Section: Discussionsupporting

confidence: 83%

Citrinin and endosulfan induced maternal toxicity in pregnant Wistar rats: pathomorphological study

Singh

Sharma

Dwivedi

et al. 2007

J of Applied Toxicology

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Dietary exposures to environmental food pollutants such as mycotoxin(s) or pesticide(s) have gained immense significance due to their adverse effects on production and reproduction in animal and human populations. The present investigation was conducted to evaluate the maternal toxicity of citrinin (CIT) and endosulfan administered per os either alone or in combination in pregnant rats during gestational days 6-20. CIT (group I, 10 mg kg(-1) feed, through diet) and endosulfan (group II, 1 mg kg(-1) body weight, by oral intubation) when administered either alone or in combination (group III) in Wistar rats caused clinical signs of toxicity and pathomorphological changes in all the toxin treated groups, the severity being more pronounced in the combination treatment compared with that observed in the control (group IV). The rate of fetal resorptions was highest (22.22%) in the combination treatment followed by endosulfan (16.48%) and CIT (12.50%) treatment groups compared with the control group (3.86%). The histopathological changes such as engorged vasculature, vacuolar degeneration and karyomegaly in liver; congestion, tubular degeneration and cast formation in kidneys; vascular changes and hemosiderosis in uterus and lymphocytic depletion and apoptosis in the lymphoid organs were recorded in the animals of the toxin treated groups. The lesions were consistent and more severe in the combination treatment group compared with the individual treatment groups, suggesting an additive interaction of CIT and endosulfan in inducing maternal toxicity in Wistar rats.

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Section: Discussionsupporting

confidence: 83%

Citrinin and endosulfan induced maternal toxicity in pregnant Wistar rats: pathomorphological study

Singh

Sharma

Dwivedi

et al. 2007

J of Applied Toxicology

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“…The clinical and necropsy findings in chicks fed the 6.2% P. citrinum contaminated ration were identical to those symptoms previously reported (Roberts, 1977 a,b;Roberts and Mora, 1977 a,b;Roberts and Mora, 1978) in White Leghorn chicks fed a lot of 62% P. citrinum contaminated corn molded 6 months earlier.…”

Section: Resultssupporting

confidence: 83%

“…No citrinin was confirmed using the chloroform extraction method of Carlton et al (1974) or an acidified chloroform procedure (Wilson et al, 1976). An unidentified yellow-green fluorescent compound was observed (Roberts and Mora, 1977 a,b;Roberts and Mora, 1978;Roberts, 1977b).…”

Section: Resultsmentioning

confidence: 94%

“…Two replicates of 10 day-old male and female Single Comb White Leghorn (Auburn) chicks were used in each treatment. A previously described ration (Roberts and Mora, 1978) was used to prepare the control ration. Moldy corn rations were FIG.…”

Section: Preparation Of P Citrinummentioning

confidence: 99%

“…Forgacs et al (1962) were able to produce the toxicosis in chicks both in batteries and in the field using fungi isolated from feed and litter from hemorrhagic syndrome enzootic areas. Rubratoxin (Wyatt and Hamilton, 1972), aflatoxin B^ (Hamilton et al, 1971), ochratoxin A (Huff et al, 1978), T-2 toxin (Wyatt et al, 1973), and citrinin (Witlock et al, 1977;Roberts and Mora, 1977b;Roberts and Mora, 1978;Roberts, 1977b) are the major toxins associated with five fungi reported to cause the hemorrhagic anemia syndrome, yet none of these toxins caused the symptoms of the syndrome. Recent work indicated that Penicillium citrinum AUA-532 contaminated corn caused an anemia and leucopenia in chicks (Roberts, 1977b) which corresponded to the symptoms observed in the poultry hemorrhagic syndrome and confirmed the findings of Forgacs et al (1962).…”

Section: Introductionmentioning

confidence: 96%

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Hemorrhagic Syndrome of Chicks Produced by Penicillium citrinum AUA-532 Contaminated Corn

Roberts

Mora

1979

Poultry Science

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Rations containing 0%, 6.2%, and 62% Penicillium citrinum contaminated corn were fed to White Leghorn chicks for 5 weeks. The 62% ration induced hemorrhaging throughout the digestive tract which resembled the lesions observed in acute cases of the poultry hemorrhagic syndrome. The 6.2% ration caused atrophy of lymphoid tissue, anemia, leucopenia, and fatty bone marrow which resembled the lesions observed in chronic cases of the poultry hemorrhagic syndrome. The syndrome was reproduced in chicks using ethanol and chloroform extracts of the P. citrinum contaminated corn.

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Citrinin

Ajithkumar,

Savitha,

Renuka

et al. 2023

Anti‐Mycotoxin Strategies for Food and Feed

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Toxicity of Penicillium citrinum AUA-532 Contaminated Corn and Citrinin in Broiler Chicks

Cited by 29 publications

References 22 publications

Citrinin and endosulfan induced maternal toxicity in pregnant Wistar rats: pathomorphological study

Citrinin and endosulfan induced maternal toxicity in pregnant Wistar rats: pathomorphological study

Hemorrhagic Syndrome of Chicks Produced by Penicillium citrinum AUA-532 Contaminated Corn

Citrinin

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